Abstract:
BACKGROUND:Heart failure (HF) is a well-recognized public health concern and imposes high economic and societal costs. Decision analytic models exist for evaluating the economic ramifications associated with HF. Despite this, studies that appraise these modelling approaches for augmenting best-practice decisions remain scarce. OBJECTIVE:Our objective was to conduct a systematic literature review (SLR) of published economic models for the management of HF and describe their general and methodological features. METHODS:This SLR employed a combination of relevant search terms associated with HF, which were used in a number of databases, including MEDLINE, Embase, the National Health Service Economic Evaluation Database, Cost-Effectiveness Analysis Registry, ScHARR Health Utilities Database and Cochrane Library Database. A number of model features (i.e. model structure, specification, outcomes assessed, scenario and sensitivity analysis, key model drivers) were extracted and subsequently summarized. RESULTS:Of 64 publications retained, a selection of modelling approaches were identified, including Markov (n = 28), trial-based analytic (n = 22), discrete-event simulation (n = 6), survival analytic (n = 7) and decision-tree modelling (n = 1) approaches. The bulk of publications employed either a cost-utility (n = 27) or cost-effectiveness (n = 36) analysis and evaluated more than one study outcome, which typically included overall costs (n = 59), incremental cost-effectiveness ratios (n = 55), life-years gained (n = 48) and willingness-to-pay thresholds (n = 37). Most publications focused on patients with chronic HF (n = 40) and used New York Heart Association (NYHA) disease classifications to categorize patients and determine disease severity. Few (n = 19) publications documented the use of hospitalization states for modelling patient outcomes and associated costs. A quality assessment of the included publications revealed most articles demonstrated reasonable methodological value. CONCLUSIONS:We identified numerous decision analytic modelling approaches for evaluating the cost effectiveness of pharmacologic treatments in HF. A Markov cohort model approach was most commonly used, and most models relied on NYHA classes as a proxy of HF severity, disease progression and prognosis.
journal_name
Pharmacoeconomicsjournal_title
PharmacoEconomicsauthors
Di Tanna GL,Bychenkova A,O'Neill F,Wirtz HS,Miller P,Ó Hartaigh B,Globe Gdoi
10.1007/s40273-018-0755-xsubject
Has Abstractpub_date
2019-03-01 00:00:00pages
359-389issue
3eissn
1170-7690issn
1179-2027pii
10.1007/s40273-018-0755-xjournal_volume
37pub_type
杂志文章abstract:BACKGROUND:Low-dose aspirin (ASA) is effective for secondary prevention of ischemic stroke but can increase the risks of hemorrhagic stroke, upper gastrointestinal bleeding (UGIB), and dyspepsia. Prophylactic administration of proton pump inhibitors (PPIs) reduces the risks of these digestive symptoms. We investigated ...
journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.1007/s40273-015-0289-4
更新日期:2015-10-01 00:00:00
abstract::This study evaluated the cost utility of adding interferon-alpha 2b to conventional treatment in patients with multiple myeloma. It also provides a methodology for transforming complex quality-of-life profiles into a single index value on the conventional 0 to 1 quality-adjusted life-year scale (QALY). From 1990 to 19...
journal_title:PharmacoEconomics
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:PharmacoEconomics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-06-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.1007/s40273-013-0072-3
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journal_title:PharmacoEconomics
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doi:10.2165/00019053-200321001-00001
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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doi:10.2165/00019053-200725070-00006
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journal_title:PharmacoEconomics
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doi:10.1007/s40273-015-0305-8
更新日期:2015-11-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.2165/00019053-200826070-00006
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journal_title:PharmacoEconomics
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
abstract::It has become increasingly popular to carry out cost-effectiveness analyses in economic evaluations of healthcare programmes. Cost-effectiveness analysis is based on the maximisation of the health effects for a given amount of resources. However, many published studies fail to report the results of cost-effectiveness ...
journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.2165/00019053-199609020-00003
更新日期:1996-02-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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journal_title:PharmacoEconomics
pub_type: 杂志文章
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.2165/00019053-199406020-00007
更新日期:1994-08-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:PharmacoEconomics
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更新日期:2000-02-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.1007/BF03262331
更新日期:2003-01-01 00:00:00
abstract::To review and critically evaluate published cost-utility analyses (CUAs) pertaining to pharmaceuticals for the past 3 decades. We examined data from the Tufts Medical Center Cost-Effectiveness Analysis Registry (www.cearegistry.org), which contains detailed information on English-language CUAs and their ratios (in $US...
journal_title:PharmacoEconomics
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更新日期:2009-01-01 00:00:00
abstract::Peptic ulcer disease (PUD) is a common medical problem costing billions of dollars annually around the world. Since the availability of the first histamine H2-receptor antagonist, cimetidine, many economic analyses have been conducted to compare the impact of this drug class on resource consumption. H2-Antagonists h...
journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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更新日期:1994-04-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
doi:10.2165/00019053-199915050-00001
更新日期:1999-05-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.1007/s40273-014-0132-3
更新日期:2014-04-01 00:00:00
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更新日期:2015-01-01 00:00:00