Postvaccination morphea profunda in a child.

Abstract:

:We report a new case of postvaccination morphea profunda (MP) in a child and discuss its different clinical presentations, prognosis, and therapy and its relationship with "solitary morphea profunda." A 2-year-old healthy girl presented with an induration of the anterior aspect of the left thigh of 9 months duration. The lesion had appeared 3 months after a third dose of diphtheria-tetanus-pertussis vaccine. Cutaneous examination showed an induration of 7 × 7 cm with an "orange peel" texture after pinching the skin. Histologic examination confirmed the diagnosis of MP. Systemic steroids (1 mg/kg/day) led to the stabilization of the lesion. After 4 months of treatment, we began the concomitant use of oral methotrexate (10 mg/wk) for 2 months. Methotrexate was then continued alone for 10 months, leading to a significant regression of the induration with no relapse.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Khaled A,Kharfi M,Zaouek A,Rameh S,Zermani R,Fazaa B,Kamoun MR

doi

10.1111/j.1525-1470.2011.01548.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

525-7

issue

4

eissn

0736-8046

issn

1525-1470

journal_volume

29

pub_type

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