Long-term prognosis after surgery for infective endocarditis: Distinction between predictors of early and late survival.


OBJECTIVES:Cardiac surgery is a life-saving procedure in patients diagnosed with infective endocarditis (IE). There are several validated risk scores developed to predict early-mortality; nevertheless, long-term survival has been less investigated. The aim of the present study is to analyze the impact of IE-specific risk factors for early and long-term mortality. METHODS:An observational retrospective study was conducted that included all patients who underwent surgery for IE from 2002 to 2016. Median follow-up time after surgery was 53.2 months (IQI 26.2-106.8 months). In-hospital mortality was analyzed using multiple logistic regression. Long-term survival was analyzed after one, two and five years. Cox proportional hazards regression was employed to identify risk factors related to long-term mortality. RESULTS:Of the 180 patients underwent cardiac surgery, 133 were discharged alive (in-hospital mortality was 26.11%). 6 variables were identified as independent factors associated with in-hospital mortality, most of them closely related to the severity of IE: age, multivalvular involvement, critical preoperative status, preoperative mechanical ventilation, abscess and thrombocytopenia. Long-term survival in patients discharged alive was 89.1%, 87.4% and 77.6% after one, two and five years. Long-term mortality was independent of specific IE factors and 86.51% of deaths were not related to cardiovascular or infectious diseases. CONCLUSION:Despite the high perioperative mortality rate after surgical treatment for active IE, long-term survival after hospital discharge was acceptable, regardless of the severity of the endocarditis episode. Although in-hospital survival depended mainly on several IE factors, long-term survival was not related to the severity of endocarditis baseline affection.


Varela Barca L,López-Menéndez J,Navas Elorza E,Moya Mur JL,Centella Hernéndez T,Redondo Palacios A,Fajardo ER,Miguelena Hycka J,Martín García M,Muñoz Pérez R,Rodríguez-Roda Stuart J




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2019-01-01 00:00:00














  • Clinical and microbiological characteristics of unusual manifestations of invasive pneumococcal disease.

    abstract:INTRODUCTION:Invasive pneumococcal disease (IPD) typically presents as bacterial pneumonia, meningitis or primary bacteraemia. However, Streptococcus pneumoniae can produce infection at any level of the body (endocarditis, arthritis, spontaneous bacterial peritonitis, etc.), which is also known as unusual IPD (uIPD). T...

    journal_title:Enfermedades infecciosas y microbiologia clinica

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    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


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    journal_title:Enfermedades infecciosas y microbiologia clinica

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    journal_title:Enfermedades infecciosas y microbiologia clinica

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,多中心研究


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    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


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    更新日期:2017-01-01 00:00:00

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    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


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    journal_title:Enfermedades infecciosas y microbiologia clinica

    pub_type: 杂志文章


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    journal_title:Enfermedades infecciosas y microbiologia clinica

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