S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA2 phosphorylation.

abstract：:The complex dynamic structure of the plasma membrane plays critical roles in cellular signaling; interactions with the membrane lipid milieu, spatial segregation within and between cellular membranes and/or targeting to specific membrane-associated scaffolds are intimately involved in many signal transduction pathways...

journal_title：Cellular signalling

authors： Eisenberg S,Henis YI

更新日期：2008-01-01 00:00:00

abstract：:Homer1 protein is an important scaffold protein at postsynaptic density and has been demonstrated to play a central role in calcium signaling in the central nervous system. The aim of this study was to investigate the effects of Homer1 knockdown on MPP(+) induced neuronal injury in cultured dopamine (DA) neurons. We f...

journal_title：Cellular signalling

authors： Chen T,Yang YF,Luo P,Liu W,Dai SH,Zheng XR,Fei Z,Jiang XF

更新日期：2013-12-01 00:00:00

abstract：:Low glucose stimulated phosphorylation of pregnane X receptor (PXR) at Ser350 in correlation with an increased gluconeogenesis in human hepatoma-derived HepG2 cells. Only glucose, but neither insulin nor glucagon, stimulated this phosphorylation. Here, serine/threonine kinase, vaccinia related kinase 1 (VRK1)-mediated...

journal_title：Cellular signalling

authors： Gotoh S,Miyauchi Y,Moore R,Negishi M

更新日期：2017-12-01 00:00:00

abstract：:Previous studies have shown that RGS4 associates with the C-termini of μ- and δ-opioid receptors in living cells and plays a key role in Gi/Go protein coupling selectivity and signalling of these receptors [12,20]. To deduce whether similar effects also occur for the κ-opioid receptor (κ-ΟR) and define the ability of ...

journal_title：Cellular signalling

authors： Papakonstantinou MP,Karoussiotis C,Georgoussi Z

更新日期：2015-01-01 00:00:00

abstract：:Calcium/calmodulin dependent protein kinase IIδ (CaMKIIδ) acts as a molecular switch regulating cardiovascular Ca2+ handling and contractility in health and disease. Activation of CaMKIIδ is also known to regulate cardiovascular inflammation and is reported to be required for pro-inflammatory NF-κB signalling. In this...

journal_title：Cellular signalling

authors： Martin TP,McCluskey C,Cunningham MR,Beattie J,Paul A,Currie S

更新日期：2018-11-01 00:00:00

abstract：:Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been proposed that the RING fi...

journal_title：Cellular signalling

authors： Wiggins CM,Band H,Cook SJ

更新日期：2007-12-01 00:00:00

abstract：:Five G protein-coupled receptors (GPCRs) for the lysophospholipid sphingosine 1-phosphate (S1P) have been cloned and characterized so far. We report here about the identification of gpr3, gpr6 and gpr12 as additional members of the S1P-GPCR family. When expressed transiently in HEK293 cells, gpr3, gpr6 and gpr12 confe...

journal_title：Cellular signalling

authors： Uhlenbrock K,Gassenhuber H,Kostenis E

更新日期：2002-11-01 00:00:00

abstract：:Human neutrophils pre-incubated with granulocyte-macrophage-colony-stimulating factor (GM-CSF) exhibit an enhanced mobilization of calcium in response to secondary stimuli such as chemotactic factors. The mechanisms underlying this priming effect of GM-CSF were examined. It was first demonstrated that the additional c...

journal_title：Cellular signalling

authors： Naccache PH,Hamelin B,Gaudry M,Bourgoin S

更新日期：1991-01-01 00:00:00

abstract：:Capsaicin (CAP), the pungent ingredient of chili peppers, inhibits growth of various solid cancers via TRPV1 as well as TRPV1-independent mechanisms. Recently, we showed that TRPV1 regulates intracellular calcium level and chromogranin A secretion in pancreatic neuroendocrine tumor (NET) cells. In the present study, w...

journal_title：Cellular signalling

authors： Skrzypski M,Sassek M,Abdelmessih S,Mergler S,Grötzinger C,Metzke D,Wojciechowicz T,Nowak KW,Strowski MZ

更新日期：2014-01-01 00:00:00

abstract：:Mycophenolic acid (MPA), widely used to prevent organ transplant rejection, may induce toxicity and impair function in beta-cells. Mechanisms of MPA-induced cell death have not been fully explored. In this study, we examined gene expression patterns in INS-1E cells and isolated primary rat islets following MPA treatme...

journal_title：Cellular signalling

authors： Park YJ,Ahn HJ,Kim YS,Cho Y,Joo DJ,Ju MK

更新日期：2010-11-01 00:00:00

abstract：:C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. However, relatively little is known about the regulation of C1-Ten, such as changes in its protein leve...

journal_title：Cellular signalling

authors： Koh A,Park D,Jeong H,Lee J,Lee MN,Suh PG,Ryu SH

更新日期：2014-11-01 00:00:00

abstract：:Our previous oligonucleotide array studies revealed that ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL) express high levels of the disheveled proteins (Dvls), a family of proteins that is integral to the Wnt signaling pathways. In this study, we assessed whether the Dvls are important in the pathogenesis of ...

journal_title：Cellular signalling

authors： Hegazy SA,Alshareef A,Gelebart P,Anand M,Armanious H,Ingham RJ,Lai R

更新日期：2013-01-01 00:00:00

abstract：:Characterization of cardiac MYPT2 (an isoform of the smooth muscle phosphatase [MP] target subunit, MYPT1) is described. Several features of MYPT2 and MYPT1 were similar, including: a specific interaction with the catalytic subunit of type 1 phosphatase, delta isoform (PP1cdelta); interaction of MYPT2 with the small h...

journal_title：Cellular signalling

authors： Okamoto R,Kato T,Mizoguchi A,Takahashi N,Nakakuki T,Mizutani H,Isaka N,Imanaka-Yoshida K,Kaibuchi K,Lu Z,Mabuchi K,Tao T,Hartshorne DJ,Nakano T,Ito M

更新日期：2006-09-01 00:00:00

abstract：:It has been shown lately that activity of G protein-coupled receptors (GPCRs) is regulated by an array of proteins binding to carboxy (C)-terminus of GPCRs. Proteins of 4.1 family are subsets of subcortical cytoskeletal proteins and are known to stabilize cellular structures and proteins at the plasma membrane. One of...

journal_title：Cellular signalling

authors： Goto T,Chiba A,Sukegawa J,Yanagisawa T,Saito M,Nakahata N

更新日期：2013-03-01 00:00:00

abstract：:Single disseminated tumor cells (DTC) can be detected in the bone marrow (BM) from 20% to 60% of patients with various tumors including non-small cell lung cancer (NSCLC). Detection of DTC in the BM of NSCLC patients is associated with poor prognosis and may be responsible for metastatic relapse. However, the function...

journal_title：Cellular signalling

authors： Grabinski N,Bartkowiak K,Grupp K,Brandt B,Pantel K,Jücker M

更新日期：2011-12-01 00:00:00

abstract：:Src homology (SH) 3 domains are small modules found in a diverse array of proteins. The presence of an SH3 domain confers upon its resident protein the ability to interact with specific proline-rich sequences in protein binding partners. A major focus of research has highlighted a role for SH3 domain-mediated interact...

journal_title：Cellular signalling

authors： McPherson PS

更新日期：1999-04-01 00:00:00

abstract：:Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinic...

journal_title：Cellular signalling

authors： Fan GH,Zhu TY,Huang J

更新日期：2020-08-01 00:00:00

abstract：:Reelin is a secreted glycoprotein and essential for brain development and plasticity. Recent studies provide evidence that Reelin modifies platelet actin cytoskeletal dynamics. In this study we sought to dissect the contribution of Reelin in arterial thrombus formation. Here we analyzed the impact of Reelin in arteria...

journal_title：Cellular signalling

authors： Gowert NS,Krüger I,Klier M,Donner L,Kipkeew F,Gliem M,Bradshaw NJ,Lutz D,Köber S,Langer H,Jander S,Jurk K,Frotscher M,Korth C,Bock HH,Elvers M

更新日期：2017-12-01 00:00:00

abstract：:The functional role of peroxisome proliferator-activated receptor-beta(PPARbeta; also referred to as PPARdelta) in epidermal cell growth remains controversial. Recent evidence suggests that ligand activation of PPARbeta/delta increases cell growth and inhibits apoptosis in epidermal cells. In contrast, other reports s...

journal_title：Cellular signalling

authors： Burdick AD,Bility MT,Girroir EE,Billin AN,Willson TM,Gonzalez FJ,Peters JM

更新日期：2007-06-01 00:00:00

abstract：:The present study was designed to investigate (i) the role of AMPK activation in inducing autophagy in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia, and (ii) whether autophagy offers a survival advantage under these harsh conditions. Low androgen and low oxygen are two co-exis...

journal_title：Cellular signalling

authors： Chhipa RR,Wu Y,Ip C

更新日期：2011-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the Editors. The Publisher apologises for any inconvenience that this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Cellular signalling

authors： Genestra M

更新日期：2009-03-27 00:00:00

abstract：:Ethanol, in millimolar concentrations, significantly modifies different transductive systems in human lymphocyte cultures. In particular, the presence of alcohol in the medium more than doubles the [Ca2+]i (from 70-90 to 200-250 nM), increasing Ca2+ fluxes from outside, and inhibits the active transport carried out by...

journal_title：Cellular signalling

authors： Fanò G,Belia S,Mariggiò MA,Antonica A,Agea E,Spinozzi F

更新日期：1993-03-01 00:00:00

abstract：:Strong evidence suggests that neutrophils may play an active role in acute and chronic inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. Given the role of pro-inflammatory cytokine TNF-alpha in these inflammatory processes, we planned the present study to investigate the effect of short term in...

journal_title：Cellular signalling

authors： Montecucco F,Steffens S,Burger F,Da Costa A,Bianchi G,Bertolotto M,Mach F,Dallegri F,Ottonello L

更新日期：2008-03-01 00:00:00

abstract：:Cell cycle progression from G2 phase into mitosis is regulated by a complex network of mechanisms, all of which finally control the timing of Cyclin B/CDK1 activation. PLK1 regulates a network of events that contribute to regulating G2/M phase progression. Here we have used a proteomics approach to identify proteins t...

journal_title：Cellular signalling

authors： Pinder A,Loo D,Harrington B,Oakes V,Hill MM,Gabrielli B

更新日期：2015-11-01 00:00:00

abstract：:Dystrophin and the dystrophin-associated protein complex (DAPC) have recently been implicated in cell signalling events. These proteins are ideally placed to transduce signals from the extracellular matrix (ECM) to the cytoskeleton. Here we show that beta-dystroglycan is tyrosine-phosphorylated in C2/C4 mouse myotubes...

journal_title：Cellular signalling

authors： Ilsley JL,Sudol M,Winder SJ

更新日期：2001-09-01 00:00:00

abstract：:Nur77 (NR4A1) plays an important role in various inflammatory responses. Nur77 is rapidly degraded in cells and its protein level is critically controlled. Although few E3 ligases regulating the Nur77 protein have been defined, the deubiquitinase (DUB) responsible for Nur77 stability has not been reported to date. We ...

journal_title：Cellular signalling

authors： Pei HZ,Huang B,Chang HW,Baek SH

更新日期：2019-07-01 00:00:00

abstract：:Neutrophils are key effector cells of the innate immune system, serving as a first line of defense in the response to injury and playing essential roles in the wound healing process. Following myocardial infarction (MI), neutrophils infiltrate into the infarct region to propagate inflammation and begin the initial pha...

journal_title：Cellular signalling

authors： Daseke MJ 2nd,Chalise U,Becirovic-Agic M,Salomon JD,Cook LM,Case AJ,Lindsey ML

更新日期：2021-01-01 00:00:00

abstract：:DMSO differentiated U937 cells responded to 10(-6) M LTD4, LTB4 and FMLP with an increase in both InsP formation and [Ca2+]i. FMLP caused a greater rise in InsPs than either LTD4 or LTB4, which were equivalent. LTD4, however, caused a greater increase in [Ca2+]i than LTB4 (4-fold) or FMLP. The FMLP [Ca2+]i and InsP re...

journal_title：Cellular signalling

authors： Pollock K,Creba J

更新日期：1990-01-01 00:00:00

abstract：:Transforming growth factory beta (TGF-beta) is a potent growth inhibitor of epithelial cells. One of the strategies used to elucidate the anti-proliferative mode of action of TGF-beta is to find out whether the receptor-generated signals interact with components of the basic machinery of the cell cycle. In this study ...

journal_title：Cellular signalling

authors： Landesman Y,Bringold F,Milne DD,Meek DW

更新日期：1997-05-01 00:00:00

abstract：:The stimulatory G protein (Gs) mediates activation of adenylylcyclase by a ligand-receptor complex. Gs is heterotrimeric (alpha beta gamma) and activation can be accomplished by dissociation of the alpha-subunit (Gs alpha) from the beta gamma-subunit complex (G beta gamma). Gs alpha is also a substrate for choleragen ...

journal_title：Cellular signalling

authors： Warner DR,Okuya S,Rebois RV

更新日期：1996-01-01 00:00:00