Abstract：
INTRODUCTION:The aim of this study was to analyze prognostic factors for survival and recurrence in patients with resected pancreatic neuroendocrine tumors (PNT). METHODS:Medical records of 95 patients with resected PNT were retrospectively reviewed. The variables studied were: age, sex, form of presentation (sporadic/familial tumors), functionality, type of tumor, localization, type of surgery, tumor size, multifocal tumors and recurrent rate. The new WHO classification (2010) was used. RESULTS:There were 45 men and 50 women. Mean age was 46.8 years. Regarding the mode of presentation, it was sporadic in 66 patients (69.8%) and 29 cases were familial neuroendocrine tumors (30.2%) in association with MEN 1 syndrome. The 59% of patients suffered from non-functional tumors and 41% were functional: 20 insulinoma, 16 gastrinoma, and 3 glucagonoma. Distal pancreatectomy was the most common surgical procedure, followed by tumor enucleation in 19 patients. According to the WHO classification, 59 patients had a PNT G1, 24 PNT G2 and 12 with a poorly-differentiated carcinoma, respectively. The 5-year survival in well-differentiated tumors was 100%, regardless of the functionality. Sporadic PNT are more commonly unifocal (P<0.001), associating liver metastasis. Survival and recurrence rates after a mean follow-up of 85.3 months were 65.8 and 24%, respectively. CONCLUSIONS:In our experience, WHO classification was an independent prognostic factor in PNT survival.
journal_name
Cir Espjournal_title
Cirugia espanolaauthors
Sánchez-Bueno F,Rodríguez González JM,Torres Salmerón G,Bernabé Peñalver A,Balsalobre Salmeron M,de la Peña Moral J,Fuster Quiñonero M,Parrilla Paricio Pdoi
10.1016/j.ciresp.2016.05.010subject
Has Abstractpub_date
2016-10-01 00:00:00pages
473-80issue
8eissn
0009-739Xissn
1578-147Xpii
S0009-739X(16)30057-4journal_volume
94pub_type
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