Abstract:
BACKGROUND:Idiopathic Parkinson's disease (IPD) has a long preclinical phase. RESEARCH QUESTION:This study assesses data on prediagnostic markers of IPD from a longitudinal, natural history study of aging. METHODS:Participants were selected from the database of the Baltimore Longitudinal Study of Aging, and included 10 prediagnosed IPD cases (eight men and two women) and 30 age and sex matched healthy controls. Patients with prediagnosed IPD had already had an assessment for IPD 2.6 ± 1.3 years (range 1.0-5.3 years) before the actual diagnosis, including: gait speed (six-meter corridor walk), spatio-temporal gait parameters using Vicon motion capture, balance, upper-limb motor skills, neuropsychological profile, and non-motor symptoms. RESULTS:Prediagnosed IPD cases compared to controls had slower gait speed (Δ=-0.13 m.s-1, p = 0.03) due to shorter step length (Δ=-5 cm, p = 0.004), worse visuospatial ability (card rotation test, Δ=-42, p = 0.0001) and worse executive function (category fluency test, Δ=-2.6, p = 0.04). SIGNIFICANCE:Our findings identify dimensions that merit further study as prediagnostic markers of Idiopathic Parkinson's disease to identify patients who might benefit from future neuroprotective therapy in order to delay, or prevent, clinical manifestations.
journal_name
Gait Posturejournal_title
Gait & postureauthors
Chastan N,Bair WN,Resnick SM,Studenski SA,Decker LMdoi
10.1016/j.gaitpost.2018.12.039subject
Has Abstractpub_date
2019-02-01 00:00:00pages
500-505eissn
0966-6362issn
1879-2219pii
S0966-6362(18)30438-7journal_volume
68pub_type
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