Abstract:
:Graft-versus-host disease (GVHD) is one of the major complications after hematopoietic stem cell transplantation and is responsible for post-therapeutic morbidity, mortality, and poor quality of life of recipients. Sclerodermatous graft-versus-host disease (sGVHD) is a rare variant of chronic GVHD characterized by deposition of collagen in the skin and other soft tissues and resulting in loss of range of motion and functional capabilities. Treatment of sGVHD is challenging and largely limited by systemic side effects. Ultraviolet A1 phototherapy has been reported to be effective in connective tissue disorders, including sGVHD. We report a case of sGVHD in a 15-year-old girl that was resistant to traditional therapy but showed improvement in cutaneous symptoms with ultraviolet A1 phototherapy three times a week for 6 weeks (10 J/cm(2) single dose, 180 J/cm(2) cumulative dose).
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Lazzeri L,Tripo L,Pescitelli L,Ricceri F,Prignano Fdoi
10.1111/pde.12794subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e99-102issue
2eissn
0736-8046issn
1525-1470journal_volume
33pub_type
杂志文章abstract::We describe a 16-year-old boy with intestinal lymphangiectasia, lymphedema of the limbs and genitalia, mild mental retardation, and facial anomalies (Hennekam syndrome) and cutaneous lesions. Severe edema in the genital area created a gigantic mass that included the scrotum and penis. Numerous grouped red-violaceous p...
journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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