Minimal model for intracellular calcium oscillations and electrical bursting in melanotrope cells of Xenopus laevis.

Abstract:

:A minimal model is presented to explain changes in frequency, shape, and amplitude of Ca2+ oscillations in the neuroendocrine melanotrope cell of Xenopus Laevis. It describes the cell as a plasma membrane oscillator with influx of extracellular Ca2+ via voltage-gated Ca2+ channels in the plasma membrane. The Ca2+ oscillations in the Xenopus melanotrope show specific features that cannot be explained by previous models for electrically bursting cells using one set of parameters. The model assumes a KCa-channel with slow Ca2+-dependent gating kinetics that initiates and terminates the bursts. The slow kinetics of this channel cause an activation of the Kca-channel with a phase shift relative to the intracellular Ca2+ concentration. The phase shift, together with the presence of a Na+ channel that has a lower threshold than the Ca2+ channel, generate the characteristic features of the Ca2+ oscillations in the Xenopus melanotrope cell.

journal_name

Neural Comput

journal_title

Neural computation

authors

Cornelisse LN,Scheenen WJ,Koopman WJ,Roubos EW,Gielen SC

doi

10.1162/089976601300014655

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

113-37

issue

1

eissn

0899-7667

issn

1530-888X

journal_volume

13

pub_type

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