Abstract:
:To understand the interspike interval (ISI) variability displayed by visual cortical neurons (Softky & Koch, 1993), it is critical to examine the dynamics of their neuronal integration, as well as the variability in their synaptic input current. Most previous models have focused on the latter factor. We match a simple integrate-and-fire model to the experimentally measured integrative properties of cortical regular spiking cells (McCormick, Connors, Lighthall, & Prince, 1985). After setting RC parameters, the post-spike voltage reset is set to match experimental measurements of neuronal gain (obtained from in vitro plots of firing frequency versus injected current). Examination of the resulting model leads to an intuitive picture of neuronal integration that unifies the seemingly contradictory 1/square root of N and random walk pictures that have previously been proposed. When ISIs are dominated by postspike recovery, 1/square root of N arguments hold and spiking is regular; after the "memory" of the last spike becomes negligible, spike threshold crossing is caused by input variance around a steady state and spiking is Poisson. In integrate-and-fire neurons matched to cortical cell physiology, steady-state behavior is predominant, and ISIs are highly variable at all physiological firing rates and for a wide range of inhibitory and excitatory inputs.
journal_name
Neural Computjournal_title
Neural computationauthors
Troyer TW,Miller KDdoi
10.1162/neco.1997.9.5.971subject
Has Abstractpub_date
1997-07-01 00:00:00pages
971-83issue
5eissn
0899-7667issn
1530-888Xjournal_volume
9pub_type
杂志文章abstract::Real classification problems involve structured data that can be essentially grouped into a relatively small number of clusters. It is shown that, under a local clustering condition, a set of points of a given class, embedded in binary space by a set of randomly parameterized surfaces, is linearly separable from other...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976601753196012
更新日期:2001-11-01 00:00:00
abstract::A necessary ingredient for a quantitative theory of neural coding is appropriate "spike kinematics": a precise description of spike trains. While summarizing experiments by complete spike time collections is clearly inefficient and probably unnecessary, the most common probabilistic model used in neurophysiology, the ...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.2009.07-08-828
更新日期:2009-08-01 00:00:00
abstract::Cortical neurons of behaving animals generate irregular spike sequences. Recently, there has been a heated discussion about the origin of this irregularity. Softky and Koch (1993) pointed out the inability of standard single-neuron models to reproduce the irregularity of the observed spike sequences when the model par...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976699300016511
更新日期:1999-05-15 00:00:00
abstract::The need to reason about uncertainty in large, complex, and multimodal data sets has become increasingly common across modern scientific environments. The ability to transform samples from one distribution journal_title:Neural computation pub_type: 杂志文章 doi:10.1162/neco_a_01172 更新日期:2019-04-01 00:00:00
abstract::Uncertainty coming from the noise in its neurons and the ill-posed nature of many tasks plagues neural computations. Maybe surprisingly, many studies show that the brain manipulates these forms of uncertainty in a probabilistically consistent and normative manner, and there is now a rich theoretical literature on the ...
journal_title:Neural computation
pub_type: 信件
doi:10.1162/neco.2007.19.2.404
更新日期:2007-02-01 00:00:00
abstract::A modular, recurrent connectionist network is taught to incrementally parse complex sentences. From input presented one word at a time, the network learns to do semantic role assignment, noun phrase attachment, and clause structure recognition, for sentences with both active and passive constructions and center-embedd...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.1991.3.1.110
更新日期:1991-04-01 00:00:00
abstract::Synchronized firings in the networks of class 1 excitable neurons with excitatory and inhibitory connections are investigated, and their dependences on the forms of interactions are analyzed. As the forms of interactions, we treat the double exponential coupling and the interactions derived from it: pulse coupling, ex...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/0899766053630387
更新日期:2005-06-01 00:00:00
abstract::Due to many experimental reports of synchronous neural activity in the brain, there is much interest in understanding synchronization in networks of neural oscillators and its potential for computing perceptual organization. Contrary to Hopfield and Herz (1995), we find that networks of locally coupled integrate-and-f...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976699300016160
更新日期:1999-10-01 00:00:00
abstract::We propose that replication (with mutation) of patterns of neuronal activity can occur within the brain using known neurophysiological processes. Thereby evolutionary algorithms implemented by neuro- nal circuits can play a role in cognition. Replication of structured neuronal representations is assumed in several cog...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00031
更新日期:2010-11-01 00:00:00
abstract::Multiple adjacent, roughly mirror-image topographic maps are commonly observed in the sensory neocortex of many species. The cortical regions occupied by these maps are generally believed to be determined initially by genetically controlled chemical markers during development, with thalamocortical afferent activity su...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/0899766053491904
更新日期:2005-05-01 00:00:00
abstract::Volterra and Wiener series are perhaps the best-understood nonlinear system representations in signal processing. Although both approaches have enjoyed a certain popularity in the past, their application has been limited to rather low-dimensional and weakly nonlinear systems due to the exponential growth of the number...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.2006.18.12.3097
更新日期:2006-12-01 00:00:00
abstract::The Hebbian paradigm is perhaps the best-known unsupervised learning theory in connectionism. It has inspired wide research activity in the artificial neural network field because it embodies some interesting properties such as locality and the capability of being applicable to the basic weight-and-sum structure of ne...
journal_title:Neural computation
pub_type: 杂志文章,评审
doi:10.1162/0899766053429381
更新日期:2005-04-01 00:00:00
abstract::In this note, we demonstrate that the high firing irregularity produced by the leaky integrate-and-fire neuron with the partial somatic reset mechanism, which has been shown to be the most likely candidate to reflect the mechanism used in the brain for reproducing the highly irregular cortical neuron firing at high ra...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00090
更新日期:2011-03-01 00:00:00
abstract::We outline a hybrid analog-digital scheme for computing with three important features that enable it to scale to systems of large complexity: First, like digital computation, which uses several one-bit precise logical units to collectively compute a precise answer to a computation, the hybrid scheme uses several moder...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976602320263971
更新日期:2002-09-01 00:00:00
abstract::In a recent paper, Poggio and Girosi (1990) proposed a class of neural networks obtained from the theory of regularization. Regularized networks are capable of approximating arbitrarily well any continuous function on a compactum. In this paper we consider in detail the learning problem for the one-dimensional case. W...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.1995.7.6.1225
更新日期:1995-11-01 00:00:00
abstract::This letter proposes a multichannel source separation technique, the multichannel variational autoencoder (MVAE) method, which uses a conditional VAE (CVAE) to model and estimate the power spectrograms of the sources in a mixture. By training the CVAE using the spectrograms of training examples with source-class label...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco_a_01217
更新日期:2019-09-01 00:00:00
abstract::We study active learning (AL) based on gaussian processes (GPs) for efficiently enumerating all of the local minimum solutions of a black-box function. This problem is challenging because local solutions are characterized by their zero gradient and positive-definite Hessian properties, but those derivatives cannot be ...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco_a_01307
更新日期:2020-10-01 00:00:00
abstract::We derive solutions for the problem of missing and noisy data in nonlinear time&hyphenseries prediction from a probabilistic point of view. We discuss different approximations to the solutions &hyphen in particular, approximations that require either stochastic simulation or the substitution of a single estimate for t...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976698300017728
更新日期:1998-03-23 00:00:00
abstract::Event-driven simulation strategies were proposed recently to simulate integrate-and-fire (IF) type neuronal models. These strategies can lead to computationally efficient algorithms for simulating large-scale networks of neurons; most important, such approaches are more precise than traditional clock-driven numerical ...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco.2006.18.9.2146
更新日期:2006-09-01 00:00:00
abstract::We analyze convergence of the expectation maximization (EM) and variational Bayes EM (VBEM) schemes for parameter estimation in noisy linear models. The analysis shows that both schemes are inefficient in the low-noise limit. The linear model with additive noise includes as special cases independent component analysis...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/0899766054322991
更新日期:2005-09-01 00:00:00
abstract::Binocular fusion takes place over a limited region smaller than one degree of visual angle (Panum's fusional area), which is on the order of the range of preferred disparities measured in populations of disparity-tuned neurons in the visual cortex. However, the actual range of binocular disparities encountered in natu...
journal_title:Neural computation
pub_type: 信件
doi:10.1162/neco.2008.05-07-532
更新日期:2008-10-01 00:00:00
abstract::We propose a scalable semiparametric Bayesian model to capture dependencies among multiple neurons by detecting their cofiring (possibly with some lag time) patterns over time. After discretizing time so there is at most one spike at each interval, the resulting sequence of 1s (spike) and 0s (silence) for each neuron ...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00631
更新日期:2014-09-01 00:00:00
abstract::We study the learning of an external signal by a neural network and the time to forget it when this network is submitted to noise. The presentation of an external stimulus to the recurrent network of binary neurons may change the state of the synapses. Multiple presentations of a unique signal lead to its learning. Th...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/neco_a_01286
更新日期:2020-07-01 00:00:00
abstract::Calculation of the total conductance change induced by multiple synapses at a given membrane compartment remains one of the most time-consuming processes in biophysically realistic neural network simulations. Here we show that this calculation can be achieved in a highly efficient way even for multiply converging syna...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976698300017061
更新日期:1998-10-01 00:00:00
abstract::Controlling for multiple hypothesis tests using standard spike resampling techniques often requires prohibitive amounts of computation. Importance sampling techniques can be used to accelerate the computation. The general theory is presented, along with specific examples for testing differences across conditions using...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00399
更新日期:2013-02-01 00:00:00
abstract::The instantaneous phase of neural rhythms is important to many neuroscience-related studies. In this letter, we show that the statistical sampling properties of three instantaneous phase estimators commonly employed to analyze neuroscience data share common features, allowing an analytical investigation into their beh...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00422
更新日期:2013-04-01 00:00:00
abstract::We consider learning a causal ordering of variables in a linear nongaussian acyclic model called LiNGAM. Several methods have been shown to consistently estimate a causal ordering assuming that all the model assumptions are correct. But the estimation results could be distorted if some assumptions are violated. In thi...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00533
更新日期:2014-01-01 00:00:00
abstract::In learning theory, the training and test sets are assumed to be drawn from the same probability distribution. This assumption is also followed in practical situations, where matching the training and test distributions is considered desirable. Contrary to conventional wisdom, we show that mismatched training and test...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/NECO_a_00697
更新日期:2015-02-01 00:00:00
abstract::We explicitly analyze the trajectories of learning near singularities in hierarchical networks, such as multilayer perceptrons and radial basis function networks, which include permutation symmetry of hidden nodes, and show their general properties. Such symmetry induces singularities in their parameter space, where t...
journal_title:Neural computation
pub_type: 信件
doi:10.1162/neco.2007.12-06-414
更新日期:2008-03-01 00:00:00
abstract::Neuroscience is progressing vigorously, and knowledge at different levels of description is rapidly accumulating. To establish relationships between results found at these different levels is one of the central challenges. In this simulation study, we demonstrate how microscopic cellular properties, taking the example...
journal_title:Neural computation
pub_type: 杂志文章
doi:10.1162/089976699300016377
更新日期:1999-07-01 00:00:00