Abstract：
BACKGROUND:Metabolomics could provide valuable insights into hypoxemic-ischemic encephalopathy (HIE) revealing new disease-associated biochemical derangements. The study aimed to investigate urine metabolic changes in neonates with HIE compared to healthy controls, using targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS). PATIENTS AND METHODS:In this prospective, single-center study we enrolled neonates born at ≥ 36 weeks gestation with HIE (HIE group) and healthy controls (control group). We collected urine samples for metabolomic analysis on days one, three, and nine of life. RESULTS:Twenty-one full-term newborns were studied, 13 in the HIE group and eight in the control group. Six of the affected neonates had moderate/severe HIE and seven mild HIE. Therapeutic hypothermia was applied only in four neonates with moderate/severe HIE. Multivariate and univariate statistical analysis showed a clear separation between the HIE and the control groups. Discriminant metabolites involved pyruvic acid, amino acids, acylcarnitines, inositol, kynurenine, hippuric acid, and vitamins. CONCLUSIONS:We have identified a specific metabolic profile in neonates with HIE, adding to the existing knowledge on the disease biochemistry that may potentially help in biomarker development. HIPPOKRATIA 2017, 21(2): 80-84.
journal_name
Hippokratiajournal_title
Hippokratiaauthors
Sarafidis K,Efstathiou N,Begou O,Soubasi V,Agakidou E,Gika E,Theodoridis G,Drossou Vsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
80-84issue
2eissn
1108-4189issn
1790-8019journal_volume
21pub_type
杂志文章相关文献
Hippokratia文献大全abstract：BACKGROUND/AIM:Respiratory syncytial virus (RSV) is one of the main causes of bronchiolitis and pneumonia in infants and young children. The aims of the present study were to evaluate the role of RSV in children >2 years old hospitalized with community-acquired pneumonia (CAP) and to type the circulating RSV strains. ...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:Schwannomas are generally benign, slow growing tumors, which can originate from any nerve that has a Schwann cell sheath. Digestive tract schwannomas are rare and are usually asymptomatic. We present the case of a 48-year-old woman with a symptomatic submucosal tumour of the gastric antrum. The patient underwent parti...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:The rate of operative vaginal delivery has remained stable the last decade, however the rate of vacuum has increased against forceps application. Different maternal and neonatal outcomes have been proposed by many reports. The aim of the present study is to compare the short term maternal and neonatal outcom...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Pediatric home care has improved therapeutic options for children with chronic disease. Home intravenous (IV) antibiotic treatment against Pseudomonas aeruginosa (PsA) in cystic fibrosis (CF) patients has offered increased flexibility to these patients and family life. A prospective clinical study was conduc...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:We evaluated the effects of tobacco smoking on functional outcomes of septoplasty and complication rates. METHODS:In total, 183 patients (127 males, 56 females) who had septum deviations and underwent septoplasties from January 2012 to December 2013 were evaluated. Subjects were divided into three groups: n...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
abstract：:Advances in the field of kidney transplantation have led to a significant increase in the life of renal allograft with 1-year graft survival rates of 93% to 99%. This increase in early graft survival has made it possible to observe the long-term morbidities that accompany renal transplantation. Studies correlating the...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Cardiovascular manifestations are very common in patients with end stage renal disease and those undergoing dialysis treatment. One of the factors, causing cardiovascular disorders due to mineral metabolism disturbances in uremia is the appearance of cardiovascular calcification. The precise mechanism of the mineral m...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Exhaust emissions from motor vehicles threaten the environment and human health. Carbon monoxide (CO) poisoning, especially the use of exhaust gas CO in suicidal attempts is well known in the literature. Recently, indoor car wash facilities established in large shopping malls with closed parking, lots is a n...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/AIM:The aim of this study was to compare three drugs for pain relief during shock wave lithotripsy (SWL). MATERIALS AND METHODS:Seventy six male patients that were treated for renal stones with SWL were included in this study. They were randomized into four groups. A different treatment protocol was used ...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:In the recent years, a new group of designer drugs, under the brand name of bath salts has emerged as a new trend. They are mainly b-ketone amphetamine analogs and are derivatives of cathinone, a monoamine alkaloid. They are abused for psychostimulant effects. Their primary ingredient 3,4-methylenedioxypyrov...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adolescents. Obesity is a major risk factor for NAFLD; however, it has been shown that NAFLD is not rare in non-obese adults. The aim of this study was to determine the prevalence of NAFLD in obese and ...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Barrett's esophagus(BE) is a premalignant condition associated with chronic gastro-esophageal reflux disease (GERD). As only a small proportion of BE progresses to malignancy, it is important to study BE prevalence to prevent adenocarcinoma. MATERIALS AND METHODS:Between January 2007 and December 2010, all ...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Wernicke's encephalopathy is a reversible, neurologic disorder due to thiamine deficiency which is mainly related to chronic alcohol abuse. We report a case of a young male patient, who was bodybuilder and anabolic drug user, in whom encephalopathy was diagnosed after a short medical course in the ICU after a major up...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Trigger pain points are commonly found on the trunk, especially in the neck and shoulders. Dry needling is an effective treatment option in musculoskeletal pain caused by trigger pain points. CASE DESCRIPTION:A 28-year-old female patient who had persistent upper back pain underwent dry needling on both rhom...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:In the present prospective cross-sectional clinical study, correlations between global quality of life (QoL) and coping strategies were examined in patients who had undergone partial laryngeal resection for T1-T2 laryngeal cancer. METHODS:Correlations between point scores in the "Trier Illness Coping Scale...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:To investigate if pepsin is detected, with an activity assay, in the saliva of patients with a clinical diagnosis of laryngopharyngeal reflux (LPR) and can therefore be used as a diagnostic marker of laryngopharyngeal reflux. STUDY DESIGN:Pilot, prospective study. METHODS:Adult participants with a clinical...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Cerebral thromboembolism is a rare, but well-recognized complication of angiographic procedures. Peduncular hallucinosis (PH) is a form of complex visual hallucinations usually associated with lesions in the midbrain and thalamus. CASE PRESENTATION:We report the case of a 79-years-old male patient with inte...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND AND AIM:Νon-motor symptoms in Parkinson's disease (PD) are very common and contribute to the severity of patient's disability. We evaluated the frequency of nonmotor symptoms in patients with PD and we explored the influence of disease characteristics on the presence of these symptoms. PATIENTS AND METHODS:...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND AND AIM:The diagnosis of peripheral diabetic neuropathy is based on clinical examination. Nerve conduction study (NCS) enables earlier diagnosis, but it is demanding and requires specialised personnel. In an attempt to simplify the procedure, this study aimed to identify a new electrophysiological index, whi...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:To investigate an outbreak of Burkholderia cenocepacia bacteremia. Observational study and chart review in a multidisciplinary adult Intensive Care Unit (ICU) at a tertiary care hospital. METHODS:Patients' demographic variables, comorbid conditions, ICU admission diagnosis, disease severity and outcome were...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:Multiple myeloma is a haematologic malignancy caused by clonal expansion of malignant plasma cells and associated with bone disease and hypercalcaemia. Myeloma cells are in close proximity to sites of active bone resorption and the interactions between those cells, osteoblasts and osteoclasts, are crucial not only for...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Subacute superior mesenteric vein thrombosis is a rare ischemic intestinal disease which is often characterized by delayed diagnosis due to obscure clinical picture. CASE REPORT:A 67-year-old woman who presented chronic abdominal pain with mild nausea due to superior mesenteric vein thrombosis was submitted...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND: Resistance to thyroid hormone (RTH) is a rare dominantly inherited disorder mainly due to variants in the THRB gene leading to decreased end-organ responsiveness to thyroid hormones. CASE REPORT:Clinical and molecular characteristics of four patients with RTH are described. Four patients with various phen...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:A variety of organisms produce potent toxins that impact human health through compromising respiratory function. CASE REPORT:We describe a rare case of abrupt respiratory failure afterNicotiana glaucaingestion in a previously healthy sixty years old female patient. She presented complaining for gait instabi...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated disease of the peripheral nervous system characterized by motor weakness, sensory symptoms, areflexia, and specific electrophysiological findings. Rarely, Anti-Tumor Necrosis Factor-alpha (anti-TNFa) agents, which are used as ...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2019-10-01 00:00:00
abstract：:Intravenous (IV) paracetamol is widely used for the treatment of pain and fever, when there is a clinical indication for an IV route. A 16-month-old girl weighing 12 kg had undergone anterior open reduction for developmental dysplasia of the hip. Twenty-four hours after the operation, IV paracetamol (Perfalgan® 10 mg/...
journal_title：Hippokratia
pub_type：
doi：
更新日期：2013-01-01 00:00:00
abstract：AIM:This study investigated the utility of the alveolar-arterial (AaDO2) gradient in predicting the short-term prognosis of submassive pulmonary embolism (PE). MATERIAL AND METHODS:This study retrospectively enrolled 124 patients with acute submassive PE. During the first 24 h of admission, all patients had initial ar...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：:Diabetic nephropathy is a serious, long-term complication of diabetes and the leading cause of end-stage renal disease throughout the world. Although this disease is progressively imposing a heavier burden on the health care system, in many aspects it remains poorly understood. In addition to environmental influences,...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:This study was performed to investigate nutritional parameters of hemodialysis patients by using anthropometric and biochemical measurements. METHODS:Data from the last 6 months of 22 adult hemodialysis patients with a mean age of 61 ± 14 years were analyzed retrospectively. Dialysis vintage, normalized pro...
journal_title：Hippokratia
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:Vitamin D has many physiological functions. First it is a primary regulator of calcium homeostasis. Beyond that, vitamin D and its receptors (VDR) play important role in the immune system, cardiovascular system, reproductive system and insulin resistance. An important aspect of vitamin D pleiotropic effects is the int...
journal_title：Hippokratia
pub_type： 杂志文章,评审
doi：
更新日期：2011-10-01 00:00:00
