Abstract：
:In this study, the newly synthesized non-centrosymmetric, 4-dimethylamino-3'-isothiocyanatochalcone (PKA) compound was presented. This compound belongs to the chalcone group, and its main purpose is to be used in biomedical imaging as a fluorescence dye. For this reason, the linear and nonlinear properties in solvents of different polarity were thoroughly studied. In accordance with the requirements for a fluorochrome, the PKA compound is characterized by strong absorption, large Stokes' shifts, relatively high fluorescence quantum yields and high nonlinear optical response. Moreover, the isothiocyanate reactive probe was conjugated with Concanavalin A. Conventional fluorescence microscopy imaging of Candida albicans cells incubated with the PKA-Concanavalin A, is presented. The results of this study show that the novel conjugate PKA-Concanavalin A could be a promising new probe for cellular labelling in biological and biomedical research. Graphical abstract Spectroscopic behavior of the PKA dye.
journal_name
J Mol Modeljournal_title
Journal of molecular modelingauthors
Krawczyk P,Pietrzak M,Janek T,Jędrzejewska B,Cysewski Pdoi
10.1007/s00894-016-2990-4subject
Has Abstractpub_date
2016-06-01 00:00:00pages
125issue
6eissn
1610-2940issn
0948-5023pii
10.1007/s00894-016-2990-4journal_volume
22pub_type
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