Abstract：
INTRODUCTION:Oxidative stress has been implicated in various disease states and ischemia/reperfusion injury is a direct consequence of oxidative stress in lung transplantation. Because the success rate of organ transplantation in which ischemia/reperfusion is inevitable is highly influenced by oxidative stress, development of strategies to control oxidative stress would be beneficial. Here we identified natural compounds to reduce oxidative stresses in isolated mouse lungs. METHODS:We screened compounds associated with antioxidative stress in 200 plant extracts by monitoring the activities of nuclear factor erythroid 2-related factor 2 (NRF2). Compounds found to ameliorate antioxidative stress were enriched and mice were administered the extract orally every day for 1 week. Then, the lungs were isolated and cultured in the culture medium at 37 °C. Lung damage was monitored by lactate dehydrogenase (LDH) released in the culture medium. Arterial (left ventricle) blood gas levels were also monitored after hilar clamping. RESULTS:We found that Callicarpa longissima extract was rich in NRF2 activators. The responsible compounds were carnosic acid and its oxidative product, carnosol. Carnosol induced heme-oxygenase 1 (HO-1) expression, which is downstream of NRF2, more efficiently than carnosic acid. CONCLUSIONS:Lungs from mice treated with C longissima extract were less damaged than those from control mice and accompanied by HO-1 induction. These results suggest that carnosol is a candidate compound to increase the success rate of lung transplantation.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Kawamura T,Momozane T,Sanosaka M,Sugimura K,Iida O,Fuchino H,Funaki S,Shintani Y,Inoue M,Minami M,Kawahara N,Takemori H,Okumura Mdoi
10.1016/j.transproceed.2015.05.004subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1657-61issue
6eissn
0041-1345issn
1873-2623pii
S0041-1345(15)00518-7journal_volume
47pub_type
杂志文章abstract：OBJECTIVES:Laparoscopic donor nephrectomy has become the method of choice for removal of living donor kidneys. The ENDO GIA stapler is commonly used for division of the renal vessels, but it can lead to some loss of graft vascular length. Besides, stapler malfunction can occur. In this study, we report our experience u...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.06.016
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:The efficacy of newer antifungal agents to provide effective prophylaxis during stem cell transplantation has not yet been established. We compared the clinical outcomes using of the newer triazoles and echinocandins for antifungal prophylaxis. METHODS:We electronically searched the databases of Cochrane Cen...
journal_title：Transplantation proceedings
pub_type： 杂志文章,meta分析
doi：10.1016/j.transproceed.2012.07.149
更新日期：2013-01-01 00:00:00
abstract：:The model for end-stage liver disease (MELD) has been an excellent predictor of 3-month mortality among cirrhotic patients awaiting orthotopic liver transplantation (OLT). The aim of this study was to evaluate whether the preoperative MELD score predicts short-term prognosis after OLT. We enrolled 98 adult liver trans...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2006.06.031
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abstract：BACKGROUND:Pulmonary hypertension in the setting of renal transplantation has been associated with early allograft dysfunction and increased mortality, but this relationship has not been extensively studied. METHODS:We performed a retrospective cohort study of adult patients who underwent their first renal transplanta...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2017.01.085
更新日期：2017-01-01 00:00:00
abstract：UNLABELLED:Pancreas transplant (Ptx) is the gold standard for the treatment of type I diabetes, mainly when associated with renal failure. The number of Ptx is increasing worldwide, but in developing countries, such as Brazil, the number of centers is small and transplant surgeons need to practice the technique. METHO...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2006.06.056
更新日期：2006-07-01 00:00:00
abstract：:We report a case of anuria in a 42-year-old female kidney transplant patient that occurred secondary to extrinsic compression from a large kidney being placed extraperitoneally in a small iliac fossa. Prompt reexploration in the immediate postoperative period resulted in salvage of the graft with restoration of kidney...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2006.02.139
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:Expansion of donor criteria has become necessary with the increasing number of liver transplantation candidates, as aged donors who have been considered to yield marginal organs. METHODS:Our database of 477 liver transplants (OLT) included 55 cases performed from donors at least 70 years old vs 422 with y...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2005.10.040
更新日期：2005-11-01 00:00:00
abstract：UNLABELLED:An open, single arm, prospective clinical trial to assess the efficacy and safety of basiliximab (Simulect) combined with cyclosporine microemulsion (Neoral), steroids, and azathioprine was performed in four centers in Chile, two adult and two pediatric. The 23 patients who were enrolled were followed for 12...
journal_title：Transplantation proceedings
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.transproceed.2003.09.098
更新日期：2003-11-01 00:00:00
abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title：Transplantation proceedings
pub_type： 撤回出版物
doi：10.1016/j.transproceed.2019.02.036
更新日期：2020-07-01 00:00:00
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journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2010.09.006
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Prolonged initial intensive care unit (ICU) stay after liver transplantation (LT) is associated with prolonged total hospitalization, increased hospital mortality, and impaired patient and graft survival. Recent data suggested that model for end-stage liver disease (MELD) score at the time of LT and the leng...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2018.02.143
更新日期：2018-09-01 00:00:00
abstract：:The role of hemopoietic stem cell transplantation (HSCT) is not well established in certain types of lymphoma, such as those with a high relapse risk or relapsing after initial therapy. New chemotherapeutic schemes and immunotherapy have improved survival of these patients. Nevertheless, there is not enough evidence r...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2013.11.007
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Tacrolimus and mycophenolic acid (MPA) are the most important immunosuppressive drugs in modern heart transplantation. The pharmacokinetics of tacrolimus are best described by a 2-compartment model. MPA has very variable pharmacokinetics. The aim of this research was to compare kinetics of the immunosuppress...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2020.03.006
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:NKG2D, an activating receptor, may trigger NK and CD8+ T cells. Ligands for NKG2D and major histocompability complex class I chain-related antigen (MIC) have been reported to be expressed in rejected human renal allografts. MIC-NKG2D engagement may induce natural killer (NK) cell activation providing T-cel...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2006.06.013
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Klebsiella pneumoniae New Delhi metallo-beta-lactamase-1 (NDM-1) strains have recently become a new threat in kidney transplant recipients due to the strains' resistance to almost all antibiotics, including carbapenems. METHODS:We present a case series of 3 patients with urinary tract infections (UTIs) caus...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2016.01.060
更新日期：2016-06-01 00:00:00
abstract：:Overall, the results seen in this study are encouraging. In this high-risk group of patients where the expected disease rate would normally be at least 55% to 60% without prophylaxis, a combination protocol of GCV, ACV, and CMVIG limited the rate of disease to 19%. When disease occurred, it was generally mild and easi...
journal_title：Transplantation proceedings
pub_type： 杂志文章,评审
doi：
更新日期：1996-12-01 00:00:00
abstract：INTRODUCTION:The favorable knowledge of the concept of brain death (BD) is a determinant for organ donation. OBJECTIVE:To analyze the level of knowledge of the concept of BD in the population of Cienfuegos (Cuba) and determine the factors that condition it. METHODS:Sample of Cubans residing in Cienfuegos (n = 636) st...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2019.12.023
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:The objective of the present study was to analyze the knowledge and acceptance of the brain death (BD) concept among nursing students. METHODS:The study was undertaken in the academic year of 2011 to 2012 in nursing students from the University of the South of Poland. The sample was carried out in compulsor...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2015.10.016
更新日期：2015-11-01 00:00:00
abstract：:Pre-BTs significantly improve the survival rate for first cadaver transplants, by a mechanism that remains obscure. The maximal influence is seen with smaller numbers of pre-BTs (1-5 units), but is also observed with larger numbers of pre-BTs. The possible beneficial influence of Tx-BTs on graft survival is not proven...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:We analyzed the function and outcome of 16 kidney transplants performed in our hospital from non-heart-beating donors who were harvested at other hospitals. The cold ischemia times were longer and the delayed graft function rates higher. However, graft function was no different from that of kidneys from heart-beating ...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2006.02.031
更新日期：2006-04-01 00:00:00
abstract：:To assess survival of grafts after uncontrollable rejection, one performs backtransplantation from the recipient to the donor. This study investigated backtransplantation in an animal model. Hearts were transplanted heterotopically in rats. After a few days, the transplanted heart grafts were harvested from the recipi...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2005.01.009
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:BK viremia and nephropathy are increasing problems in renal transplant recipients. The absence of a safe and effective antiviral therapy made screening-based prevention a recommended strategy. The prevalence of its reactivation among recipients of kidney transplants in the Middle East has not been well estab...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2014.11.060
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to describe the clinical and microbiological characteristics of the infectious complications among simultaneous pancreas-kidney transplantations (SPKT). MATERIALS AND METHODS:Among the first 45 SPKT the mean age was 34 years (range, 21 to 49) and the mean duration of follow-up 1...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2004.03.114
更新日期：2004-05-01 00:00:00
abstract：:Pancreatic islet cells of rats obtained by the collagenase digestion method were preserved from 7 to 10 days at -80 degrees C in a deep freezer or at -196 degrees C in liquid nitrogen with Dulbecco modified Eagle's medium, supplemented with 10% or 20% DMSO (dimethyl sulfoxide); thawing was performed in a 37 degree C w...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:We report the case of a 62-year-old man with short-bowel syndrome, referred for intestinal transplantation, who had esophageal varices (EV) due to superior vena cava (SVC) thrombosis. Pretransplantation work-up revealed protein S deficiency. Results of liver function tests were normal. Upper endoscopy showed grade II ...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2009.12.024
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:A patient undergoing renal transplantation presents unique problems to the anesthetist, as almost every body system is affected. The combined spinal-epidural technique has become popular in lower abdominal surgeries because it offers the advantages of both spinal and epidural techniques. We review our expe...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.03.027
更新日期：2008-05-01 00:00:00
abstract：:Alpha-1 antitrypsin (AAT) is a serine protease inhibitor able to prevent diabetes onset in nonobese diabetic (NOD) mice and to prolong islet allograft survival in a nonautoimmune murine model. In this study, we explored the effect of chronic administration of human AAT (hAAT) on allogeneic (C57BL/6) islet graft surviv...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.02.010
更新日期：2008-03-01 00:00:00
abstract：:Sirolimus (SRL) has become an option in kidney transplantation, especially among patients who develop chronic allograft nephropathy (CAN). This study sought to evaluate the safety and efficacy of SRL in 103 kidney recipients of mean age 40 years, including 78 recipients of organs from deceased donors. The major reason...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2007.04.021
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Caring for patients with end-stage renal disease (ESRD) is resource intense, and health care costs for this small segment of the population continue to rise. When compared to long-term dialysis as a therapy for ESRD, kidney transplantation increases survival, improves quality of life, and is cost saving. ME...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2007.03.019
更新日期：2007-06-01 00:00:00
abstract：INTRODUCTION:Liver transplantation is an important health and health care issue for Canadians. Very few studies have estimated the survival results among liver transplant patients infected with hepatitis C virus (HCV) in Canada. METHODS:We carried out a retrospective cohort study to analyze 1- to 5-year survival rates...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.03.089
更新日期：2008-06-01 00:00:00
