Abstract:
BACKGROUND:In general practice, acute sinusitis is frequently diagnosed and treated with antibiotics. OBJECTIVE:This study aimed to determine the evidence for the effectiveness of antibiotic treatment in acute maxillary sinusitis in adults by assessing the methodological quality of placebo-controlled double-blind randomized trials. METHOD:An evaluation by four raters through a 35-item scoring-scale for internal and external validity of all placebo-controlled double-blind randomized trials on acute sinusitis found between January 1966 and July 1996. RESULTS:Eighty-five trials were excluded because they were not placebo-controlled, double-blind, randomized, or were carried out in patients with chronic sinusitis or in children. The three remaining trials were performed in different populations (one in general practice) between 1973 and 1978. Only one study claimed superiority of antibiotic treatment. Different inclusion criteria and major outcome measures were used by the authors. The reliability of major outcome events was reported poorly or not at all and in two studies outcome measures were clinically inappropriate. The studies scored 30-62% of the maximum attainable score for internal validity and 10-20% for external validity. CONCLUSION:The effectiveness of antibiotic treatment in acute maxillary sinusitis in a general practice population is not based sufficiently on evidence.
journal_name
Fam Practjournal_title
Family practiceauthors
Stalman W,van Essen GA,van der Graaf Y,de Melker RAdoi
10.1093/fampra/14.2.124subject
Has Abstractpub_date
1997-04-01 00:00:00pages
124-9issue
2eissn
0263-2136issn
1460-2229journal_volume
14pub_type
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