An effect of maternal nifedipine therapy on fetoplacental blood flow: a prospective study.

Abstract:

PURPOSE:The aim of this study is to assess the effects of maternal nifedipine administration on placental and fetal blood flow. METHODS:A total of 29 patients with preterm labor diagnosis admitted to the tertiary care center, Zeynep Kamil Hospital, were evaluated. Before and 24-48 h after administration of oral nifedipine, Doppler ultrasound scan was carried out to measure fetal middle cerebral artery, ductus venosus, umbilical artery, and maternal uterine artery blood flow. RESULTS:After 24 and 48 h of therapy, there were no changes in mean PI and RI in the umbilical arteries and ductus venosus (p > 0.05). Fetal middle cerebral artery and maternal uterine artery PI and RI values showed a significant reduction 24-48 h after oral nifedipine therapy (p < 0.05). CONCLUSIONS:Our study showed that 24 and 48 h after oral nifedipine therapy, there is a significant increase in fetal MCA and maternal uterine artery blood flow, while fetal umbilical artery and ductus venosus Doppler values do not change.

journal_name

Arch Gynecol Obstet

authors

Namazov A,Grin L,Karakus R,Uludogan M,Ayvaci H

doi

10.1007/s00404-018-4839-9

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

685-688

issue

4

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-018-4839-9

journal_volume

298

pub_type

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