Characterization of polyethylene wear particle: The impact of methodology.


:Due to the prevalence of problems caused by wear particles, the reduced durability of total joint replacements is well documented. The characterization of wear debris enables the size and morphology of these wear particles to be measured and provides an assessment of the biological response in vivo. However, the impact of different methodologies of particle analysis is not yet clear. Hence, the aim of this investigation was to analyze the influence of different particle characterization methods performed by three research centers within the scope of a "round robin test". To obtain knowledge about possible pitfalls, single steps of the particle characterization process (storage, pore size of the filter, coating durations by gold sputtering and scanning electron microscopy (SEM) magnification) were analyzed. The round robin test showed significant differences between the research groups, especially for the morphology of the particles. The SEM magnification was identified as having the greatest influence on the size and shape of the particles, followed by the storage conditions of the wear particle containing lubricant. Gold sputter coating and filter pore size also exhibit significant effects. However, even though they are statistically significant, it should be emphasized that the differences are small. In conclusion, particle characterization is a complex analytical method with a multiplicity of influencing factors. It becomes apparent that a comparison of wear particle results between different research groups is challenging.


Acta Biomater


Acta biomaterialia


Schröder C,Reinders J,Zietz C,Utzschneider S,Bader R,Kretzer JP




Has Abstract


2013-12-01 00:00:00














  • Synthesis of intracellular reduction-sensitive amphiphilic polyethyleneimine and poly(ε-caprolactone) graft copolymer for on-demand release of doxorubicin and p53 plasmid DNA.

    abstract:UNLABELLED:This study aims to present a new intelligent polymeric nano-system used for combining chemotherapy with non-viral gene therapy against human cancers. An amphiphilic copolymer synthesized through the conjugation of low molecular weight polyethyleneimine (LMw-PEI) and poly(ε-caprolactone) (PCL) via a bio-cleav...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Davoodi P,Srinivasan MP,Wang CH

    更新日期:2016-07-15 00:00:00

  • Surgical suture assembled with polymeric drug-delivery sheet for sustained, local pain relief.

    abstract::Surgical suture is a strand of biocompatible material designed for wound closure, and therefore can be a medical device potentially suitable for local drug delivery to treat pain at the surgical site. However, the preparation methods previously introduced for drug-delivery sutures adversely influenced the mechanical s...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Lee JE,Park S,Park M,Kim MH,Park CG,Lee SH,Choi SY,Kim BH,Park HJ,Park JH,Heo CY,Choy YB

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    abstract::Recently, the ligament-bone (LTB) junction has been emphasized for the effective transmission of mechanical force and the reduction in stress concentration between the soft ligament and hard bone tissue. The aim of this study was to regenerate an integrated LTB interface by inoculating LTB-relevant cells, isolated fro...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Lee J,Choi WI,Tae G,Kim YH,Kang SS,Kim SE,Kim SH,Jung Y,Kim SH

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Park KS,Kim BJ,Lih E,Park W,Lee SH,Joung YK,Han DK

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    pub_type: 杂志文章


    authors: Shi M,Zhou Y,Shao J,Chen Z,Song B,Chang J,Wu C,Xiao Y

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    pub_type: 杂志文章


    authors: Atefyekta S,Pihl M,Lindsay C,Heilshorn SC,Andersson M

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    pub_type: 杂志文章


    authors: Gyenes T,Torma V,Gyarmati B,Zrínyi M

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Szczesny SE,Elliott DM

    更新日期:2014-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Saito E,Liu Y,Migneco F,Hollister SJ

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Song X,Sun Z,Chen G,Shang P,You G,Zhao J,Liu S,Han D,Zhou H

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    pub_type: 杂志文章


    authors: Huang BJ,Hu JC,Athanasiou KA

    更新日期:2016-10-01 00:00:00

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    abstract:UNLABELLED:Cellular microenvironments present cells with multiple stimuli, including not only soluble biochemical and insoluble matrix cues but also mechanical factors. Biomaterial array platforms have been used to combinatorially and efficiently probe and define two-dimensional (2D) and 3D microenvironmental cues to g...

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    pub_type: 杂志文章


    authors: Liu H,Usprech J,Sun Y,Simmons CA

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    abstract::The deposition of fibronectin (FN) from saline buffer-based cryogenic targets by matrix-assisted pulsed laser evaporation (MAPLE) onto silicon substrates is reported. A uniform distribution of FN was revealed by Ponceau staining after control experiments on nitrocellulose paper. Well-organized particulates with height...

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    pub_type: 杂志文章


    authors: Sima F,Davidson P,Pauthe E,Sima LE,Gallet O,Mihailescu IN,Anselme K

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  • Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species.

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Li M,Chen X,Yan J,Zhou L,Wang Y,He F,Lin J,Zhu C,Pan G,Yu J,Pei M,Yang H,Liu T

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    pub_type: 杂志文章


    authors: Yahyazadehfar M,Zhang D,Arola D

    更新日期:2016-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Zhu X,Dong N,Wang Z,Ma Z,Zhang L,Ma Q,Shan A

    更新日期:2014-01-01 00:00:00

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    abstract::Human embryonic stem cells (hESC) are promising for use in regenerative medicine applications because of their strong proliferative ability and multilineage differentiation capability. To date there have been no reports on hESC seeding with calcium phosphate cement (CPC). The objective of this study was to investigate...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Tang M,Chen W,Weir MD,Thein-Han W,Xu HH

    更新日期:2012-09-01 00:00:00

  • Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds.

    abstract::We here present the first successful report on combining nanostructured silk and poly(ε-caprolactone) (PCL) with a ceramic scaffold to produce a composite scaffold that is highly porous (porosity ∼85%, pore size ∼500 μm, ∼100% interconnectivity), strong and non-brittle with a surface that resembles extracellular matri...

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    pub_type: 杂志文章


    authors: Roohani-Esfahani SI,Lu ZF,Li JJ,Ellis-Behnke R,Kaplan DL,Zreiqat H

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    pub_type: 杂志文章


    authors: Picheth G,Houvenagel S,Dejean C,Couture O,Alves de Freitas R,Moine L,Tsapis N

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    abstract::The mechanical and electrical properties of polycaprolactone fumarate-polypyrrole (PCLF-PPy) scaffolds were studied under physiological conditions to evaluate their ability to maintain the material properties necessary for application as conductive nerve conduits. PC12 cells cultured on PCLF-PPy scaffolds were stimula...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Moroder P,Runge MB,Wang H,Ruesink T,Lu L,Spinner RJ,Windebank AJ,Yaszemski MJ

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  • Influence of fluoride and chloride on corrosion behavior of NiTi orthodontic wires.

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Li X,Wang J,Han EH,Ke W

    更新日期:2007-09-01 00:00:00

  • Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films.

    abstract::In vitro cell culture models representing the physiological and pathological features of the outer retina are urgently needed. Artificial tissue replacements for patients suffering from degenerative retinal diseases are similarly in great demand. Here, we developed a co-culture system based solely on the use of human ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Calejo MT,Saari J,Vuorenpää H,Vuorimaa-Laukkanen E,Kallio P,Aalto-Setälä K,Miettinen S,Skottman H,Kellomäki M,Juuti-Uusitalo K

    更新日期:2020-01-01 00:00:00

  • Modulation of MAPK signalling by immobilized adhesive peptides: Effect on stem cell response to BMP-9-derived peptides.

    abstract:UNLABELLED:Biomimetic materials were developed to regulate stem cell behaviour. We have analyzed the influence of polycaprolactone (PCL) films, functionalized with adhesive peptides derived from fibronectin (pFibro) or bone sialoprotein (pBSP), on the response of murine multipotent C3H10T1/2 cells to bone morphogenetic...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Beauvais S,Drevelle O,Lauzon MA,Daviau A,Faucheux N

    更新日期:2016-02-01 00:00:00

  • A straightforward approach to enhance the textural, mechanical and biological properties of injectable calcium phosphate apatitic cements (CPCs): CPC/blood composites, a comprehensive study.

    abstract::Two commercial formulations of apatitic calcium phosphate cements (CPCs), Graftys® Quickset (QS) and Graftys® HBS (HBS), similar in composition but with different initial setting time (7 and 15min, respectively), were combined to ovine whole blood. Surprisingly, although a very cohesive paste was obtained after a few ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Mellier C,Lefèvre FX,Fayon F,Montouillout V,Despas C,Le Ferrec M,Boukhechba F,Walcarius A,Janvier P,Dutilleul M,Gauthier O,Bouler JM,Bujoli B

    更新日期:2017-10-15 00:00:00

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    abstract::Recent advances in biomaterials integrate metal nanoparticles with hydrogels to generate composite materials that exhibit new or improved properties. By precisely controlling the composition, arrangement and interactions of their constituents, these hybrid materials facilitate biomedical applications through myriad ap...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审


    authors: Clasky AJ,Watchorn JD,Chen PZ,Gu FX

    更新日期:2020-12-19 00:00:00

  • An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway.

    abstract::Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing the immunotherapeutic efficacy. Effectively blocking the ARG1 pathway remains a challenge. L-norvaline is a very cheap and negligible side effects inhibitor of ARG1. However, its blockage efficacy for ARG1 is impeded by its high half-maxi...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Ren X,Wang N,Zhou Y,Song A,Jin G,Li Z,Luan Y

    更新日期:2021-01-29 00:00:00

  • Slipping vs sticking: water-dependent adhesive and frictional properties of Linum usitatissimum L. seed mucilaginous envelope and its biological significance.

    abstract::Flax seeds produce mucilage after wetting. The mucilage due to its ability to absorb and maintain water is responsible for specific surface properties which are essential for seed dispersal in different ways. In the present paper, we asked how the hydration level affects the adhesive and frictional properties of the m...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Kreitschitz A,Kovalev A,Gorb SN

    更新日期:2015-04-01 00:00:00

  • Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications.

    abstract::Synthetic polymer microarray technology holds remarkable promise to rapidly identify suitable biomaterials for stem cell and tissue engineering applications. However, most of previous microarrayed synthetic polymers do not possess biological ligands (e.g., peptides) to directly engage cell surface receptors. Here, we ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Jia J,Coyle RC,Richards DJ,Berry CL,Barrs RW,Biggs J,James Chou C,Trusk TC,Mei Y

    更新日期:2016-11-01 00:00:00

  • The effects of pulsed electromagnetic field on the functions of osteoblasts on implant surfaces with different topographies.

    abstract::The use of pulsed electromagnetic fields (PEMFs) is a promising approach to promote osteogenesis. However, few studies have reported the effects of this technique on the osseointegration of endosseous implants, especially with regard to different implant topographies. We focused on how the initial interaction between ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Wang J,An Y,Li F,Li D,Jing D,Guo T,Luo E,Ma C

    更新日期:2014-02-01 00:00:00