Vascular calcification and metabolic acidosis in end stage renal disease.

Abstract:

:Cardiovascular manifestations are very common in patients with end stage renal disease and those undergoing dialysis treatment. One of the factors, causing cardiovascular disorders due to mineral metabolism disturbances in uremia is the appearance of cardiovascular calcification. The precise mechanism of the mineral metabolism disturbances acting through the existing metabolic acidosis in chronic renal failure is not yet clarified. The influence of acidosis is a complex one, acting as a stimulator of the solubility of Ca-P deposits, a suppressor of parathyroid secretion, an inhibitor of some osteogenic enzymes, a blocker of formation of bone matrix, a modulator of the up-regulation of Pit-1 and finally as a blocker of phosphate uptake by the arterial smooth muscle cells.

journal_name

Hippokratia

journal_title

Hippokratia

authors

Yonova D

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

139-40

issue

3

eissn

1108-4189

issn

1790-8019

journal_volume

13

pub_type

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