Abstract:
BACKGROUND:Pediatric home care has improved therapeutic options for children with chronic disease. Home intravenous (IV) antibiotic treatment against Pseudomonas aeruginosa (PsA) in cystic fibrosis (CF) patients has offered increased flexibility to these patients and family life. A prospective clinical study was conducted to compare safety, efficacy, and cost benefits of home versus hospital IV antibiotic treatment among CF children and adolescents. METHOD:The clinical outcome, quality of life, and cost benefits of home versus hospital antibiotic treatment were assessed. The clinical outcome was evaluated with Forced Expiratory Volume in one second (FEV1) and weight gain before and one month after antibiotic treatment, while the Quality of life was evaluated using the DISABKIDS questionnaire. Cost analysis was performed to calculate cost benefits from home IV treatment. RESULTS:Thirty-five stable patients with CF (mean age: 12.6 ± 7 years, 56 % male, mean FEV1: 83.5 ± 26 %), colonized with PsA, were treated with IV antibiotics for two weeks either in the hospital (15 patients), or at home (20 patients) under supervision by a home care nurse. Lung function (FEV1) and weight improved significantly in both groups (ΔFEV1% =7.7 ± 6.1, p <0.001; ΔWeight =1.2 ± 0.8, p <0.001). Hospital treatment did not show a better clinical outcome, compared to home treatment (ΔFEV1, p =0.606; ΔWeight, p =0.608). Both improvements in the quality of life and economical savings were substantial (p <0.001) regarding patients treated at home. Also, patients treated at home did not report any significant side effects or complications. CONCLUSIONS:Home IV antibiotic therapy monitored by a home care nurse, is a safe, efficient, and cost-saving therapeutic option in CF. Hippokratia 2016, 20(4): 279-283.
journal_name
Hippokratiajournal_title
Hippokratiaauthors
Chrysochoou EA,Hatziagorou E,Kirvassilis F,Tsanakas Jsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
279-283issue
4eissn
1108-4189issn
1790-8019journal_volume
20pub_type
杂志文章相关文献
Hippokratia文献大全abstract:OBJECTIVES:To investigate if pepsin is detected, with an activity assay, in the saliva of patients with a clinical diagnosis of laryngopharyngeal reflux (LPR) and can therefore be used as a diagnostic marker of laryngopharyngeal reflux. STUDY DESIGN:Pilot, prospective study. METHODS:Adult participants with a clinical...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Crimean-Congo hemorrhagic fever (CCHF) is a viral disease with fatality rate up to 30%. Up to date, only one CCHF case has been reported in Greece, while a distinct virus strain (AP92) had been isolated in 1975 from ticks in Imathia prefecture, northern Greece. The aim of the present study was to estimate th...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2013-10-01 00:00:00
abstract::The European Union (EU) and the world are faced with unprecedented economic challenges, which if allowed to persist could threaten its continued existence in its current form as a union. Furthermore, these same financial challenges can easily translate into societal hardship. The biomedical and pharmaceutical industri...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the disease characteristics of children with juvenile idiopathic arthritis (JIA) in southeast Turkey. METHODS:The International League of Associations for Rheumatology (ILAR) criteria were used to diagnose JIA. Hospital records of the Pediatric Rheumatology Unit, of ...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::Multiple myeloma is a haematologic malignancy caused by clonal expansion of malignant plasma cells and associated with bone disease and hypercalcaemia. Myeloma cells are in close proximity to sites of active bone resorption and the interactions between those cells, osteoblasts and osteoclasts, are crucial not only for...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Computer-aided detection in the setting of trauma presents unique challenges due to variations in shape and attenuation of the injured organs based on the timing and severity of the injury. We developed and validated an automated computer-aided diagnosis algorithm to detect splenic lesions such as laceratio...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Severe immune thrombocytopenia displays a rare side effect of pegylated interferon therapy for Hepatitis C infection. Our aim is to report a case of severe and late onset immune thrombocytopenia due to pegylated interferon treatment that was effectively managed with the anti-CD20 monoclonal antibody Rituxima...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) represents less than 0.1% of all tumors, but it is considered the most common skin sarcoma. Wide local excision (=5 cm) has been largely replaced by Mohs micrographic surgery; however, recurrence is not rare. Description of the case: A 35-year-old man presented with a l...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Recent studies provide evidence that peripheral blood monocytes have the ability to differentiate into mesenchymal-like cells. The ability of cultured monocytes to differentiate and produce insulin in vitro is analysed in the present study. METHODS:Peripheral blood monocytes were isolated from healthy donor...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Bone involvement represents a common symptom at diagnosis in children with acute lymphoblastic leukemia, and its prognostic value is not entirely clarified. The aim of this study was to evaluate bone involvement at diagnosis in children with acute lymphoblastic leukemia as a predictive factor and to correlat...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Subacute superior mesenteric vein thrombosis is a rare ischemic intestinal disease which is often characterized by delayed diagnosis due to obscure clinical picture. CASE REPORT:A 67-year-old woman who presented chronic abdominal pain with mild nausea due to superior mesenteric vein thrombosis was submitted...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2011-07-01 00:00:00
abstract::Alveolar soft-part sarcoma (ASPS) is a rare form of soft tissue sarcoma and is most often seen in adolescents and young adults. Surgical excision of the primary tumor and pulmonary metastases has resulted in prolonged survival in some patients while the benefit of adjuvant chemotherapy and/or radiotherapy has been dis...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2008-01-01 00:00:00
abstract::Congenital, X-linked, Nephrogenic Diabetes Insipidus (NDI) is a rare disorder in which the kidney is insensitive to the antidiuretic hormone, vasopressin. The gene responsible for this type of NDI, the V2 vasopressin receptor, has been cloned and mapped to Xq28. We report the case of a boy, 2.5 month old, who presente...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2011-10-01 00:00:00
abstract:AIM:The aim of the current study was to evaluate the level of the basic knowledge of the Turkish gynecologists regarding electrosurgery. MATERIALS AND METHODS:A survey was undertaken to evaluate the level of basic knowledge and attitudes regarding electrosurgery use among gynecology specialists and residents. The ques...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2017-01-01 00:00:00
abstract::The introduction of erythropoietin (Epo) in clinical practice, more than two decades ago, altered completely the management of patients with chronic kidney disease (CKD). The successful correction of anemia of CKD has resulted in reduction of associated morbidity and improvement of functionality, exercise tolerance, c...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract::Primary cytomegalovirus infection is rare among immunocompetent hosts. We present a case of acute cytomegalovirus infection in a young immunocompetent female with pulmonary and hepatic involvement, admitted to our department due to severe exertional dyspnea. Patient's symptoms were completely atypical. Ganciclovir was...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Acute exacerbations of respiratory diseases are a common cause of hospitalization among infants and children. AIM:To assess the epidemiological characteristics of asthma, bronchiolitis and croup among hospitalized children in Thessaloniki, from 1990 to 2003 included. METHODS:Data from the patient registry ...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
abstract:UNLABELLED:The recent engagement of Brazil in the construction and utilization of the International Space Station has motivated several Brazilian research institutions and universities to establish study centers related to Space Sciences. The Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) is no exception...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:This study was performed to investigate nutritional parameters of hemodialysis patients by using anthropometric and biochemical measurements. METHODS:Data from the last 6 months of 22 adult hemodialysis patients with a mean age of 61 ± 14 years were analyzed retrospectively. Dialysis vintage, normalized pro...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to compare three drugs for pain relief during shock wave lithotripsy (SWL). MATERIALS AND METHODS:Seventy six male patients that were treated for renal stones with SWL were included in this study. They were randomized into four groups. A different treatment protocol was used ...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND AIM:Νon-motor symptoms in Parkinson's disease (PD) are very common and contribute to the severity of patient's disability. We evaluated the frequency of nonmotor symptoms in patients with PD and we explored the influence of disease characteristics on the presence of these symptoms. PATIENTS AND METHODS:...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2013-07-01 00:00:00
abstract::Vitamin D has many physiological functions. First it is a primary regulator of calcium homeostasis. Beyond that, vitamin D and its receptors (VDR) play important role in the immune system, cardiovascular system, reproductive system and insulin resistance. An important aspect of vitamin D pleiotropic effects is the int...
journal_title:Hippokratia
pub_type: 杂志文章,评审
doi:
更新日期:2011-10-01 00:00:00
abstract:AIM:This study investigated the utility of the alveolar-arterial (AaDO2) gradient in predicting the short-term prognosis of submassive pulmonary embolism (PE). MATERIAL AND METHODS:This study retrospectively enrolled 124 patients with acute submassive PE. During the first 24 h of admission, all patients had initial ar...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in remodeling the extracellular matrix. Tissue inhibitors of metalloproteinases (TIMPs) are a family of four proteins that act to limit the degradative actions of MMPs. Chronic kidney disease (CKD) and acute kidney injury ...
journal_title:Hippokratia
pub_type: 杂志文章,评审
doi:
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The rate of operative vaginal delivery has remained stable the last decade, however the rate of vacuum has increased against forceps application. Different maternal and neonatal outcomes have been proposed by many reports. The aim of the present study is to compare the short term maternal and neonatal outcom...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Diabetic nephropathy is a serious, long-term complication of diabetes and the leading cause of end-stage renal disease throughout the world. Although this disease is progressively imposing a heavier burden on the health care system, in many aspects it remains poorly understood. In addition to environmental influences,...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
abstract::Cardiovascular manifestations are very common in patients with end stage renal disease and those undergoing dialysis treatment. One of the factors, causing cardiovascular disorders due to mineral metabolism disturbances in uremia is the appearance of cardiovascular calcification. The precise mechanism of the mineral m...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::The myelodysplastic syndromes (MDS) remain challenging to the clinician in terms of diagnosis and management. The diagnosis is essentially one of exclusion in first ruling out other disorders that can also cause peripheral blood/bone marrow cell dysplasia and cytopenias. Recent studies implicate extensive apoptosis as...
journal_title:Hippokratia
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND: Resistance to thyroid hormone (RTH) is a rare dominantly inherited disorder mainly due to variants in the THRB gene leading to decreased end-organ responsiveness to thyroid hormones. CASE REPORT:Clinical and molecular characteristics of four patients with RTH are described. Four patients with various phen...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Thyroid transcription factor-1 (TTF-1) has been considered a sensitive marker for thyroid and lung tumors. Recent data have shown that a wide range of neoplasms may express TTF-1. CASE SERIES:We performed an immunohistochemical study in a case series of 42 urothelial carcinomas (UCs) on tissue microarrays s...
journal_title:Hippokratia
pub_type:
doi:
更新日期:2017-07-01 00:00:00