Abstract:
:Hypogonadism frequently occurs in male patients with type 2 diabetes (T2DM) and is linked to insulin resistance and inflammation. Testosterone levels rise acutely in obese patients following bariatric surgery, though long-term changes have not been investigated in a randomized controlled trial. This study evaluated obese men with T2DM randomized to either bariatric surgery or medical therapy. Testosterone, gonadotropins, body composition, insulin sensitivity, and inflammatory markers were evaluated in 32 patients at baseline and at 5 years. Surgical patients had 47.4% increase in free testosterone compared to medical therapy patients who had 2.2% decrease (P = 0.013). Increase in free testosterone correlated with reduction in body weight, high-sensitivity C-reactive protein (hsCRP), and leptin levels. Prolonged improvements in testosterone levels after bariatric surgery in T2DM are found to be related to reduction in body weight and adipogenic inflammation.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Pham NH,Bena J,Bhatt DL,Kennedy L,Schauer PR,Kashyap SRdoi
10.1007/s11695-017-2881-5subject
Has Abstractpub_date
2018-01-01 00:00:00pages
277-280issue
1eissn
0960-8923issn
1708-0428pii
10.1007/s11695-017-2881-5journal_volume
28pub_type
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