Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses.

Abstract:

:Giardia lamblia, Cryptosporidium sp., and Entamoeba histolytica are important pathogenic intestinal parasites and are amongst the leading causes worldwide of diarrheal illness in humans. Diseases caused by these organisms, giardiasis, cryptosporidiosis, and amoebiasis, respectively, are characterized by self-limited diarrhea but can evolve to long-term complications. The cellular and molecular mechanisms underlying the pathogenesis of diarrhea associated with these three pathogens are being unraveled, with knowledge of both the strategies explored by the parasites to establish infection and the methods evolved by hosts to avoid it. Special attention is being given to molecules participating in parasite-host interaction and in the mechanisms implicated in the diseases' pathophysiologic processes. This review focuses on cell mechanisms that are modulated during infection, including gene transcription, cytoskeleton rearrangements, signal transduction pathways, and cell death.

journal_name

Front Microbiol

authors

Di Genova BM,Tonelli RR

doi

10.3389/fmicb.2016.00256

subject

Has Abstract

pub_date

2016-03-03 00:00:00

pages

256

issn

1664-302X

journal_volume

7

pub_type

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