Abstract：
:Xenotransplantation could provide an unlimited supply of organs and solve the current shortage of organs for transplantation. To become a reality in clinical practice, the immunological and physiological barriers and the risk of xenozoonosis that they possess should be resolved. From the immunological point of view, in the last 30 years a significant progress in the production of transgenic pigs has prevented the hyperacute rejection. About xenozoonosis, attention has been focused on the risk of transmission of porcine endogenous retroviruses; however, today, it is considered that the risk is very low and the inevitable transmission should not prevent the clinical xenotransplantation. Regarding the physiological barriers, encouraging results have been obtained and it's expected that the barriers that still need to be corrected can be solved in the future through genetic modifications.
journal_name
Cir Espjournal_title
Cirugia espanolaauthors
Aristizabal AM,Caicedo LA,Martínez JM,Moreno M,J Echeverri Gdoi
10.1016/j.ciresp.2016.12.008subject
Has Abstractpub_date
2017-02-01 00:00:00pages
62-72issue
2eissn
0009-739Xissn
1578-147Xpii
S0009-739X(16)30221-4journal_volume
95pub_type
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