Abstract:
:The role of oral antibiotic prophylaxis and mechanical bowel preparation in colorectal surgery remains controversial. The lack of efficacy of mechanical preparation to improve infection rates, its adverse effects, and multimodal rehabilitation programs have led to a decline in its use. This review aims to evaluate current evidence on antegrade colonic cleansing combined with oral antibiotics for the prevention of surgical site infections. In experimental studies, oral antibiotics decrease the bacterial inoculum, both in the bowel lumen and surgical field. Clinical studies have shown a reduction in infection rates when oral antibiotic prophylaxis is combined with mechanical preparation. Oral antibiotics alone seem to be effective in reducing infection in observational studies, but their effect is inferior to the combined preparation. In conclusion, the combination of oral antibiotics and mechanical preparation should be considered the gold standard for the prophylaxis of postoperative infections in colorectal surgery.
journal_name
Cir Espjournal_title
Cirugia espanolaauthors
Badia JM,Arroyo-García Ndoi
10.1016/j.ciresp.2018.03.009subject
Has Abstractpub_date
2018-01-01 00:00:00pages
317-325issue
6eissn
0009-739Xissn
1578-147Xpii
S0009-739X(18)30121-0journal_volume
96pub_type
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