Abstract:
OBJECTIVE:A collapsible upper airway is a common cause of obstructive sleep apnea. The exact pathophysiology leading to a more collapsible airway is not well understood. A progressive neuropathy of the soft palate and pharyngeal dilators may be associated with the progression of snoring to OSA. The purpose of this study is to systematically review the international literature investigating the neurophysiologic changes in the soft palate and uvula that contribute to progression from snoring to OSA. METHODS:PubMed/MEDLINE and 4 other databases were systematically searched through July 4, 2017. Eligibility: (1) Patients: controls, snoring or OSA patients (2) Intervention: neuromuscular evaluation of the palate and/or uvula (3) Comparison: differences between controls, snoring and OSA patients (4) Outcomes: neuromuscular outcomes (5) Study design: Peer reviewed publications of any design. RESULTS:845 studies were screened, 76 were downloaded in full text form and thirty-one studies met criteria. Histological studies of the soft palate demonstrated diffuse inflammatory changes, muscular changes consistent with neuropathy, and neural aberrancies. Sensory testing studies provided heterogeneous outcomes though the majority favored neuronal dysfunction. Studies have consistently demonstrated that increasing severity of snoring and sleep apnea is associated with worsening sensory nerve function of the palate in association with atrophic histological changes to the nerves and muscle fibers of the soft palate and uvula. CONCLUSIONS:Recent evidence highlighted in this systematic review implicates the role of neurogenic pathology underlying the loss of soft palate and/or uvular tone in the progression of snoring to sleep apnea.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Patel JA,Ray BJ,Fernandez-Salvador C,Gouveia C,Zaghi S,Camacho Mdoi
10.1016/j.amjoto.2018.03.006subject
Has Abstractpub_date
2018-01-01 00:00:00pages
327-337issue
3eissn
0196-0709issn
1532-818Xpii
S0196-0709(18)30011-5journal_volume
39pub_type
杂志文章,评审abstract:PURPOSE:Due to the COVID-19 pandemic, aerosol-generating procedures (AGPs) such as flexible endoscopic evaluation of swallowing (FEES) have been deemed high-risk and in some cases restricted, indicating the need for additional personal protective equipment. The aim of this study was to erect and study a protective barr...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102888
更新日期:2021-01-04 00:00:00
abstract:OBJECTIVES:To explore surgical timing of facial paralysis after temporal bone trauma. METHODS:The clinical data of the patients with facial paralysis after temporal bone trauma who underwent subtotal facial nerve decompression were retrospectively collected, and 80 cases followed-up for one year were enrolled in the s...
journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2017.01.002
更新日期:2017-01-01 00:00:00
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journal_title:American journal of otolaryngology
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journal_title:American journal of otolaryngology
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doi:10.1053/ajot.2000.18871
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journal_title:American journal of otolaryngology
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doi:10.1016/j.amjoto.2003.10.003
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2009.02.012
更新日期:2010-07-01 00:00:00
abstract::The characteristics of response of 98 vestibular nuclei neurons were investigated in the barbiturate anesthetized cat. All type I and type II neurons (tonic and kinetic) responded to stimulation of the horizontal canals with step and impulse accelerations. Seventy-seven (79 per cent) neurons of all types demonstrated ...
journal_title:American journal of otolaryngology
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journal_title:American journal of otolaryngology
pub_type: 杂志文章,随机对照试验
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2008.05.003
更新日期:2009-07-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/0196-0709(92)90075-5
更新日期:1992-11-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/0196-0709(94)90085-x
更新日期:1994-11-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2020.102444
更新日期:2020-01-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2015.05.003
更新日期:2015-09-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章,随机对照试验
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更新日期:2020-01-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
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更新日期:1995-05-01 00:00:00
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journal_title:American journal of otolaryngology
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更新日期:1985-09-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
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更新日期:1999-11-01 00:00:00
abstract::Meniere's disease is a peripheral audiovestibular disorder characterized by vertigo, hearing loss, tinnitus, and aural fullness. Management of these symptoms includes medical and surgical treatment. Many patients with Meniere's disease can be managed using nonablative therapy, such as intratympanic steroids and endoly...
journal_title:American journal of otolaryngology
pub_type: 杂志文章,评审
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更新日期:2021-01-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2017.12.003
更新日期:2018-01-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
doi:10.1016/j.amjoto.2006.12.006
更新日期:2008-01-01 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
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更新日期:2021-01-05 00:00:00
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journal_title:American journal of otolaryngology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00