Methods for Assessment of Memory Reactivation.

Abstract:

:It has been suggested that reactivation of previously acquired experiences or stored information in declarative memories in the hippocampus and neocortex contributes to memory consolidation and learning. Understanding memory consolidation depends crucially on the development of robust statistical methods for assessing memory reactivation. To date, several statistical methods have seen established for assessing memory reactivation based on bursts of ensemble neural spike activity during offline states. Using population-decoding methods, we propose a new statistical metric, the weighted distance correlation, to assess hippocampal memory reactivation (i.e., spatial memory replay) during quiet wakefulness and slow-wave sleep. The new metric can be combined with an unsupervised population decoding analysis, which is invariant to latent state labeling and allows us to detect statistical dependency beyond linearity in memory traces. We validate the new metric using two rat hippocampal recordings in spatial navigation tasks. Our proposed analysis framework may have a broader impact on assessing memory reactivations in other brain regions under different behavioral tasks.

journal_name

Neural Comput

journal_title

Neural computation

authors

Liu S,Grosmark AD,Chen Z

doi

10.1162/neco_a_01090

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

2175-2209

issue

8

eissn

0899-7667

issn

1530-888X

journal_volume

30

pub_type

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