Abstract：
:A comprehensive study of fragmentation pathways of 15-membered azalide macrocycles using electrospray ionisation with multistage mass spectrometry (ESI-MS(n)) is presented in this work. Hydrogen/deuterium (H/D) exchange experiments and high-resolution mass spectrometry were used to investigate the proposed fragmentation pathways. In addition, the fragmentation patterns of sodium adduct ions [M+Na](+) of the macrocycles were also investigated as the presence of an alkali metal interacting with the aglycone ring influences the product-ion spectra.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Gembarovski D,Marković VG,Galić Ndoi
10.1016/j.jpba.2013.07.011subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1-10eissn
0731-7085issn
1873-264Xpii
S0731-7085(13)00307-5journal_volume
86pub_type
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