Abstract:
:This study aimed to isolate quercetin (for the first time) from Anabaena aequalis Borge, which inhabits soil surface of Wadi El-Alaqui Protectorate located in Aswan city, Egypt. The isolated compound showed significant antibacterial activity against the gram-positive bacteria Sarcina maxima and Micrococcus kristinae, the gram-negative bacterium Klebsiella pneumoniae, as well as against the filamentous fungus Aspergillus flavus. The isolated compound was identified as quercetin using the structure elucidation based on UV, electrospray ionization mass spectrometry (ESIMS), (1) H and (13) C NMR, proton-proton correlation spectroscopy ((1) H-(1) H COSY), distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlations spectrum (HMBC). Medium lethal dose (LD50 ) of the isolated compound and its side effects against hyperlipidemia induced by ethanol intake in albino rats were carried out. No deaths were reported in rats within 72 h, which suggests that the isolated compound plays a beneficial role as an antihyperlipidemic agent in the treatment of alcohol-induced hepatic tissue damage, which can be described as one of the therapeutic values.
journal_name
J Phycoljournal_title
Journal of phycologyauthors
Abdel-Raouf N,Ibraheem IB,Abdel-Tawab S,Naser YAdoi
10.1111/j.1529-8817.2011.01020.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
955-62issue
4eissn
0022-3646issn
1529-8817journal_volume
47pub_type
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