Abstract:
:We present a case of a large congenital hemangioma (CH) on the neck causing cardiac failure and thrombocytopenia in a female neonate. A trial of medical therapy with corticosteroids and propranolol was attempted, but the patient ultimately underwent definitive treatment with embolization and surgical resection with a positive outcome. A review of the English language literature revealed 16 previously reported cases of CHs complicated by congestive heart failure. This series supports known demographic features of CHs, including a lack of gender discrepancy and a predilection to affect the head and neck. These CHs are rarely diagnosed in utero; most patients present with a mass at birth. Cardiac failure is identified prenatally or in the first days of life. A mild to moderate thrombocytopenia and coagulopathy, which is likely transient and distinct from classic Kasabach-Merritt phenomenon, accompanies many of these cases. There is a 30% associated mortality rate. Both medical and interventional treatment modalities have been reported. Steroids are the most commonly used medication, but without any clear benefit. We hypothesize that, based on its possible mechanisms of action,propranolol may be a more effective treatment for CHs requiring treatment. As surgical intervention may be necessary, we recommend a multidisciplinary approach to treating patients with problematic CHs.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Weitz NA,Lauren CT,Starc TJ,Kandel JJ,Bateman DA,Morel KD,Meyers PM,Kadenhe-Chiweshe A,Wu JK,Garzon MCdoi
10.1111/j.1525-1470.2012.01875.xsubject
Has Abstractpub_date
2013-11-01 00:00:00pages
e180-90issue
6eissn
0736-8046issn
1525-1470journal_volume
30pub_type
杂志文章,评审abstract::Henoch-Schönlein purpura (HSP) is an acute systemic vasculitis with unknown etiology, although several studies have found HSP to be related to cytokines such as tumor necrosis factor α, interleukin (IL)-1, and adhesion molecules. In the present study we determined the levels of cytokines such as IL-18 and endothelin-1...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12222
更新日期:2013-11-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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journal_title:Pediatric dermatology
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doi:10.1046/j.1525-1470.2000.017005352.x
更新日期:2000-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Pediatric dermatology
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更新日期:2009-05-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
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更新日期:1996-07-01 00:00:00
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journal_title:Pediatric dermatology
pub_type:
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更新日期:2020-07-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12002
更新日期:2013-05-01 00:00:00
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journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.12837
更新日期:2016-05-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.12635
更新日期:2015-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2008.00803.x
更新日期:2009-03-01 00:00:00
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journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.14160
更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/pde.14225
更新日期:2020-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2008.00651.x
更新日期:2008-03-01 00:00:00
abstract::Mutations in the p63 gene have been identified in five human disorders characterized by varying degrees of limb anomalies, ectodermal dysplasia, and facial clefts. We report a new point mutation in the p63 gene in a family in which the mother was initially diagnosed with Rapp-Hodgkin syndrome and her two offspring man...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2005.00105.x
更新日期:2005-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13995
更新日期:2019-11-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2005.22113.x
更新日期:2005-01-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1046/j.1525-1470.1999.99014.x
更新日期:1999-01-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01509.x
更新日期:2012-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1984.tb00446.x
更新日期:1984-07-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.1991.tb00856.x
更新日期:1991-09-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1525-1470.2000.01727.x
更新日期:2000-03-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1046/j.1525-1470.2002.00057.x
更新日期:2002-03-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/pde.12872
更新日期:2016-07-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1525-1470.2002.00229.x
更新日期:2002-11-01 00:00:00
abstract::Lichen sclerosus is a T-lymphocyte mediated chronic cutaneous disorder with predilection for the vulva. In prepubertal girls, lichen sclerosus presents as vulvar discomfort, pruritus, bruising/bleeding, discharge, dysuria, or painful defecation. Diagnosis and treatment of lichen sclerosus is of utmost importance in th...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2009.00922.x
更新日期:2009-05-01 00:00:00
abstract::The human papillomavirus (HPV) infects the squamous epithelium of the skin and produces common warts, plantar warts, and flat warts, which occur commonly on the hands, face, and feet. The objective of this study was to determine the presence of HPV in warts in children in order to associate the virus with the disease....
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12113
更新日期:2013-11-01 00:00:00