Diagnostic performance and clinical feasibility of a point-of-care test for respiratory viral infections in primary health care.

Abstract:

Background:Inappropriately high levels of antibiotics are still prescribed in primary health care for respiratory tract infections (RTIs). Access to diagnostic point-of-care tests (POCTs) for RTIs might reduce this over-prescription. Objective:The purpose of our study was to determine the diagnostic performance and clinical feasibility of a recently developed diagnostic POCT for respiratory viruses, the mariPOC®, in a Dutch primary healthcare setting. Methods:In patients with RTI symptoms presenting to a family practice during the 2015-2016 winter season, we determined the test's sensitivity and specificity relative to polymerase chain reaction (PCR) testing performed in a laboratory. The clinical feasibility of the POCT was evaluated by interviewing general practitioners (GPs). Results:One or more respiratory viruses were detected in 54.9% of the patients (n = 204). For influenza A virus (n = 24), sensitivity of the POCT was 54.2% and specificity was 98.9%; for influenza B virus (n = 18), sensitivity was 72.2% and specificity 99.5%; and for respiratory syncytial virus (RSV) (n = 12), sensitivity was 50.0% and specificity 100%. In samples with higher viral load, sensitivity was 85.7% for influenza A, 78.6% for influenza B and 85.7% for RSV. The availability of a diagnostic test for respiratory viruses was appreciated by both patients and GPs. Conclusions:Our study shows that diagnostic POCTs for respiratory viruses might contribute to a precise and evidence-based diagnosis of RTIs and could positively influence prescription of antibiotics by GPs. However, before implementation in primary healthcare, diagnostic accuracy of the POCT needs improvement and it is impact on clinical decision making should be further assessed.

journal_name

Fam Pract

journal_title

Family practice

authors

Bruning AHL,de Kruijf WB,van Weert HCPM,Willems WLM,de Jong MD,Pajkrt D,Wolthers KC

doi

10.1093/fampra/cmx019

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

558-563

issue

5

eissn

0263-2136

issn

1460-2229

pii

3084395

journal_volume

34

pub_type

杂志文章
  • Acceptability of a guided self-help mental health intervention in general practice.

    abstract:BACKGROUND:People with subthreshold mental health syndromes are common in general practice and represent an important morbidity and disability burden. Management options are currently limited. We examined the acceptability of a novel ultra-brief guided self-help intervention designed specifically for use in this settin...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmr066

    authors: Collings S,Mathieson F,Dowell A,Stanley J,Jenkin G,Goodyear-Smith F,Hatcher S

    更新日期:2012-02-01 00:00:00

  • Comparing importance and performance from a patient perspective in English general practice: a cross-sectional survey.

    abstract:BACKGROUND:Patient experience and satisfaction are important indicators of quality in health care. Little is known about where to prioritize efforts to improve patient satisfaction. OBJECTIVES:To investigate patient satisfaction with primary care, as part of the Quality and Costs of Primary Care in Europe study in Eng...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmw004

    authors: Sirdifield C,Godoy Caballero A,Windle K,Jackson C,McKay S,Schäfer W,Siriwardena AN

    更新日期:2016-04-01 00:00:00

  • Meeting patient expectations of care: the major determinant of satisfaction with out-of-hours primary medical care?

    abstract:BACKGROUND:Client or consumer expectation is considered to influence their satisfaction with the service provided, but its importance has not been quantified in health care. OBJECTIVE:The aim of this study was to determine the effect of "patient expectations of care" on satisfaction with care provided by out-of-hours ...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/19.4.333

    authors: McKinley RK,Stevenson K,Adams S,Manku-Scott TK

    更新日期:2002-08-01 00:00:00

  • Diagnosing cancer in the bush: a mixed-methods study of symptom appraisal and help-seeking behaviour in people with cancer from rural Western Australia.

    abstract:BACKGROUND:Previous studies have focused on the treatment received by rural cancer patients and have not examined their diagnostic pathways as reasons for poorer outcomes in rural Australia. OBJECTIVES:To compare and explore symptom appraisal and help-seeking behaviour in patients with breast, lung, prostate or colore...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cms087

    authors: Emery JD,Walter FM,Gray V,Sinclair C,Howting D,Bulsara M,Bulsara C,Webster A,Auret K,Saunders C,Nowak A,Holman CD

    更新日期:2013-06-01 00:00:00

  • A brief case-finding questionnaire for common mental disorders: the CMDQ.

    abstract:OBJECTIVES:The aim of the study was to validate a new case-finding instrument for common mental disorders (CMDQ). METHODS:A cross-sectional, stratified, two-phase study was carried out in 28 general practices in Aarhus County, Denmark. 1785 consecutive patients, 18-65 years old, consulting 38 GPs with a new health pro...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmi025

    authors: Christensen KS,Fink P,Toft T,Frostholm L,Ornbøl E,Olesen F

    更新日期:2005-08-01 00:00:00

  • Arrhythmias in general practice: diagnostic value of patient characteristics, medical history and symptoms.

    abstract:BACKGROUND:Complaints possibly caused by arrhythmias are frequently seen in general practice. It is unclear to what extent such complaints can differentiate between arrhythmias and other pathology in general practice. OBJECTIVES:We aimed to assess the value of symptoms (a) in diagnosing arrhythmias in general practice...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/15.4.343

    authors: Zwietering PJ,Knottnerus JA,Rinkens PE,Kleijne MA,Gorgels AP

    更新日期:1998-08-01 00:00:00

  • Symptomatic effect of inhaled fenoterol in acute bronchitis: a placebo-controlled double-blind study.

    abstract::The symptomatic effect of inhaled fenoterol, a beta 2-agonist, 0.2 mg 4 times daily for 7 days, was evaluated in 80 patients with acute bronchitis examined at the Chest Clinic, Department of Medicine, University Hospital of Tromsø. Seventy-three patients completed the trial. End-point FEV1 (% predicted) showed a mean ...

    journal_title:Family practice

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/fampra/8.3.216

    authors: Melbye H,Aasebø U,Straume B

    更新日期:1991-09-01 00:00:00

  • Overall use of proctoscopy in general practice and possible relation to the stage of rectal cancer.

    abstract::Data from the Danish National Health Service records on activities of each of 146 general practices in the county of North Jutland, Denmark, were studied to determine whether the use of proctoscopy influenced the stage at which cancer of the rectum was recognized. Information for all patients in the county who receive...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/9.2.145

    authors: Sørensen HT,Ejlersen E,Møller-Petersen J,Rasmussen HH,Olesen F

    更新日期:1992-06-01 00:00:00

  • General practitioners' use of health education material. Results from a nationwide survey in Denmark in 1991. The Danish Health Education Study Group.

    abstract::In November 1991 69% of a random sample of 998 Danish general practitioners (GPs) participated in a survey by anonymously filling in a mailed questionnaire concerning the way in which they use health education in their practices. Among the participating GPs, 97% used health education material. The study showed differe...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/11.1.35

    authors:

    更新日期:1994-03-01 00:00:00

  • Multimorbidity and immigrant status: associations with area of origin and length of residence in host country.

    abstract:Aim:Multimorbidity is a growing phenomenon in primary care, and knowledge of the influence of social determinants on its evolution is vital. The aim of this study was to understand the relationship between multimorbidity and immigration, taking into account length of residence in the host country and area of origin of ...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmx048

    authors: Gimeno-Feliu LA,Calderón-Larrañaga A,Díaz E,Laguna-Berna C,Poblador-Plou B,Coscollar C,Prados-Torres A

    更新日期:2017-11-16 00:00:00

  • Consulting room computers and their effect on general practitioner-patient communication.

    abstract:BACKGROUND:in the western medical world, computers form part of the standard equipment in the consulting rooms of most GPs. As the use of a computer requires time and attention from GPs, this may well interfere with the communication process. Yet, the information accessed on the computer may also enhance communication....

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmq058

    authors: Noordman J,Verhaak P,van Beljouw I,van Dulmen S

    更新日期:2010-12-01 00:00:00

  • Maxillary sinusitis in adults: an evaluation of placebo-controlled double-blind trials.

    abstract:BACKGROUND:In general practice, acute sinusitis is frequently diagnosed and treated with antibiotics. OBJECTIVE:This study aimed to determine the evidence for the effectiveness of antibiotic treatment in acute maxillary sinusitis in adults by assessing the methodological quality of placebo-controlled double-blind rand...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/14.2.124

    authors: Stalman W,van Essen GA,van der Graaf Y,de Melker RA

    更新日期:1997-04-01 00:00:00

  • Doctors' strategies in prescribing drugs: the case of mood-modifying medicines.

    abstract:BACKGROUND:Little is known about doctors' decision-making processes in prescribing antidepressants and how this is handled. OBJECTIVE:To describe and understand doctors' strategies in prescribing mood-modifying drugs, especially when confronted with challenging patients or situations. METHODS:Face-to-face interviews ...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmi094

    authors: Kapmeyer A,Meyer C,Kochen MM,Himmel W

    更新日期:2006-02-01 00:00:00

  • Identifying patients who access musculoskeletal physical therapy: a retrospective cohort analysis.

    abstract:BACKGROUND:Musculoskeletal conditions are common and cause high levels of disability and costs. Physical therapy is recommended for many musculoskeletal conditions. Past research suggests that referral rates appear to have increased over time, but the rate of accessing a physical therapist appears unchanged. OBJECTIVE...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmaa104

    authors: Sharpe JA,Martin BI,Fritz JM,Newman MG,Magel J,Vanneman ME,Thackeray A

    更新日期:2020-10-12 00:00:00

  • Diagnostic performance of retinal digital photography for diabetic retinopathy screening in primary care.

    abstract:Introduction:We must study alternatives to structure an effective diabetic retinopathy screening program for Brazilian public health system. Objectives:Evaluate the diagnostic performance of retinal digital photography for diabetic retinopathy screening in primary care, accuracy of the family physician in diabetic ret...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmx020

    authors: Rosses APO,Ben ÂJ,Souza CF,Skortika A,Araújo AL,Carvalho G,Locatelli F,Neumann CR

    更新日期:2017-09-01 00:00:00

  • Consultation for and identification of child and adolescent psychological problems in Dutch general practice.

    abstract:BACKGROUND:Child and adolescent psychological problems are rarely brought to the attention of GPs. Children and adolescents with psychological problems who do visit their GP are seldom identified as such by GPs. OBJECTIVE:To investigate in a general population sample of 2,449 Dutch children and adolescents (4-17 years...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmi045

    authors: Zwaanswijk M,Verhaak PF,van der Ende J,Bensing JM,Verhulst FC

    更新日期:2005-10-01 00:00:00

  • Focus on early-career GPs: qualitative evaluation of a multi-faceted educational intervention to improve antibiotic prescribing.

    abstract:Background:We conducted an educational intervention emphasizing rational antibiotic prescribing in early-career General Practitioners (GP) in vocational training (trainees). The intervention consisted of an online introduction module, an online communication training module, face-to-face workshops, and cases to be disc...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmx074

    authors: Deckx L,Anthierens S,Magin PJ,Morgan S,McArthur L,Yardley L,Dallas A,Little P,van Driel ML

    更新日期:2018-01-16 00:00:00

  • A decline in patient disclosure of heterosexuality in the English General Practice Patient Survey: a longitudinal analysis of cross-sectional data.

    abstract:BACKGROUND:Persistent health inequalities in relation to both health care experiences and health outcomes continue to exist among patients identifying with a marginalized sexual orientation (MSO). OBJECTIVE:To compare the patterns of sexual orientation disclosure within primary care in England over a 5-year period. M...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmaa033

    authors: Cross H,Llewellyn CD

    更新日期:2020-10-19 00:00:00

  • A randomized controlled trial of direct access for laparoscopic sterilization.

    abstract:OBJECTIVES:The aim of this study was to establish and evaluate a direct access service for laparoscopic sterilization. METHODS:A pragmatic randomized controlled trial was carried out on a total of 232 women referred to Aberdeen Royal Infirmary for sterilization between 1 June 1996 and 31 March 1997, from 57 general pr...

    journal_title:Family practice

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/fampra/18.1.1

    authors: McKessock L,Smith BH,Scott A,Graham W,Terry PB,Templeton A,Fitzmaurice AE

    更新日期:2001-02-01 00:00:00

  • Will shared decision making between patients with chronic musculoskeletal pain and physiotherapists, osteopaths and chiropractors improve patient care?

    abstract:BACKGROUND:Chronic musculoskeletal pain (CMP) is treated in primary care by a wide range of health professionals including chiropractors, osteopaths and physiotherapists. AIMS:To explore patients and chiropractors, osteopaths and physiotherapists' beliefs about CMP and its treatment and how these beliefs influenced ca...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmr083

    authors: Parsons S,Harding G,Breen A,Foster N,Pincus T,Vogel S,Underwood M

    更新日期:2012-04-01 00:00:00

  • The influence of a desk-top analyser on the number of laboratory tests used in daily general practice. A randomized controlled trial.

    abstract::This study evaluated the influence of a desk-top analyser, used in general practice, on the mean number of blood tests per contact, prescribed or analysed by general practitioners. A randomized controlled trial was used. The mean number of blood tests per contact requested by two groups of GPs, before and after the in...

    journal_title:Family practice

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/fampra/10.2.118

    authors: Gilio C,Buntinx F,De Kezel O,Scheys I

    更新日期:1993-06-01 00:00:00

  • Characteristics and perceptions of after-hours callers.

    abstract::After-hours care remains an important aspect of community practice although little is known about the views of either physicians or patients. This study presents an analysis of 12 499 after-hours calls made to a family practice centre over a five-year period, and 798 follow-up telephone interviews conducted with peopl...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/2.1.10

    authors: Evens S,Curtis P,Talbot A,Baer C,Smart A

    更新日期:1985-03-01 00:00:00

  • Classification of severity of health problems in family/general practice: an international field trial.

    abstract:BACKGROUND:A methodology is needed for classification of health problems by severity. OBJECTIVES:We aimed to test the Duke Severity of Illness Checklist (DUSOI) for feasibility and usefulness. METHOD:The DUSOI was field tested internationally by 22 family/general practitioners in 9 countries. RESULTS:The DUSOI was f...

    journal_title:Family practice

    pub_type: 杂志文章,多中心研究

    doi:10.1093/fampra/13.3.303

    authors: Parkerson GR Jr,Bridges-Webb C,Gervas J,Hofmans-Okkes I,Lamberts H,Froom J,Fischer G,Meyboom-de Jong B,Bentsen B,Klinkman M,de Maeseneer J

    更新日期:1996-06-01 00:00:00

  • Nutrition guidance in The Netherlands: the role of the GP in the translation from population strategy to individual approach.

    abstract::An important pitfall of nutritional guidance in medical practice is how to deal with the prevention paradox: a nutritional advice that is good for the population as a whole is not necessarily proven effective for the individual patient. Evidence-based guidelines are needed to support GPs to translate these advices to ...

    journal_title:Family practice

    pub_type: 杂志文章,评审

    doi:10.1093/fampra/cmn074

    authors: Drenthen AJ,Van Binsbergen JJ

    更新日期:2008-12-01 00:00:00

  • Ankle-brachial index measured by palpation for the diagnosis of peripheral arterial disease.

    abstract:BACKGROUND:The ankle-brachial index (ABI), i.e. the ratio of the ankle to brachial systolic blood pressure, is the golden standard for the diagnosis of peripheral arterial disease (PAD) and is a highly specific method for the assessment of vascular risk in otherwise asymptomatic patients. OBJECTIVE:To assess the diagn...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmn035

    authors: Migliacci R,Nasorri R,Ricciarini P,Gresele P

    更新日期:2008-08-01 00:00:00

  • Multimorbidity patterns in a primary care population aged 55 years and over.

    abstract:BACKGROUND:To support the management of multimorbid patients in primary care, evidence is needed on prevalent multimorbidity patterns. OBJECTIVE:To identify the common and distinctive multimorbidity patterns. METHODS:Clinical data of 120480 patients (≥55 years) were extracted from 158 general practices in 2002-11. Pr...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmv037

    authors: Sinnige J,Korevaar JC,Westert GP,Spreeuwenberg P,Schellevis FG,Braspenning JC

    更新日期:2015-10-01 00:00:00

  • Validation of self-reported help-seeking, and measurement of the patient interval, for cancer symptoms: an observational study to inform methodological challenges in symptomatic presentation research.

    abstract:BACKGROUND:To improve earlier presentation with potential symptoms of cancer, accurate data are needed on how people respond to these symptoms. It is currently unclear how self-reported medical help-seeking for symptoms associated with cancer by people from the community correspond to what is recorded in their general ...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/cmz047

    authors: Smith SM,Whitaker KL,Cardy AH,Elliott AM,Hannaford PC,Murchie P

    更新日期:2020-02-19 00:00:00

  • The impact of a mass communications campaign on the reported management of asthma by general practitioners.

    abstract::There have been recent campaigns in many countries to address the increasing morbidity and mortality of asthma by promoting better management. This study aimed to evaluate the National Asthma Campaign (NAC), in Australia, and to assess the extent of its impact on reported asthma management. It was a cross-sectional, b...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/10.3.263

    authors: Tse M,Bridges-Webb C,Bauman A

    更新日期:1993-09-01 00:00:00

  • Why do mothers consult when their children cough?

    abstract::Mothers' beliefs and evaluations of their child's illness were studied in a group of 30 mothers who had consulted a general practitioner because of a cough. Data were collected by tape-recorded semi-structured interviews conducted in their own homes. A major concern for mothers was their fear that their child was goin...

    journal_title:Family practice

    pub_type: 杂志文章

    doi:10.1093/fampra/10.2.193

    authors: Cornford CS,Morgan M,Ridsdale L

    更新日期:1993-06-01 00:00:00

  • How can adherence to lipid-lowering medication be improved? A systematic review of randomized controlled trials.

    abstract:OBJECTIVE:Poor patient adherence to lipid-lowering medication is a major contributory factor in the lack of success in treating hyperlipidaemia. The objective of this review was to assess the effect of adherence-enhancing interventions for lipid-lowering medication. DESIGN:Systematic review of randomized controlled tr...

    journal_title:Family practice

    pub_type: 杂志文章,评审

    doi:10.1093/fampra/cmm030

    authors: Schedlbauer A,Schroeder K,Fahey T

    更新日期:2007-09-01 00:00:00