Abstract:
:A minimal model is presented to explain changes in frequency, shape, and amplitude of Ca2+ oscillations in the neuroendocrine melanotrope cell of Xenopus Laevis. It describes the cell as a plasma membrane oscillator with influx of extracellular Ca2+ via voltage-gated Ca2+ channels in the plasma membrane. The Ca2+ oscillations in the Xenopus melanotrope show specific features that cannot be explained by previous models for electrically bursting cells using one set of parameters. The model assumes a KCa-channel with slow Ca2+-dependent gating kinetics that initiates and terminates the bursts. The slow kinetics of this channel cause an activation of the Kca-channel with a phase shift relative to the intracellular Ca2+ concentration. The phase shift, together with the presence of a Na+ channel that has a lower threshold than the Ca2+ channel, generate the characteristic features of the Ca2+ oscillations in the Xenopus melanotrope cell.
journal_name
Neural Computjournal_title
Neural computationauthors
Cornelisse LN,Scheenen WJ,Koopman WJ,Roubos EW,Gielen SCdoi
10.1162/089976601300014655subject
Has Abstractpub_date
2001-01-01 00:00:00pages
113-37issue
1eissn
0899-7667issn
1530-888Xjournal_volume
13pub_type
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