[Evaluation of the safety of different doses of folic acid supplements in women in Brazil].

Abstract:

OBJECTIVE:To evaluate the distribution of folic acid intake and the safety of different doses of supplements in women of childbearing age. METHODS:Data were used from two non-consecutive days of food records of 6,837 women of childbearing age (19-40 years old) participants of the National Food Survey, a module of the Household Budget Survey 2008-2009. Means and percentiles of usual consumption of natural folate and folic acid were estimated using the National Cancer Institute method. Five scenarios were simulated by adding different daily doses of fortification (400 mcg, 500 mcg, 600 mcg, 700 mcg and 800 mcg) to folic acid derived from food consumed by the women. To define a safe dose of the supplement, the total folate (dietary + supplement) was compared with the tolerable upper intake level (UL = 1,000 mcg). RESULTS:Women with usual intake of folic acid above the tolerable upper intake levels were observed only for doses of supplement of 800 mcg (7.0% of women). Below this value, any dose of the supplement was safe. CONCLUSIONS:The use of supplements of up to 700 mcg of folic acid was shown to be safe.

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Santos Qd,Sichieri R,Marchioni DM,Verly E Jr

doi

10.1590/s0034-8910.2013047004769

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

952-7

issue

5

eissn

0034-8910

issn

1518-8787

pii

S0034-89102013000500952

journal_volume

47

pub_type

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