Increased Free Testosterone Levels in Men with Uncontrolled Type 2 Diabetes Five Years After Randomization to Bariatric Surgery.

Abstract:

:Hypogonadism frequently occurs in male patients with type 2 diabetes (T2DM) and is linked to insulin resistance and inflammation. Testosterone levels rise acutely in obese patients following bariatric surgery, though long-term changes have not been investigated in a randomized controlled trial. This study evaluated obese men with T2DM randomized to either bariatric surgery or medical therapy. Testosterone, gonadotropins, body composition, insulin sensitivity, and inflammatory markers were evaluated in 32 patients at baseline and at 5 years. Surgical patients had 47.4% increase in free testosterone compared to medical therapy patients who had 2.2% decrease (P = 0.013). Increase in free testosterone correlated with reduction in body weight, high-sensitivity C-reactive protein (hsCRP), and leptin levels. Prolonged improvements in testosterone levels after bariatric surgery in T2DM are found to be related to reduction in body weight and adipogenic inflammation.

journal_name

Obes Surg

journal_title

Obesity surgery

authors

Pham NH,Bena J,Bhatt DL,Kennedy L,Schauer PR,Kashyap SR

doi

10.1007/s11695-017-2881-5

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

277-280

issue

1

eissn

0960-8923

issn

1708-0428

pii

10.1007/s11695-017-2881-5

journal_volume

28

pub_type

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