Abstract:
CONTEXT:This study assesses if, and how, existing methods for economic evaluation are applicable to the evaluation of personalized medicine (PM) and, if not, where extension to methods may be required. METHODS:A structured workshop was held with a predefined group of experts (n = 47), and was run using a modified nominal group technique. Workshop findings were recorded using extensive note taking, and summarized using thematic data analysis. The workshop was complemented by structured literature searches. RESULTS:The key finding emerging from the workshop, using an economic perspective, was that two distinct, but linked, interpretations of the concept of PM exist (personalization by 'physiology' or 'preferences'). These interpretations involve specific challenges for the design and conduct of economic evaluations. Existing evaluative (extra-welfarist) frameworks were generally considered appropriate for evaluating PM. When 'personalization' is viewed as using physiological biomarkers, challenges include representing complex care pathways; representing spillover effects; meeting data requirements such as evidence on heterogeneity; and choosing appropriate time horizons for the value of further research in uncertainty analysis. When viewed as tailoring medicine to patient preferences, further work is needed regarding revealed preferences, e.g. treatment (non)adherence; stated preferences, e.g. risk interpretation and attitude; consideration of heterogeneity in preferences; and the appropriate framework (welfarism vs. extra-welfarism) to incorporate non-health benefits. CONCLUSIONS:Ideally, economic evaluations should take account of both interpretations of PM and consider physiology and preferences. It is important for decision makers to be cognizant of the issues involved with the economic evaluation of PM to appropriately interpret the evidence and target future research funding.
journal_name
Pharmacoeconomicsjournal_title
PharmacoEconomicsauthors
Rogowski W,Payne K,Schnell-Inderst P,Manca A,Rochau U,Jahn B,Alagoz O,Leidl R,Siebert Udoi
10.1007/s40273-014-0211-5subject
Has Abstractpub_date
2015-01-01 00:00:00pages
49-59issue
1eissn
1170-7690issn
1179-2027journal_volume
33pub_type
杂志文章abstract:BACKGROUND AND AIM:Buprenorphine offers an alternative to methadone in the treatment of heroin dependence, and has the advantage of allowing alternate-day dosing. This study is the first to examine the cost effectiveness of buprenorphine as maintenance treatment for heroin dependence in a primary care setting using eco...
journal_title:PharmacoEconomics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Coronary heart disease (CHD) is a public health priority in the UK. The National Service Framework (NSF) has set standards for the prevention, diagnosis and treatment of CHD, which include the use of cholesterol-lowering agents aimed at achieving targets of blood total cholesterol (TC) < 5.0 mmol/L and low d...
journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.2165/00019053-200321001-00001
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00019053-200220080-00005
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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journal_title:PharmacoEconomics
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doi:10.2165/00019053-200018010-00001
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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journal_title:PharmacoEconomics
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更新日期:2012-03-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.2165/00019053-199813020-00007
更新日期:1998-02-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
doi:10.2165/00019053-199507040-00005
更新日期:1995-04-01 00:00:00
abstract:INTRODUCTION:Recent clinical trial results have demonstrated that, in patients with type 2 diabetes, second-line treatment of rosiglitazone in combination with metformin can lead to significant improvements in the control of fasting plasma glucose/ glycosylated haemoglobin A1c (HbA1c) after the failure of metformin mon...
journal_title:PharmacoEconomics
pub_type: 杂志文章,评审
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journal_title:PharmacoEconomics
pub_type: 杂志文章
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journal_title:PharmacoEconomics
pub_type: 杂志文章
doi:10.2165/00019053-199610040-00007
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pub_type: 杂志文章
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journal_title:PharmacoEconomics
pub_type: 杂志文章
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doi:10.1007/s40273-018-0670-1
更新日期:2018-09-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00019053-199915060-00005
更新日期:1999-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章,meta分析
doi:10.2165/00019053-199405060-00005
更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s40273-017-0553-x
更新日期:2017-11-01 00:00:00
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journal_title:PharmacoEconomics
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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更新日期:2017-05-01 00:00:00