Change in Brainstem Gray Matter Concentration Following a Mindfulness-Based Intervention is Correlated with Improvement in Psychological Well-Being.

Abstract:

:Individuals can improve their levels of psychological well-being (PWB) through utilization of psychological interventions, including the practice of mindfulness meditation, which is defined as the non-judgmental awareness of experiences in the present moment. We recently reported that an 8-week-mindfulness-based stress reduction (MBSR) course lead to increases in gray matter concentration in several brain areas, as detected with voxel-based morphometry of magnetization prepared rapid acquisition gradient echo MRI scans, including the pons/raphe/locus coeruleus area of the brainstem. Given the role of the pons and raphe in mood and arousal, we hypothesized that changes in this region might underlie changes in well-being. A subset of 14 healthy individuals from a previously published data set completed anatomical MRI and filled out the PWB scale before and after MBSR participation. PWB change was used as the predictive regressor for changes in gray matter density within those brain regions that had previously shown pre- to post-MBSR changes. Results showed that scores on five PWB subscales as well as the PWB total score increased significantly over the MBSR course. The change was positively correlated with gray matter concentration increases in two symmetrically bilateral clusters in the brainstem. Those clusters appeared to contain the area of the pontine tegmentum, locus coeruleus, nucleus raphe pontis, and the sensory trigeminal nucleus. No clusters were negatively correlated with the change in PWB. This preliminary study suggests a neural correlate of enhanced PWB. The identified brain areas include the sites of synthesis and release of the neurotransmitters, norepinephrine and serotonin, which are involved in the modulation of arousal and mood, and have been related to a variety of affective functions as well as associated clinical dysfunctions.

journal_name

Front Hum Neurosci

authors

Singleton O,Hölzel BK,Vangel M,Brach N,Carmody J,Lazar SW

doi

10.3389/fnhum.2014.00033

subject

Has Abstract

pub_date

2014-02-18 00:00:00

pages

33

issn

1662-5161

journal_volume

8

pub_type

杂志文章
  • Brain-to-Brain Coupling in the Gamma-Band as a Marker of Shared Intentionality.

    abstract::Cooperation and competition are two ways of social interaction keys to life in society. Recent EEG-based hyperscanning studies reveal that cooperative and competitive interactions induce an increase in interbrain coupling. However, whether this interbrain coupling effect is just a reflection of inter-subject motor coo...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00295

    authors: Barraza P,Pérez A,Rodríguez E

    更新日期:2020-07-30 00:00:00

  • Non-linear Relationship between BOLD Activation and Amplitude of Beta Oscillations in the Supplementary Motor Area during Rhythmic Finger Tapping and Internal Timing.

    abstract::Functional imaging studies using BOLD contrasts have consistently reported activation of the supplementary motor area (SMA) both during motor and internal timing tasks. Opposing findings, however, have been shown for the modulation of beta oscillations in the SMA. While movement suppresses beta oscillations in the SMA...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00582

    authors: Gompf F,Pflug A,Laufs H,Kell CA

    更新日期:2017-11-30 00:00:00

  • Drift and ownership toward a distant virtual body.

    abstract::In body ownership illusions participants feel that a mannequin or virtual body (VB) is their own. Earlier results suggest that body ownership over a body seen from behind in extra personal space is possible when the surrogate body is visually stroked and tapped on its back, while spatially and temporal synchronous tac...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00908

    authors: Pomés A,Slater M

    更新日期:2013-12-25 00:00:00

  • Brain Activity Associated With Expected Task Difficulty.

    abstract::Previous research shows that people can use a cue to mentally prepare for a cognitive challenge. The response to a cue has been defined as phasic alertness which is reflected in faster responses and increased activity in frontal, parietal, thalamic, and visual brain regions. We examine if and how phasic alertness can ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00286

    authors: de Dreu MJ,Schouwenaars IT,Rutten GM,Ramsey NF,Jansma JM

    更新日期:2019-08-28 00:00:00

  • Aberrant Effective Connectivity in Schizophrenia Patients during Appetitive Conditioning.

    abstract::It has recently been suggested that schizophrenia involves dysfunction in brain connectivity at a neural level, and a dysfunction in reward processing at a behavioral level. The purpose of the present study was to link these two levels of analyses by examining effective connectivity patterns between brain regions medi...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00239

    authors: Diaconescu AO,Jensen J,Wang H,Willeit M,Menon M,Kapur S,McIntosh AR

    更新日期:2011-01-17 00:00:00

  • Efficacy and Brain Imaging Correlates of an Immersive Motor Imagery BCI-Driven VR System for Upper Limb Motor Rehabilitation: A Clinical Case Report.

    abstract::To maximize brain plasticity after stroke, a plethora of rehabilitation strategies have been explored. These include the use of intensive motor training, motor-imagery (MI), and action-observation (AO). Growing evidence of the positive impact of virtual reality (VR) techniques on recovery following stroke has been sho...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00244

    authors: Vourvopoulos A,Jorge C,Abreu R,Figueiredo P,Fernandes JC,Bermúdez I Badia S

    更新日期:2019-07-11 00:00:00

  • A Multi-Target Motor Imagery Training Using Bimodal EEG-fMRI Neurofeedback: A Pilot Study in Chronic Stroke Patients.

    abstract::Traditional rehabilitation techniques present limitations and the majority of patients show poor 1-year post-stroke recovery. Thus, Neurofeedback (NF) or Brain-Computer-Interface applications for stroke rehabilitation purposes are gaining increased attention. Indeed, NF has the potential to enhance volitional control ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00037

    authors: Lioi G,Butet S,Fleury M,Bannier E,Lécuyer A,Bonan I,Barillot C

    更新日期:2020-02-18 00:00:00

  • Metaphors are physical and abstract: ERPs to metaphorically modified nouns resemble ERPs to abstract language.

    abstract::Metaphorical expressions very often involve words referring to physical entities and experiences. Yet, figures of speech such as metaphors are not intended to be understood literally, word-by-word. We used event-related brain potentials (ERPs) to determine whether metaphorical expressions are processed more like physi...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00028

    authors: Forgács B,Bardolph MD,Amsel BD,DeLong KA,Kutas M

    更新日期:2015-02-10 00:00:00

  • Automatic processing of unattended object features by functional connectivity.

    abstract::Observers can selectively attend to object features that are relevant for a task. However, unattended task-irrelevant features may still be processed and possibly integrated with the attended features. This study investigated the neural mechanisms for processing both task-relevant (attended) and task-irrelevant (unatt...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00193

    authors: Mayer KM,Vuong QC

    更新日期:2013-05-15 00:00:00

  • Optic ataxia as a model to investigate the role of the posterior parietal cortex in visually guided action: evidence from studies of patient M.H.

    abstract::Optic ataxia is a neuropsychological disorder that affects the ability to interact with objects presented in the visual modality following either unilateral or bilateral lesions of the posterior parietal cortex (PPC). Patients with optic ataxia fail to reach accurately for objects, particularly when they are presented...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00336

    authors: Cavina-Pratesi C,Connolly JD,Milner AD

    更新日期:2013-07-16 00:00:00

  • Uncertainty in perception and the Hierarchical Gaussian Filter.

    abstract::In its full sense, perception rests on an agent's model of how its sensory input comes about and the inferences it draws based on this model. These inferences are necessarily uncertain. Here, we illustrate how the Hierarchical Gaussian Filter (HGF) offers a principled and generic way to deal with the several forms tha...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00825

    authors: Mathys CD,Lomakina EI,Daunizeau J,Iglesias S,Brodersen KH,Friston KJ,Stephan KE

    更新日期:2014-11-19 00:00:00

  • Situating emotional experience.

    abstract::Psychological construction approaches to emotion suggest that emotional experience is situated and dynamic. Fear, for example, is typically studied in a physical danger context (e.g., threatening snake), but in the real world, it often occurs in social contexts, especially those involving social evaluation (e.g., publ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00764

    authors: Wilson-Mendenhall CD,Barrett LF,Barsalou LW

    更新日期:2013-11-26 00:00:00

  • Histological Confirmation of Myelinated Neural Filaments Within the Tip of the Neurotrophic Electrode After a Decade of Neural Recordings.

    abstract:Aim:Electrodes that provide brain to machine or computer interfacing must survive the lifetime of the person to be considered an acceptable prosthetic. The electrodes may be external such as with electroencephalographic (EEG), internal extracortical such as electrocorticographic (ECoG) or intracortical. Methods:Most i...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.00111

    authors: Gearing M,Kennedy P

    更新日期:2020-04-21 00:00:00

  • Repeating with the right hemisphere: reduced interactions between phonological and lexical-semantic systems in crossed aphasia?

    abstract::Knowledge on the patterns of repetition amongst individuals who develop language deficits in association with right hemisphere lesions (crossed aphasia) is very limited. Available data indicate that repetition in some crossed aphasics experiencing phonological processing deficits is not heavily influenced by lexical-s...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00675

    authors: De-Torres I,Dávila G,Berthier ML,Walsh SF,Moreno-Torres I,Ruiz-Cruces R

    更新日期:2013-10-18 00:00:00

  • Auditory grouping mechanisms reflect a sound's relative position in a sequence.

    abstract::The human brain uses acoustic cues to decompose complex auditory scenes into its components. For instance to improve communication, a listener can select an individual "stream," such as a talker in a crowded room, based on cues such as pitch or location. Despite numerous investigations into auditory streaming, few hav...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00158

    authors: Hill KT,Bishop CW,Miller LM

    更新日期:2012-06-08 00:00:00

  • The Differential Effect of Arm Movements during Gait on the Forward Acceleration of the Centre of Mass in Children with Cerebral Palsy and Typically Developing Children.

    abstract::Background: We aimed to study the contribution of upper limb movements to propulsion during walking in typically developing (TD) children (n = 5) and children with hemiplegic and diplegic cerebral palsy (CP; n = 5 and n = 4, respectively). Methods: Using integrated three-dimensional motion capture data and a scaled ge...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00096

    authors: Meyns P,Molenaers G,Duysens J,Jonkers I

    更新日期:2017-03-01 00:00:00

  • The Saccadic Re-Centering Bias is Associated with Activity Changes in the Human Superior Colliculus.

    abstract::Being able to effectively explore our visual world is of fundamental importance, and it has been suggested that the straight-ahead gaze (primary position) might play a special role in this context. We employed fMRI in humans to investigate how neural activity might be modulated for saccades relative to this putative d...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00193

    authors: Krebs RM,Schoenfeld MA,Boehler CN,Song AW,Woldorff MG

    更新日期:2010-11-01 00:00:00

  • Real World Problem-Solving.

    abstract::Real world problem-solving (RWPS) is what we do every day. It requires flexibility, resilience, resourcefulness, and a certain degree of creativity. A crucial feature of RWPS is that it involves continuous interaction with the environment during the problem-solving process. In this process, the environment can be seen...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00261

    authors: Sarathy V

    更新日期:2018-06-26 00:00:00

  • The neural signature of the Fraser illusion: an explorative EEG study on Fraser-like displays.

    abstract::We studied neural correlates accompanying the Fraser spiral illusion. The Fraser spiral illusion consists of twisted cords superimposed on a patchwork background arranged in concentric circles, which is typically perceived as a spiral. We tested four displays: the Fraser spiral illusion and three variants derived from...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00374

    authors: Yun X,Hazenberg SJ,Jacobs RH,Qiu J,van Lier R

    更新日期:2015-07-02 00:00:00

  • Examining neural correlates of skill acquisition in a complex videogame training program.

    abstract::Acquisition of complex skills is a universal feature of human behavior that has been conceptualized as a process that starts with intense resource dependency, requires effortful cognitive control, and ends in relative automaticity on the multi-faceted task. The present study examined the effects of different theoretic...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00115

    authors: Prakash RS,De Leon AA,Mourany L,Lee H,Voss MW,Boot WR,Basak C,Fabiani M,Gratton G,Kramer AF

    更新日期:2012-05-15 00:00:00

  • Unimodal and multimodal regions for logographic language processing in left ventral occipitotemporal cortex.

    abstract::The human neocortex appears to contain a dedicated visual word form area (VWFA) and an adjacent multimodal (visual/auditory) area. However, these conclusions are based on functional magnetic resonance imaging (fMRI) of alphabetic language processing, languages that have clear grapheme-to-phoneme correspondence (GPC) r...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00619

    authors: Deng Y,Wu Q,Weng X

    更新日期:2013-09-27 00:00:00

  • Effects of Diazepam on Reaction Times to Stop and Go.

    abstract::Introduction: The ability to stop the execution of a movement in response to an external cue requires intact executive function. The effect of psychotropic drugs on movement inhibition is largely unknown. Movement stopping can be estimated by the Stop Signal Reaction Time (SSRT). In a recent publication, we validated ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.567177

    authors: Sarkar S,Choudhury S,Islam N,Chowdhury MSJH,Chowdhury MTI,Baker MR,Baker SN,Kumar H

    更新日期:2020-10-06 00:00:00

  • What do we gain from gamma? Local dynamic gain modulation drives enhanced efficacy and efficiency of signal transmission.

    abstract::Gamma oscillations in neocortex are hypothesized to improve information transmission between groups of neurons. We recently showed that optogenetic drive of fast-spiking interneurons (FS) at 40 Hz in mouse neocortex in vivo modulates the spike count and precision of sensory evoked responses. At specific phases of alig...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00185

    authors: Knoblich U,Siegle JH,Pritchett DL,Moore CI

    更新日期:2010-10-21 00:00:00

  • Cortical oxygen consumption in mental arithmetic as a function of task difficulty: a near-infrared spectroscopy approach.

    abstract::The present study investigated changes in cortical oxygenation during mental arithmetic using near-infrared spectroscopy (NIRS). Twenty-nine male volunteers were examined using a 52-channel continuous wave system for analyzing activity in prefrontal areas. With the help of a probabilistic mapping method, three regions...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00217

    authors: Verner M,Herrmann MJ,Troche SJ,Roebers CM,Rammsayer TH

    更新日期:2013-05-22 00:00:00

  • Discordant Tasks and Motor Adjustments Affect Interactions between Adaptations to Altered Kinematics and Dynamics.

    abstract::Motor control and adaptation are multi-determinate processes with complex interactions. This is reflected for example in the ambiguous nature of interactions during sequential adaptation of reaching under kinematics and dynamics perturbations. It has been suggested that perturbations based on the same kinematic parame...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.065.2009

    authors: Arce F,Novick I,Vaadia E

    更新日期:2010-01-04 00:00:00

  • Performance improvements from imagery: evidence that internal visual imagery is superior to external visual imagery for slalom performance.

    abstract::We report three experiments investigating the hypothesis that use of internal visual imagery (IVI) would be superior to external visual imagery (EVI) for the performance of different slalom-based motor tasks. In Experiment 1, three groups of participants (IVI, EVI, and a control group) performed a driving-simulation s...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00697

    authors: Callow N,Roberts R,Hardy L,Jiang D,Edwards MG

    更新日期:2013-10-21 00:00:00

  • Into the Wild: Neuroergonomic Differentiation of Hand-Held and Augmented Reality Wearable Displays during Outdoor Navigation with Functional Near Infrared Spectroscopy.

    abstract::Highly mobile computing devices promise to improve quality of life, productivity, and performance. Increased situation awareness and reduced mental workload are two potential means by which this can be accomplished. However, it is difficult to measure these concepts in the "wild". We employed ultra-portable battery op...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00216

    authors: McKendrick R,Parasuraman R,Murtza R,Formwalt A,Baccus W,Paczynski M,Ayaz H

    更新日期:2016-05-18 00:00:00

  • Electrocorticographic Activation within Human Auditory Cortex during Dialog-Based Language and Cognitive Testing.

    abstract::Current models of cortical speech and language processing include multiple regions within the temporal lobe of both hemispheres. Human communication, by necessity, involves complex interactions between regions subserving speech and language processing with those involved in more general cognitive functions. To assess ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00202

    authors: Nourski KV,Steinschneider M,Rhone AE

    更新日期:2016-05-04 00:00:00

  • A combined robotic and cognitive training for locomotor rehabilitation: evidences of cerebral functional reorganization in two chronic traumatic brain injured patients.

    abstract::It has been demonstrated that automated locomotor training can improve walking capabilities in spinal cord-injured subjects but its effectiveness on brain damaged patients has not been well established. A possible explanation of the discordant results on the efficacy of robotic training in patients with cerebral lesio...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2011.00146

    authors: Sacco K,Cauda F,D'Agata F,Duca S,Zettin M,Virgilio R,Nascimbeni A,Belforte G,Eula G,Gastaldi L,Appendino S,Geminiani G

    更新日期:2011-11-23 00:00:00

  • Dynamic Reconfiguration of the Supplementary Motor Area Network during Imagined Music Performance.

    abstract::The supplementary motor area (SMA) has been shown to be the center for motor planning and is active during music listening and performance. However, limited data exist on the role of the SMA in music. Music performance requires complex information processing in auditory, visual, spatial, emotional, and motor domains, ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00606

    authors: Tanaka S,Kirino E

    更新日期:2017-12-12 00:00:00