Organization out of disorder: liquid-liquid phase separation in plants.

Abstract:

:Membraneless compartments are formed from the dynamic physical association of proteins and RNAs through liquid-liquid phase separation, and have recently emerged as an exciting new mechanism to explain the dynamic organization of biochemical processes in the cell. In this review, we provide an overview of the current knowledge of the process of phase separation in plants and other eukaryotes. We discuss specific examples of liquid-like membraneless compartments found in green plants, their composition, and the intriguing prevalence of proteins with intrinsically disordered domains. Finally, we speculate on the function of disordered proteins in regulating the formation of membraneless compartments and how their conformational flexibility may be important for molecular memory and for sensing perturbations in the physicochemical environment of the cell, particularly important processes in sessile organisms.

journal_name

Curr Opin Plant Biol

authors

Cuevas-Velazquez CL,Dinneny JR

doi

10.1016/j.pbi.2018.05.005

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

68-74

issue

Pt A

eissn

1369-5266

issn

1879-0356

pii

S1369-5266(17)30229-7

journal_volume

45

pub_type

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