Abstract:
PURPOSE:Indomethacin, a nonselective prostaglandin inhibitor used to treat patent ductus arteriosus, is associated with intestinal perforation inducing an NEC-like illness. We sought to define the contribution of prostaglandin E2 (PG E2) and its receptor EP4 to intestinal blood flow regulation in premature neonates with NEC. METHODS:Newborn Sprague-Dawley rats were randomized by litter to undergo experimental NEC induction or to serve as a CONTROL. At 48hours of age, intestinal laser Doppler blood flow was assessed at baseline and after intraperitoneal administration of indomethacin, PG E2, EP4 antagonist, or EP4 agonist. Data were analyzed using a 2-way ANOVA with post hoc Tukey-Kramer correction. RESULTS:At baseline, NEC animals had lower intestinal blood flow than controls. Indomethacin, PG E2 and EP4 agonist all increased ileal blood flow, but PG E2 and EP4 agonist increased blood flow the most in NEC pups. EP4 antagonist decreased intestinal perfusion in both groups. CONCLUSION:The above evidence suggests the importance of PG E2 and EP4 in regulation of neonatal intestinal blood flow. Since indomethacin treatment of patent ductus arteriosus in the premature infant is associated with an increased risk of intestinal perforation owing to compromised blood flow, PG E2 supplementation might provide intestinal protection if administered simultaneously with indomethacin.
journal_name
J Pediatr Surgjournal_title
Journal of pediatric surgeryauthors
K Walker S,Matheson PJ,Galganski LA,Garrison RN,Downard CDdoi
10.1016/j.jpedsurg.2014.01.029subject
Has Abstractpub_date
2014-06-01 00:00:00pages
945-9; discussion 949issue
6eissn
0022-3468issn
1531-5037pii
S0022-3468(14)00038-4journal_volume
49pub_type
杂志文章abstract:BACKGROUND:Minimally invasive surgery has broad applicability to pediatric diseases, including pediatric cancer resection. Neuroblastic tumors of childhood are highly variable in presentation, and so careful selection of appropriate candidates for minimally invasive resection is paramount to achieving safe and durable ...
journal_title:Journal of pediatric surgery
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abstract:PURPOSE:The treatment of cystic lymphatic malformations of the neck and mediastinum is controversial. Surgical management may be limited by the invasiveness of the procedure, the complex anatomy of this region, and the high recurrence rate. An alternative therapeutic method is sclerotherapy. We report our experience in...
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abstract:PURPOSE:The purpose of this study was to describe morphological classification of congenital buried penis (BP) and present a versatile surgical approach for correction. MATERIALS AND METHODS:Sixty-one patients referred with BP were classified into 3 grades according to morphological findings: Grade 1-29 patients with ...
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abstract::From 1973 to 1988, 105 children with renal failure (average age, 6.5 years; range, 5 days to 16.2 years) were treated with hemodialysis via surgically implanted Scribner shunts (n = 120). The average duration of dialysis was 16 days (range, 1 to 194 days). Twenty-three patients died during treatment or during the hosp...
journal_title:Journal of pediatric surgery
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doi:10.1016/0022-3468(94)90153-8
更新日期:1994-11-01 00:00:00
abstract::MURCS association is rare, first described by Duncan in 1979, including nonrandom association of Mullerian duct aplasia or hypoplasia (MU), renal agenesis or ectopy (R), and cervicothoracic somite dysplasia. A 5-year-old girl was admitted to the clinic with a complaint of anteriorly located anus. Physical and radiolog...
journal_title:Journal of pediatric surgery
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abstract:PURPOSE:A fecalith is a fecal concretion that can obstruct the appendix leading to acute appendicitis. We hypothesized that the presence of a fecalith would lead to an earlier appendiceal perforation. METHODS:Between January 2001 and December 2005, the charts of all patients younger than 18 years old who underwent app...
journal_title:Journal of pediatric surgery
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doi:10.1016/j.jpedsurg.2007.12.034
更新日期:2008-05-01 00:00:00
abstract::We here report the clinical findings and management of 9 consecutive cases of chylothorax, 5 of which occurred spontaneously. One cases followed cardiac surgery. Three cases occurred in low-birth-weight, premature infants concurrently with other symptoms of the superior vena cava syndrome secondary to central intraven...
journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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doi:10.1016/0022-3468(76)90170-6
更新日期:1976-02-01 00:00:00
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journal_title:Journal of pediatric surgery
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doi:10.1016/j.jpedsurg.2005.08.035
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journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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doi:10.1016/j.jpedsurg.2017.01.048
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abstract::Stomal prolapse is a common complication of colostomies and, if severe, may affect the timing of the definitive procedure. A simple technique for postreduction bowel fixation without stomal revision is presented. The reduced bowel is attached to the parietal peritoneum using a "U" type suture a few centimeters from th...
journal_title:Journal of pediatric surgery
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doi:10.1016/s0022-3468(85)80017-8
更新日期:1985-12-01 00:00:00
abstract::A 21-year-old female underwent a Kasai hepatoportoenterostomy with Roux-en-Y reconstruction for typeIII biliary atresia at age 63 days. At the age of 19 years, she developed cholangitis and CT scan revealed hepatolithiasis. She presented for treatment of the intrahepatic stone and the hepatportoenterostomy was directl...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.jpedsurg.2016.06.019
更新日期:2016-09-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1053/jpsu.2003.50001
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/PURPOSE:The aim of this study was to establish a prenatal prognostic classification system for risk-stratified management in fetuses with isolated congenital diaphragmatic hernia (CDH). METHODS:A multi-institutional retrospective cohort study of isolated CDH, diagnosed prenatally in fetuses delivered during...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jpedsurg.2011.06.007
更新日期:2011-10-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(96)90684-3
更新日期:1996-05-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(98)90604-2
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:Prenatal risk assessment of congenital diaphragmatic hernia (CDH) relies on prenatal ultrasound (U/S) and fetal magnetic resonance imaging (MRI). When the modalities differ in prognosis, it is unclear which is more reliable. METHODS:Retrospective chart review identified cases of prenatally diagnosed CDH from 4...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.jpedsurg.2019.11.007
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abstract::Breath hydrogen levels were investigated prospectively from birth, in a population of neonates at risk of developing NEC. This was standardized to the quantity of carbohydrate in the feed. Children who developed NEC, confirmed radiologically, were compared with matched controls. There was a significant increase in bre...
journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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doi:10.1016/s0022-3468(89)80262-3
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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更新日期:1980-08-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(83)80044-x
更新日期:1983-12-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(86)80642-x
更新日期:1986-01-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(88)80018-6
更新日期:1988-11-01 00:00:00
abstract::Nine infants underwent operations for perforation of a Meckel's diverticulum over a 21-yr period. All of the infants were acutely ill when initially seen by the surgical service. Lethargy, irritability, anorexia, fever, abdominal tenderness, and passage of blood in the stools were common clinical manifestations. The p...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/0022-3468(75)90277-8
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND/PURPOSE:Our approach to full-thickness anorectal prolapse has transitioned to laparoscopic suture rectopexy (LSRP). The purpose of this study was to describe the indications, technique, and postoperative outcomes for LSRP. METHODS:Rectopexy was performed using 3 or 4 laparoscopic ports. Redundant rectum was...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.jpedsurg.2010.06.006
更新日期:2010-10-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(98)90381-5
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Prenatal diagnosis and outcome of right congenital diaphragmatic hernia (RCDH) are far less well known than the more common left CDH (LCDH). In addition, onset of RCDH beyond the neonatal period with a spectrum of atypical symptoms is not unusual. A retrospective analysis of RCDH treated at a single center o...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.jpedsurg.2006.10.044
更新日期:2007-03-01 00:00:00