Abstract：
:DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in development, genomic imprinting, X inactivation, chromosome stability, gene expression and methylation aberrations are involved in an array of human diseases. Methylation at promoters is associated with transcriptional repression, whereas gene body methylation is generally associated with gene expression. Extrinsic factors such as age, diets and lifestyle affect DNA methylation which consequently alters gene expression. Stress, anxiety, depression, life satisfaction, emotion among numerous other psychological factors also modify DNA methylation patterns. This correlation is frequently investigated in four candidate genes; NR3C1, SLC6A4, BDNF and OXTR, since regulation of these genes directly impact responses to social situations, stress, threats, behaviour and neural functions. Such studies underpin the hypothesis that DNA methylation is involved in deviant human behaviour, psychological and psychiatric conditions. These candidate genes may be targeted in future to assess the correlation between methylation, social experiences and long-term behavioural phenotypes in humans; and may potentially serve as biomarkers for therapeutic intervention.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kader F,Ghai M,Maharaj Ldoi
10.1016/j.bbr.2017.12.004subject
Has Abstractpub_date
2018-07-02 00:00:00pages
47-65eissn
0166-4328issn
1872-7549pii
S0166-4328(17)31140-3journal_volume
346pub_type
杂志文章,评审abstract：:In an eight-arm radial maze, working and reference memory can be assessed simultaneously in the fixed position of reward task (FPRT) in which half of the arms are baited and their positions are fixed throughout the training trails. We characterized performance of rats in the variable position of reward task (VPRT), in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00460-0
更新日期：2002-08-21 00:00:00
abstract：INTRODUCTION:Visuospatial neglect can occur in peripersonal and extrapersonal space. The dorsal visual pathway is hypothesized to be associated with peripersonal, and the ventral pathway with extrapersonal neglect. We aimed to evaluate neural substrates of peripersonal versus extrapersonal neglect, separately for egoce...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.06.010
更新日期：2019-01-01 00:00:00
abstract：:This series of studies explored the operant response rates for pup-reinforcement of female Sprague Dawley rats that were either postpartum or cycling and sustained lesions of the medial preoptic area (mpoa), the lateral amygdala, the nucleus accumbens, or sham lesions. The last experiment tested the effects on operant...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(98)00109-0
更新日期：1999-04-01 00:00:00
abstract：:Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00207-8
更新日期：2001-09-14 00:00:00
abstract：:Male rats both eat more and weigh more than females. Differences in food intake and body weight result, at least partly, from differences in gonadal hormone secretions. The present experiments were designed to investigate whether sex differences in food motivation might contribute to the behavioral differences observe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90118-0
更新日期：1988-03-01 00:00:00
abstract：:The postpartum period is characterized by complex hormonal changes, but human imaging studies in the postpartum period have thus far predominantly focused on the neural correlates of maternal behavior or postpartum depression, whereas longitudinal studies on neural correlates of cognitive function across the postpartu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.12.003
更新日期：2013-03-15 00:00:00
abstract：:Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112066
更新日期：2019-11-05 00:00:00
abstract：:Cholinergic systems have been linked to cognitive processes such as attention, learning and mnemonic function. However, other neurotransmitter systems, such as the serotonergic one, which may have only minor effects on cognitive function on their own, interact with cholinergic function and their combined effects may h...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00157-b
更新日期：1995-03-01 00:00:00
abstract：:Ultrasonic vocalization (USV) was found useful for differentiating fear and anxiety in rats. These affective states were established through a Pavlovian conditioning procedure. Danger stimulus, preceding unavoidable tail shock, elicited acute fear. Intertrial situational cues evoked anxiety. A safety signal (SS) indic...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00321-2
更新日期：2003-04-17 00:00:00
abstract：:Substantial evidence suggests that cerebral deposition of the neurotoxic fibrillar form of amyloid precursor protein, β-amyloid (Aβ), plays a critical role in the pathogenesis of Alzheimer's disease (AD). Yet, many aspects of AD pathology including the cognitive symptoms and selective vulnerability of cortically proje...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.07.046
更新日期：2014-11-01 00:00:00
abstract：:In schizophrenia patients negative symptoms and cognitive impairment often persist despite treatment with second generation antipsychotics leading to reduced quality of life and psychosocial functioning. One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal...
journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bbr.2012.09.034
更新日期：2013-01-15 00:00:00
abstract：:Rodents previously (Trial 1) experienced in the elevated plus-maze (EPM) apparatus no longer respond to anxiolytic-like drugs during retesting (Trial 2). In view of the fact that the dorsolateral periaqueductal gray (dlPAG) modulates fear/anxiety-like behavior, the present study sought to determine its role in this ph...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.03.010
更新日期：2005-07-01 00:00:00
abstract：:We review some of the evidence for structural changes in synapses in response to environmental stimulation. These include changes in synapse number, in distribution of presynaptic vesicles, in synaptic bouton size, and complex changes in the shape and size of synaptic contact zones. Increased numbers of postsynaptic p...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00116-w
更新日期：1995-01-23 00:00:00
abstract：:A new place navigation test was used to estimate the spatial orientation abilities of male and female rats. Animals had to avoid a room frame defined area on a rotating arena, entering of which was punished by mild footshock, i.e. rats had to avoid the same place in the room but different parts of the floor, which was...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00128-x
更新日期：2000-01-01 00:00:00
abstract：:Granular cell proliferation in the adult hippocampus decreases during aging and after chronic stress, while it can be increased by physical activity or treatment with the antidepressant fluoxetine. We investigated whether the physical and cognitive stimulation accompanied by stress in the commonly used Morris water ma...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.04.013
更新日期：2005-08-30 00:00:00
abstract：:Working with mice represents a smart method to study pathophysiological mechanisms in vivo. However, using animals as model organisms also bears immense caveats. While many aspects in animal research are meanwhile standardized (e.g. nutrition, housing, health) the breeding environment remains unaddressed. Moreover, si...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.11.007
更新日期：2015-02-15 00:00:00
abstract：:Exposure to social stress increases the vulnerability of experimental animals to the rewarding effects of cocaine and it has been suggested that the glutamatergic system could be involved in these effects of stress. The aim of this work is to determine the role of N-methyl-d-aspartate (NMDA) glutamate receptors in the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.025
更新日期：2019-04-01 00:00:00
abstract：:Voice disorders manifest in the early stages of Parkinson disease (PD), suggesting the vulnerability of the laryngeal sensorimotor system to mild alterations in dopamine signaling. Previous research has demonstrated that manipulations of central dopamine result in acoustic changes in rat ultrasonic vocalization (USV) ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.06.006
更新日期：2013-09-01 00:00:00
abstract：:This study examines the effects of ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) on serial contextual memory retrieval in non-stress and stress conditions. Independent groups of mice learned two successive contextual serial discriminations (D1 and D2) in a four-hole board. The discriminations d...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.05.014
更新日期：2009-11-05 00:00:00
abstract：:The central visual system of white zebra finches is physiologically and anatomically different from normally coloured (wild type) animals. The main difference to normal birds is an enhanced response to ipsilateral stimulation in all areas of the tectofugal visual pathway. Previous experiments indicated that besides an...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.02.016
更新日期：2006-06-03 00:00:00
abstract：:Spatial memory enables us to locate places and objects in space, to determine our position and manage spatial relationships in our environment. Our operations are displayed in a space that sometimes is inaccessible. In this case, the impossibility of movement within the context forces individuals to rely on the inform...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.03.022
更新日期：2018-07-16 00:00:00
abstract：:Previous studies on starling song had shown that different categories of songs are produced and discriminated. In the present study, both playback experiments in the field and electrophysiological recordings of single cells in field L (main central auditory area) were used in order to understand the perceptual bases o...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00191-1
更新日期：2000-09-01 00:00:00
abstract：:The rat medial prefrontal cortex has been suggested to be involved in executive functions and, more specifically, in working memory and response selection. Here, we looked for prefrontal neural correlates as rats performed a modified radial arm maze task that taxed such functions. Rats had to learn the position of fou...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.004
更新日期：2010-06-19 00:00:00
abstract：:It was previously shown [17] that visual movement sensitive neurons lacking selectivity in the anterior parts of the dorsal superior temporal sulcus (STP) of monkeys exhibited selective responses to externally moved objects and failed to respond to the sight of the animal's own limb movements. This paper describes a s...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(95)00193-x
更新日期：1996-04-01 00:00:00
abstract：:The endocannabinoid system is capable of modulating multiple physiological brain functions including learning and memory. Moreover, there is evidence that the processes of acquisition and consolidation have distinct biological basis. We used the cannabinoid agonist WIN 55,212-2 (WIN-2) to investigate whether chronic C...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112231
更新日期：2020-01-13 00:00:00
abstract：:The present study investigated the involvement of nitric oxide (NO) in phencyclidine (PCP)-induced place aversion and preference in the place conditioning paradigm. PCP-induced place aversion in naive mice was dose-dependently attenuated by administration of N(G)-nitro-L-arginine methyl ester (L-NAME), a NO synthase (...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00274-6
更新日期：2000-12-05 00:00:00
abstract：:This paper provides the first report of spatial learning in guinea pigs using the Morris water maze (MWM). Male and female guinea pigs were trained for 5 consecutive days (8 trials/day; acquisition phase) in either the visible (cued) or the hidden (non-cued) platform version of the MWM. In both tests, guinea pigs lear...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00188-7
更新日期：2001-09-28 00:00:00
abstract：:Autism spectrum disorders (ASD) represent a class of neurodevelopmental disorders characterized by impairments in social interaction, verbal and non-verbal communication, as well as restricted interests and repetitive behavior. This latter class of symptoms often includes features such as compulsive behaviors and resi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.10.032
更新日期：2012-02-01 00:00:00
abstract：:Serotonin (5-HT) and testosterone (T) have both been implicated in the regulation of aggression. Findings in humans however are very inconclusive, with respect to main effects of either system. Animal models implicate T to modulate 5-HT system activity, and furthermore have shown behaviorally relevant interactions of ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.09.006
更新日期：2010-01-05 00:00:00
abstract：:In order to automate a simultaneous visual discrimination system, a Sutherland jumping-stand box was modified by adding two lateral alleys which connect the feeder compartment with the starting box. By means of a digital interface, this modified box was connected to an Apple IIe PC. A group of rats (n = 8) was trained...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80126-3
更新日期：1992-04-10 00:00:00
