Abstract：
OBJECTIVE:To undertake a systematic review of the evidence for the effect of acetylcholinesterase inhibitors (AChEIs) on cognition late after moderate or severe traumatic brain injury. BACKGROUND:Cognitive impairment after traumatic brain injury has significant consequences for the individual and society. Cholinergic pathways play an important role in cognitive processing and a hypocholinergic state exists in the chronic phases after traumatic brain injury. AChEIs are already used off-label to treat patients with traumatic brain injury. DATA SOURCES AND STUDY SELECTION:PubMed, CINAHL, PsycINFO, the Cochrane Collaboration and Web of Science were searched with pre-specified criteria between 1999 and June 2015. DATA EXTRACTION AND SYNTHESIS:A total of 153 studies were identified. None met pre-specified criteria. The criteria were revised in order to identify studies that may provide useful information despite some risk of bias. Three studies met the revised criteria and were evaluated by 2 reviewers using the Swedish Council on Health Technology Assessment grading system, based on GRADE. Key findings and limitations were tabulated. One study found no effect and 2 found limited effect. CONCLUSION:Large randomized controlled studies are needed to establish whether AChEIs are effective for cognition late after moderate or severe traumatic brain injury. Clinicians should be aware of the weak evidence base when considering the off-label use of AChEIs.
journal_name
J Rehabil Medjournal_title
Journal of rehabilitation medicineauthors
Bengtsson M,Godbolt AKdoi
10.2340/16501977-2040subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1-5issue
1eissn
1650-1977issn
1651-2081journal_volume
48pub_type
杂志文章,评审abstract：OBJECTIVE:The aim of this study was to explore the experiences of patients with burnout during a rehabilitation programme. PATIENTS AND METHODS:Eighteen patients with burnout were interviewed at the end of a one-year rehabilitation programme. The programme consisted of 2 groups, one with a focus on cognitively-oriente...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0534
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To investigate the validity and reliability of the Tampa Scale for Kinesiophobia Heart (TSK-SV Heart), a brief questionnaire to detect kinesiophobia (fear of movement) in patients with coronary artery disease. DESIGN:Methodological research (cross-sectional study). SUBJECTS:A total of 332 patients, mean age...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0942
更新日期：2012-04-01 00:00:00
abstract：:Oral baclofen has long been a mainstay in the management of spasticity. This review looks at the clinical evidence for the efficacy and safety of oral baclofen in patients with spasticity of any origin or severity, to determine whether there is a rationale for the use of intrathecal baclofen. Results suggest that oral...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,评审
doi：10.2340/16501977-2211
更新日期：2017-03-06 00:00:00
abstract：OBJECTIVE:To analyse factors related to subjective non-cognitive and cognitive complaints in patients with spontaneous subarachnoid haemorrhage. SUBJECTS:Twenty-seven patients with subarachnoid haemorrhage and 27 age-, sex- and education-matched healthy controls. METHODS:A battery of cognitive tests measuring visuo-s...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.1080/16501970310017414
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:To compare individual, group and combined intervention formats for improving goal attainment and psychosocial function following acquired brain injury. DESIGN:Randomized controlled trial, waiting list controls. PARTICIPANTS:Thirty-five participants with a mean time of 5.29 years (standard deviation = 3.9) s...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,随机对照试验
doi：10.2340/16501977-0124
更新日期：2008-02-01 00:00:00
abstract：:There is a need to develop a contemporary and internationally accepted conceptual description of physical and rehabilitation medicine (PRM). The process of evolving such a definition can now rely on the unifying conceptual model and taxonomy of the International Classification of Functioning, Disability and Health (IC...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0044
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To explore construct(s) (ability, capability, actual performance, and/or perceived difficulty) of activities of daily living measures that have been used in randomized controlled trials. METHODS:Three databases (Medline, CINAHL, and OTSeeker) were searched. A questionnaire was sent to the author of each elig...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-1008
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:The interhemispheric competition model proposes that the functional recovery of motor deficits in patients after stroke can be achieved by increasing the excitability of the affected hemisphere or decreasing the excitability of the unaffected hemisphere. We investigated whether bilateral repetitive transcrani...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,随机对照试验
doi：10.2340/16501977-0454
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of individualized manual physiotherapy and exercises compared with individualized exercises alone in patients with shoulder impingement syndrome. DESIGN:Randomized controlled trial. SUBJECTS:Patients with shoulder impingement of more than 4 weeks' duration. METHODS:Patients in the...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,随机对照试验
doi：10.2340/16501977-1142
更新日期：2013-05-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,随机对照试验
doi：10.2340/16501977-1095
更新日期：2013-02-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0237
更新日期：2008-08-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,随机对照试验
doi：10.2340/16501977-0988
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Goal attainment scaling represents a unique approach to identifying and quantifying individualized, meaningful treatment outcomes, and its use in the rehabilitation medicine setting is increasing. The aim of this paper is to discuss the available literature for goal attainment scaling in patients with acquire...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0664
更新日期：2011-01-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0580
更新日期：2010-07-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,多中心研究
doi：10.2340/16501977-0375
更新日期：2009-06-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.1080/165019702317242686
更新日期：2002-01-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章,随机对照试验
doi：10.2340/16501977-2593
更新日期：2019-10-29 00:00:00
abstract：OBJECTIVE:To investigate predictive factors for percutaneous endoscopic gastrostomy (PEG) removal, thereby minimizing unnecessary PEG insertion in post-stroke dysphagia. DESIGN:Retrospective cohort study. PATIENTS:A total of 49 patients who undertook PEG tube insertion for post-stroke dysphagia. METHODS:Patients wer...
journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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pub_type： 杂志文章,meta分析
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journal_title：Journal of rehabilitation medicine
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pub_type： 杂志文章,meta分析
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更新日期：2020-02-07 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
doi：10.2340/16501977-0944
更新日期：2012-03-01 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
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更新日期：2015-08-18 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
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更新日期：2019-12-16 00:00:00
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journal_title：Journal of rehabilitation medicine
pub_type： 杂志文章
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journal_title：Journal of rehabilitation medicine
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更新日期：2017-07-07 00:00:00
