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Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.

Abstract：

Background:Through its effects on the immune system, smoking may facilitate influenza virus infection, its severity and its most frequent complications. The objective was to investigate the smoking history as a risk factor for influenza hospitalization and influenza vaccine effectiveness in elderly smokers/ex-smokers and non-smokers. Methods:We carried out a multicenter case-control study in the 2013-2014 and 2014-2015 influenza seasons. Cases aged ≥65 years and age-, sex-matched controls were selected from 20 Spanish hospitals. We collected epidemiological variables, comorbidities, vaccination history and the smoking history. The risk of hospitalization due to smoking (current smokers and ex-smokers) was determined using the adjusted odds ratio (aOR) with conditional logistic regression models. Vaccine effectiveness (VE) was calculated using the formula: VE = (1 - aOR) × 100. Results:We studied 728 cases and 1826 controls. Cases had a higher frequency of smoking (47.4% vs 42.1%). Smoking was associated with an increased risk of influenza hospitalization (aOR = 1.32, 95% CI: 1.04-1.68). Influenza vaccine effectiveness in preventing hospitalization was 21% (95% CI: -2 to 39) in current/ex-smokers and 39% in non-smokers (95% CI: 22-52). Conclusions:A history of smoking may increase the risk of hospitalization in smokers and ex-smokers. Preventing smoking could reduce hospitalizations due to influenza. Smokers and ex-smokers should be informed of the risk of hospitalization due to influenza infection, and encouraged to stop smoking. Smokers should be considered an at-risk group to be aggressively targeted for routine influenza vaccination.

journal_name

Eur J Public Health

journal_title

European journal of public health

authors

Godoy P,Castilla J,Soldevila N,Mayoral JM,Toledo D,Martín V,Astray J,Egurrola M,Morales-Suarez-Varela M,Domínguez A,CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain*.

doi

10.1093/eurpub/ckx130

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

150-155

issue

eissn

1101-1262

issn

1464-360X

pii

4108100

journal_volume

pub_type

杂志文章,多中心研究

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Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.