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Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

Abstract：

BACKGROUND:Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. OBJECTIVE:We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY. METHODS:We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM10), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants' monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR. RESULTS:Increased PM10 was associated with mLOY, namely decreased mLRR (p-trend = 0.03). Compared with the lowest tertile (≤28.5 μg/m3), the middle (28.5-31.0 μg/m3; β = -0.0044, p = 0.09) and highest (≥31 μg/m3; β = -0.0054, p = 0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (β = -0.00035, p = 0.06) and smoking pack-years (β = -0.00011, p = 1.4E-3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants. CONCLUSIONS:PM10 may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.

journal_name

Environ Int

journal_title

Environment international

authors

Wong JYY,Margolis HG,Machiela M,Zhou W,Odden MC,Psaty BM,Robbins J,Jones RR,Rotter JI,Chanock SJ,Rothman N,Lan Q,Lee JS

doi

10.1016/j.envint.2018.04.030

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

239-247

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(17)32118-9

journal_volume

116

pub_type

杂志文章

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