Abstract:
PURPOSE:Survival in people living with HIV (PLWH) has increased and thus people are aging with HIV, increasing the frequency of multimorbidity and polypharmacy. This cross-sectional study was conducted to evaluate the prevalence of polypharmacy among PLWH who were on antiretroviral treatment and were followed in an outpatient setting by the pharmacy department of several hospitals across Spain. In addition, we aimed to evaluate factors associated with polypharmacy and treatment complexity among this population. MATERIAL AND METHODS:We recorded information on demographic data, data on disease control including viral load and CD4 count at the time of inclusion, comorbidities, pharmacologic treatment and drugs interactions. Polypharmacy was defined as the use of 6 or more different drugs, including antiretroviral medication; major polypharmacy was defined as the use of ≥11 different drugs. RESULTS:Overall, 1225 PLWH were eligible in the study. The median (IQR) age was 49 (40-54). Comorbidities were present in 819 (67%) PLWH and 571 (47%) had two or more comorbidities. Overall, 397 (32.4%, 95% CI 29.8-34.9) PLWH met the criteria for polypharmacy, and 67 (5.5%, 95% CI, 4.2-6.7) had major polypharmacy. Several factors were associated with polypharmacy such as type of antiretroviral treatment, presence of potential interactions, the use of several types of medications and the number of comorbidities. Treatment complexity was also a factor strongly associated with polypharmacy; for each point increase in the medication regimen complexity index (MRCI), the likelihood of polypharmacy increased 2.3-fold. CONCLUSIONS:Polypharmacy is frequent among PLWH in Spain and contributes to a relevant extent to treatment complexity.
journal_name
Enferm Infecc Microbiol Clinjournal_title
Enfermedades infecciosas y microbiologia clinicaauthors
Morillo-Verdugo R,Sánchez-Rubio-Ferrández J,Gimeno-Gracia M,Robustillo-Cortés MLA,Almeida-González CV,POINT study group.doi
10.1016/j.eimc.2020.09.020subject
Has Abstractpub_date
2020-11-20 00:00:00eissn
0213-005Xissn
1578-1852pii
S0213-005X(20)30317-7pub_type
杂志文章abstract:BACKGROUND:Visceral leishmaniasis (VL) is an endemic parasitosis in Spain with a frequency which is increasing, specially among those patients with HIV infection. METHODS:The clinical characteristics of 36 episodes of VL in 20 patients with HIV infection diagnosed in the authors' center from January 1988 to October 19...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Streptococcus pyogenes is a bacteria which, at present, is seldom isolated in blood and articular fluid. An intravenous drug addict with human immunodeficiency virus infection, with bacteremia and arthritis by S. pyogenes, associated with tuberculosis is presented. METHODS:Blood and articular fluid cultures...
journal_title:Enfermedades infecciosas y microbiologia clinica
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doi:
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abstract::Epidemiological surveillance of HIV infection has made notably progress over the last decade, improving knowledge of its characteristics and adapting treatment accordingly. On the other hand, the delayed diagnosis of HIV infection is still an important problem to reduce transmission and improve epidemic control both n...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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abstract:INTRODUCTION AND OBJECTIVES:The primary aim of this study was to evaluate associated factors, clinical features and prognosis of healthcare-related infective endocarditis cases compared with community-acquired and intravenous drug user-related episodes. Changes in the distribution of healthcare-related infective endoca...
journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 共识发展会议,杂志文章,实务指引
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:The purpose of this work was to study the molecular basis of beta-lactamase production in ampicillin-resistant strains of Salmonella spp. METHODS:It was performed analytical isoelectric focusing of beta-lactamases produced by a group of 33 strains selected in basis of their resistance phenotype. Plasmid pro...
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,多中心研究
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更新日期:1998-08-01 00:00:00
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,多中心研究
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journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Multiresistant Gram-negative bacteria represent a major health problem worldwide. This is related to the severity of the infections they cause, the difficulties for empiric (even directed) treatment, the ease of multiresistance spread, and the absence of new antimicrobial agents active against this group of pathogens....
journal_title:Enfermedades infecciosas y microbiologia clinica
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00