Towards a unified theory of health-disease: II. Holopathogenesis.

Abstract:

:This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Almeida Filho N

doi

10.1590/s0034-8910.2014048005196

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

192-205

issue

2

eissn

0034-8910

issn

1518-8787

pii

S0034-89102014000200192

journal_volume

48

pub_type

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