Abstract：
BACKGROUND:To understand the role of ghrelin in the mechanism of action of laparoscopic sleeve gastrectomy (LSG), a prospective cohort case-control study to assess the expression of ghrelin-producing cells (GPC) in two groups of patients was designed. METHODS:Specimens of resected stomach from 26 obese patients who underwent LSG (group A), were compared by immunohistochemistry to control stomach samples from 26 non-obese patients (group B) resected for other pathologies or during autopsy; (GIST: 6 cases, inflammatory diseases: 4 cases, post-mortem autopsy cases with stomachs from healthy persons victims of traumatic accidents: 16 cases). Immunohistochemistry investigation was performed with the use of Ventana Benchmark ultra, anti-ghrelin antibody NOVUS, mouse monoclonal 2F4, diluted at 1:100. RESULTS:No significant difference in the expression of GPC number between group A and B was found (p = 0.87). No significant correlation between patients presenting a GPC number above (subgroup 1) or below (subgroup 2) the average, and EWL% changes, both at 1 and 6 years of follow-up, was recorded. CONCLUSIONS:Our study has shown that the expression of GPC is similar in the stomach of obese and non-obese controls, being mostly influenced by the inflammatory status of the gastric mucosa. A variation in the preoperative number of GPC has not influenced the weight loss in patients who underwent LSG.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Musella M,Di Capua F,D'Armiento M,Velotti N,Bocchetti A,Di Lauro K,Galloro G,Campione S,Petrella G,D'Armiento FPdoi
10.1007/s11695-018-3401-ysubject
Has Abstractpub_date
2018-11-01 00:00:00pages
3604-3610issue
11eissn
0960-8923issn
1708-0428pii
10.1007/s11695-018-3401-yjournal_volume
28pub_type
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