Abstract:
:Fibers were spun by the downward configuration of the wet spinning technique. This configuration is capable of encapsulating nonspherical and/or coarse particles. We examined encapsulation of propranolol hydrochloride and the ability of the fibers to act as a sustained-release delivery system for propranolol hydrochloride as a model drug. The U.S.P. basket dissolution method was used to evaluate the in vitro drug release kinetics and the effect of the aspect ratio (length/diameter) on drug release. For in vivo evaluation, selected fibers were administered to dogs in gelatin capsules. The results of these in vitro and in vivo studies were compared to those obtained with a marketed sustained-release propranolol product (Inderal LA). The fiber delivery system provided a sustained-release profile of plasma propranolol concentrations similar to that observed with Inderal LA.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Hussain MA,DiLuccio RC,Shefter E,Hurwitz ARdoi
10.1023/a:1015982521706subject
Has Abstractpub_date
1989-12-01 00:00:00pages
1052-5issue
12eissn
0724-8741issn
1573-904Xjournal_volume
6pub_type
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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abstract:PURPOSE:To develop an isolated perfused rat liver (IPRL) model with low baseline levels of tumor necrosis factor (TNF)-alpha in the outlet perfusate to study the effects of immunostimulants and immunosuppressants on the release of TNF-alpha from this organ. METHODS:Isolated rat livers were perfused with a buffer conta...
journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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更新日期:1999-09-01 00:00:00
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更新日期:2005-12-01 00:00:00
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015839426229
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更新日期:2006-06-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:1999-08-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2016-03-01 00:00:00
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-009-9852-z
更新日期:2009-06-01 00:00:00
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journal_title:Pharmaceutical research
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更新日期:2006-01-01 00:00:00