Peritoneal reaction resulting from iodinated contrast material: comparative study.

Abstract:

:A consensus does not exist as to the optimal contrast agent for hysterosalpingography. This study was undertaken to evaluate the early and delayed inflammatory responses of the peritoneal surfaces to various types of iodinated contrast media. Guinea pigs received intraperitoneal injections of lactated Ringer solution, iothalamate meglumine, diatrizoate sodium, ioxilan, or ethiodized oil. The inflammatory response of the peritoneal surfaces was assessed at 1,7, and 30 days. Five animals were studied at each time point for each agent. No animals that received Ringer lactate or iothalamate meglumine had inflammation at any time. Ioxilan produced inflammation in two of five animals at 7 days and no inflammation at 1 or 30 days. Ethiodized oil produced no inflammation at 1 day; however, three animals had inflammation at 7 days, and all five had inflammation at 30 days. The 30-day group showed striking inflammatory response with granulomatous features. The authors recommend the continued use of meglumine-based water-soluble ionic contrast material for hysterosalpingography.

journal_name

Radiology

journal_title

Radiology

authors

Eisenberg AD,Winfield AC,Page DL,Holburn GE,Schifter T,Segars JH

doi

10.1148/radiology.172.1.2544920

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

149-51

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

172

pub_type

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