Maxillary sinusitis in adults: an evaluation of placebo-controlled double-blind trials.

Abstract:

BACKGROUND:In general practice, acute sinusitis is frequently diagnosed and treated with antibiotics. OBJECTIVE:This study aimed to determine the evidence for the effectiveness of antibiotic treatment in acute maxillary sinusitis in adults by assessing the methodological quality of placebo-controlled double-blind randomized trials. METHOD:An evaluation by four raters through a 35-item scoring-scale for internal and external validity of all placebo-controlled double-blind randomized trials on acute sinusitis found between January 1966 and July 1996. RESULTS:Eighty-five trials were excluded because they were not placebo-controlled, double-blind, randomized, or were carried out in patients with chronic sinusitis or in children. The three remaining trials were performed in different populations (one in general practice) between 1973 and 1978. Only one study claimed superiority of antibiotic treatment. Different inclusion criteria and major outcome measures were used by the authors. The reliability of major outcome events was reported poorly or not at all and in two studies outcome measures were clinically inappropriate. The studies scored 30-62% of the maximum attainable score for internal validity and 10-20% for external validity. CONCLUSION:The effectiveness of antibiotic treatment in acute maxillary sinusitis in a general practice population is not based sufficiently on evidence.

journal_name

Fam Pract

journal_title

Family practice

authors

Stalman W,van Essen GA,van der Graaf Y,de Melker RA

doi

10.1093/fampra/14.2.124

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

124-9

issue

2

eissn

0263-2136

issn

1460-2229

journal_volume

14

pub_type

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