How does pharmacogenetic testing alter the treatment course and patient response for chronic-pain patients in comparison with the current "trial-and-error" standard of care?

Abstract:

PURPOSE:To evaluate if pharmacogenetic testing (PT) holds value for pain-management practitioners by identifying the potential applications of pharmacogenetic research as well as applications in practice. DATA SOURCES:A review of the literature was conducted utilizing the databases EBSCOhost, Biomedical Reference Collection, CINAHL, Health Business: Full Text, Health Source: Nursing/Academic Edition, and MEDLINE with the keywords, personalized medicine, cytochrome P450, and phamacogenetics. CONCLUSIONS:Chronic-pain patients present some of the most challenging patients to manage medically. Often paired with persistent, life-altering pain, they might also have oncologic and psychological comorbidities that can further complicate their management. One-step in-office PT is now widely available to optimize management of complicated patients and affectively remove the "trial-and-error" process of medication therapy. IMPLICATIONS FOR PRACTICE:Practitioners must be familiar with the genetic determinants that affect a patient's response to medications in order to decrease preventable morbidity and mortality associated with drug-drug and patient-drug interactions, and to provide cost-effective care through avoidance of inappropriate medications. Improved pain managements will impove patient outcomes and satisfaction.

journal_name

J Am Assoc Nurse Pract

authors

DeFeo K,Sykora K,Eley S,Vincent D

doi

10.1002/2327-6924.12154

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

530-6

issue

10

eissn

2327-6886

issn

2327-6924

journal_volume

26

pub_type

杂志文章
  • Attitudes toward evidence-based clinical decision support tools to reduce exposure to ionizing radiation: The Canadian CT Head Rule.

    abstract:BACKGROUND AND PURPOSE:A large degree of variation in clinical practice exists among clinicians evaluating and treating individuals with minor head injuries. Noncontrast head computerized tomography (CT) scans are commonly used to assess for intracranial damage in patients presenting with head injury. This practice is ...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12402

    authors: Zakhari R,Sterrett SE

    更新日期:2016-12-01 00:00:00

  • Mast cell activation syndrome.

    abstract::Mast cell activation syndrome (MCAS) is a systemic autoinflammatory disease in which mast cells behave erratically. It is unknown whether MCAS recently evolved or if it has been an unrecognized entity for years. Clinically, the patient may present in a constant to near-constant state of allergic reaction. However, the...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000396

    authors: Vacheron N,McClinton T,Lynch-Smith DJ,Umberger R

    更新日期:2020-04-08 00:00:00

  • An integrative review of nurse practitioner education models: Part three of a four-part series on critical topics identified by the 2015 Nurse Practitioner Research Agenda.

    abstract:BACKGROUND AND PURPOSE:Critical research topics were identified after nurse practitioner (NP) organization stakeholders participated in the Fellows of the American Association of Nurse Practitioner, 2015 Nurse Practitioner Research Agenda Roundtable. Strategies and recommendations were identified to support further wor...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章,评审

    doi:10.1097/JXX.0000000000000150

    authors: Kostas-Polston EA,Rawlett K,Miedema J,Dickins K

    更新日期:2018-12-01 00:00:00

  • Research methods for graduate students: a practical framework to guide teachers and learners.

    abstract:PURPOSE:The purpose of this article is to present the Arrow Framework for Research Design, an organizing framework that facilitates teaching and learning of research methods, providing logical organization of interrelationships between concepts, content, and context of research methods, and practice application. The Ar...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12080

    authors: Pearce PF,Christian BJ,Smith SL,Vance DE

    更新日期:2014-01-01 00:00:00

  • Leveraging health care reform to accelerate nurse practitioner full practice authority.

    abstract:BACKGROUND AND PURPOSE:Since development of the nurse practitioner (NP) role, NPs have been advocating for policy allowing them to practice to the full extent of their training. The aim of this research was to determine whether passage of the Affordable Care Act (ACA) had an impact on expansion of NPs' scope of practic...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000023

    authors: Brom HM,Salsberry PJ,Graham MC

    更新日期:2018-03-01 00:00:00

  • Rural parent behaviors and expectations when caring for children with acute respiratory infections.

    abstract:PURPOSE:To explore rural parents' behaviors and expectations regarding acute respiratory infections (ARIs) in children. DATA SOURCES:A random digit dial telephone survey administered to 655 rural adults; 176 answered questions regarding care of their children. CONCLUSIONS:Increasing fluid intake was the action most p...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1111/j.1745-7599.2012.00802.x

    authors: Hart AM,Morgan KM,Casper GM

    更新日期:2013-08-01 00:00:00

  • Characteristics of nurse practitioners and physician assistants in the United States.

    abstract:BACKGROUND:Nurse practitioners (NP) and physician assistants (PA) serve as independent or semiautonomous providers and as fundamental members of healthcare teams. PURPOSE:Differentiating roles of health professionals is needed for optimal employment utilization. Clinically practicing PAs and NPs were characterized. M...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12293

    authors: Hooker RS,Brock DM,Cook ML

    更新日期:2016-01-01 00:00:00

  • Substantiating the need for primary care-based sexual health promotion interventions for ethnic minority adolescent women experiencing health disparities.

    abstract:PURPOSE:Assess the context of psychological distress, violence, and substance use among African- and Mexican-American adolescent women with a history of STI, violence, or high sexual risk behavior. These adolescents experience multiple health disparities, limited access to care, and are at particularly high risk of adv...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12346

    authors: Champion JD,Young C,Rew L

    更新日期:2016-09-01 00:00:00

  • Recognizing the clinical manifestations of acromegaly: case studies.

    abstract:PURPOSE:To present case studies of a 36-year-old woman and a 73-year-old man who presented with the syndrome of acromegaly, and to provide primary care nurse practitioners (NPs) with the understanding of the clinical and laboratory features needed for early recognition and treatment of this fascinating disease. DATA S...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12076

    authors: Iuliano SL,Laws ER Jr

    更新日期:2014-03-01 00:00:00

  • Improving diabetes outcomes by an innovative group visit model: a pilot study.

    abstract:PURPOSE:To develop a group visit model that improves A1C, blood pressure, lipids, depression, and satisfaction among patients with diabetes that can be used in primary care practice settings. DATA SOURCES:Using a pre/post-test descriptive design, data were collected from 22 adult patients of a private family practice ...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1745-7599.2012.00796.x

    authors: Riley SB

    更新日期:2013-09-01 00:00:00

  • MedManage: The development of a tool to assist medication reconciliation in a rural primary care clinic.

    abstract:BACKGROUND:Medication reconciliation is a critical step in the health care process to prevent hospital readmission, adverse drug events, and fall prevention. The purpose of the study was to pilot test a medication reconciliation process, MedManage, informed by the Medications at Transitions and Clinical Handoffs (MATCH...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000197

    authors: Jarrett T,Cochran J,Baus A,Delmar K

    更新日期:2019-12-01 00:00:00

  • Unmet needs in the acute treatment of migraine attacks and the emerging role of calcitonin gene-related peptide receptor antagonists: An integrative review.

    abstract:BACKGROUND:Migraine is a prevalent and chronic disease associated with high rates of disability and significant financial and socioeconomic burden. Current acute treatments for migraine attacks include both migraine-specific (e.g., triptans, ergotamines) and nonspecific (e.g., nonsteroidal anti-inflammatory drugs) medi...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000397

    authors: Mallick-Searle T,Moriarty M

    更新日期:2020-04-16 00:00:00

  • Geographical mapping of advanced practice registered nurses in Louisiana: Leveraging the power of data display.

    abstract:BACKGROUND AND PURPOSE:Identifying the locations of advanced practice registered nurses (APRNs) in the state is challenging without data readily available, which can adversely affect stakeholder initiatives. The purpose of this project was to develop an online interactive map reflecting distribution of APRNs licensed b...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000091

    authors: Becnel BJ,Pearce PF,Eiswirth E

    更新日期:2019-01-01 00:00:00

  • Implementation of a virtual patient-centered weight loss maintenance behavior competency assessment in adults with obesity.

    abstract:BACKGROUND:Evidence shows that 95%-98% of individuals who undergo a diet for weight loss purposes will gain back their weight within 5 years. LOCAL PROBLEM:No standardized method exists to assess weight loss maintenance (WLM) behavior competencies in patients who lose weight within a telehealth nutritional counseling ...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000192

    authors: Brunacini K

    更新日期:2019-12-01 00:00:00

  • Effects of an energy balance educational intervention and the COPE cognitive behavioral therapy intervention for Division I U.S. Air Force Academy female athletes.

    abstract:BACKGROUND AND PURPOSE:Female athletes struggle harder than male athletes to lose body fat and maintain a leaner physique. The purpose of this study was to determine the effects of an educational and cognitive behavioral therapy (CBT)-based intervention on knowledge, body composition, anxiety, stress, and nutritional i...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12359

    authors: Buffington BC,Melnyk BM,Morales S,Lords A,Zupan MR

    更新日期:2016-04-01 00:00:00

  • Standardized adult-gerontology acute care nurse practitioner point-of-care ultrasound training: A new perspective in the age of a pandemic.

    abstract::Our health care landscape is rapidly changing. With the aging population and seemingly increasing outbreak of communicable diseases, it is expected that there will be a continued demand for inpatient/critical care providers. The current COVID-19 pandemic provides a glimpse of a health care system in severe provider sh...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000448

    authors: Chen LL

    更新日期:2020-06-01 00:00:00

  • Recognizing obesity as a disease.

    abstract::Obesity is a chronic, progressive, relapsing disease that impairs health and quality of life and shortens lifespan. Genetic and environmental factors contribute to its development and persistence. If left untreated, it worsens and leads to serious health consequences for those affected, as well as their offspring and ...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000482

    authors: Christensen S

    更新日期:2020-07-01 00:00:00

  • Metabolic syndrome: clinical perspective for best practice.

    abstract:PURPOSE:To explore current studies on metabolic syndrome (MetS), including its complex pathophysiology and to describe the unique role of the advanced practice nurse including management and ethical decision making utilizing a case study to exemplify salient points. DATA SOURCES:From original research articles extract...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章,评审

    doi:10.1002/2327-6924.12048

    authors: Olde D,Alpert P,Dalusung-Angosta A

    更新日期:2013-12-01 00:00:00

  • Provider attitudes and practice patterns of obesity management with pharmacotherapy.

    abstract:BACKGROUND AND PURPOSE:More than one third of American adults are obese. Extreme obesity is rapidly rising. Nine medications are approved for weight loss yet they remain underutilized with the focus primarily on lifestyle modifications. The objective was to determine current prescribing patterns and attitudes of weight...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12481

    authors: Granara B,Laurent J

    更新日期:2017-09-01 00:00:00

  • Precepting nurse practitioner students: A new view-Results of two national surveys of nurse practitioner preceptors.

    abstract:PURPOSE:The aim of two national studies was to identify characteristics of nurse practitioners (NPs) who precept and the benefits, incentives, and barriers associated with the NP preceptor role. METHODS:Stratified randomized sampling was used to invite a representative number of NPs from each state to participate in a...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12482

    authors: Roberts ME,Wheeler KJ,Tyler DO,Padden DL

    更新日期:2017-08-01 00:00:00

  • Autonomy of nurse practitioners in primary care: An integrative review.

    abstract:PURPOSE:This integrative review of the existing literature was conducted to identify dimensions related to nurse practitioner (NP) autonomy and to recommend future areas of research related to the important topic of NP autonomy in this era of cost-conscious healthcare reform. DATA SOURCES:Articles were identified from...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章,评审

    doi:10.1002/2327-6924.12288

    authors: Choi M,De Gagne JC

    更新日期:2016-03-01 00:00:00

  • Evolving role of pediatric nurse practitioners.

    abstract:PURPOSE:To report and interpret findings from national pediatric nurse practitioner (PNP) job analysis surveys reflecting the changes in the knowledge and skills required for advanced practice. DATA SOURCES:National role delineation studies (RDS) conducted by American Nurses Credentialing Center (ANCC) in 2003, 2008, ...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12289

    authors: Aruda MM,Griffin VJ,Schartz K,Geist M

    更新日期:2016-02-01 00:00:00

  • Intent of health care providers to adopt a clinical decision support tool in the management of minor pediatric head injuries.

    abstract:BACKGROUND:Radiographic neuroimaging in minor pediatric head injuries contains risks of radiation-induced malignancy. The Pediatric Emergency Care Applied Research Network (PECARN) head injury protocol identifies head-injured children who are at very low risk of clinically important traumatic brain injuries and can saf...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000208

    authors: Zarchi TB

    更新日期:2020-02-01 00:00:00

  • Nurse practitioners and intent to retire.

    abstract:BACKGROUND AND PURPOSE:Demand for primary care services is rising. Nurse practitioners (NPs) serve vital roles in meeting primary care demands. Workforce planning requires understanding NP retirement intentions. This study examines factors that relate to NPs, aged 55 years and older, and their intent to retire within 5...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12406

    authors: Falk NL,Rudner N,Chapa D,Greene J

    更新日期:2017-03-01 00:00:00

  • Key considerations for moving to a nurse faculty role: A dean's perspective.

    abstract::Expert nurse practitioners (NPs) grounded in clinical practice are needed to prepare the future NPs. This article discusses key considerations for moving from the role of expert clinician to nurse educator. The considerations for making the move to the educator role including reflection on rewards associated with teac...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12489

    authors: Marfell J,Mc Mullen PC,Onieal ME,Scheibmeir M,Hawkins-Walsh E

    更新日期:2017-08-01 00:00:00

  • Positive precepting: Identifying NP student learning levels and needs.

    abstract:BACKGROUND AND PURPOSE:Clinical preceptors are vital partners in the education of nurse practitioner (NP) students. This article describes NP student learning stages and proposes strategies preceptors can use to facilitate precepting NP students who enter clinical rotations at varied learner levels. METHODS:Searches w...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章,评审

    doi:10.1097/JXX.0000000000000106

    authors: Pearson T,Hensley T

    更新日期:2019-02-01 00:00:00

  • Focus group testing of a mobile app for pharmacogenetic-guided dosing.

    abstract:BACKGROUND:A common barrier to implementation of precision medicine is the lack of use of published clinical practice guidelines. Consequently, a user-friendly mechanism to easily adopt these guidelines is imperative. PURPOSE:The purpose of this study was to evaluate the perceptions of a prototype of a clinical decisi...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000392

    authors: Dodson CH,Baker E

    更新日期:2020-02-04 00:00:00

  • Measuring the influence of a mental health training module on the therapeutic optimism of advanced nurse practitioner students in the United Kingdom.

    abstract:PURPOSE:To evaluate the influence of a mental health training module on the therapeutic optimism of advanced nurse practitioner (ANP) students in primary care (family practice). DATA SOURCES:Three cohorts of ANPs who undertook a Mental Health Problems in Primary Care Module as part of their MSc ANP (primary care) run ...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1002/2327-6924.12028

    authors: Hemingway S,Rogers M,Elsom S

    更新日期:2014-03-01 00:00:00

  • Malabsorption anemia and iron supplement induced constipation in post-Roux-en-Y gastric bypass (RYGB) patients.

    abstract:PURPOSE:Over 250,000 bariatric surgical procedures for the management of morbid obesity are performed in the United States annually. The Roux-en-Y gastric bypass (RYGB) is an effective bariatric procedure because of its efficacy in achieving significant weight loss, low complication rates, and outcomes in reducing card...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章,评审

    doi:10.1002/2327-6924.12079

    authors: Sahebzamani FM,Berarducci A,Murr MM

    更新日期:2013-12-01 00:00:00

  • Screening, brief intervention, and referral to treatment training for family nurse practitioner students.

    abstract::Alcohol and substance-related disorders affect individuals throughout the global community. It is important that nurse practitioners understand the use of screening, brief intervention, and referral to treatment (SBIRT) in recognizing these disorders before development of chronic disease conditions. The SBIRT curricul...

    journal_title:Journal of the American Association of Nurse Practitioners

    pub_type: 杂志文章

    doi:10.1097/JXX.0000000000000423

    authors: Arends R,Anderson Elverson C,Pike Keefner T,Mylant M

    更新日期:2020-05-21 00:00:00