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Influence of aortic valve leaflet calcification on dynamic aortic valve motion assessed by cardiac computed tomography.

Abstract：

BACKGROUND:Computed tomography is the best noninvasive imaging modality for evaluating valve leaflet calcification. OBJECTIVE:To evaluate the association of aortic valve leaflet calcification with instantaneous valve opening and closing using dynamic multidetector computed tomography (MDCT). METHODS:We retrospectively evaluated 58 consecutive patients who underwent dynamic MDCT imaging. Aortic valve calcification (AVC) was quantified using the Agatston method. The aortic valve area (AVA) tracking curves were derived by planimetry during the cardiac cycle using all 20 phases (5% reconstruction). da/dt in cm2/s was calculated as the rate of change of AVA during opening (positive) or closing (negative). Patients were divided into 3 three groups according to Agatston score quartile: no AVC (Q2, Score 0, n = 18), mild AVC (Q3, Score 1-2254, n = 24), and severe AVC (Q4 Score >2254, n = 14). RESULTS:In multivariable linear regression, compared to the non AVC group, the mild and severe AVC groups had lower maximum AVA (by -1.71 cm2 and -2.25 cm2, respectively), lower peak positive da/dt (by -21.88 cm2/s and -26.65 cm2/s, respectively), and higher peak negative da/dt (by 13.78 cm2/s and 18.11 cm2/s, respectively) (p < 0.05 for all comparisons). CONCLUSIONS:AVA and its opening and closing were influenced by leaflet calcification. The present study demonstrates the ability of dynamic MDCT imaging to assess quantitative aortic valve motion in a clinical setting.

journal_name

J Cardiovasc Comput Tomogr

journal_title

Journal of cardiovascular computed tomography

authors

Minami K,Yoneyama K,Izumo M,Suzuki K,Ogawa Y,Chikaraishi K,Ogawa Y,Kobayashi Y,Furukawa T,Tanabe Y,Akashi YJ

doi

10.1016/j.jcct.2016.08.006

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

485-490

issue

6

eissn

1934-5925

issn

1876-861X

pii

S1934-5925(16)30187-3

journal_volume

10

pub_type

杂志文章

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