Understanding the Role of P Values and Hypothesis Tests in Clinical Research.

abstract：Importance:Computed tomography-derived fractional flow reserve (FFR-CT) is a novel, noninvasive test for myocardial ischemia. Clinicians using FFR-CT must be able to interpret individual FFR-CT results to determine subsequent patient care. Objective:To provide clinicians a means of interpreting individual FFR-CT resul...

journal_title：JAMA cardiology

authors： Cook CM,Petraco R,Shun-Shin MJ,Ahmad Y,Nijjer S,Al-Lamee R,Kikuta Y,Shiono Y,Mayet J,Francis DP,Sen S,Davies JE

更新日期：2017-07-01 00:00:00

abstract：Importance:Accurate, real-time case identification is needed to target interventions to improve quality and outcomes for hospitalized patients with heart failure. Problem lists may be useful for case identification but are often inaccurate or incomplete. Machine-learning approaches may improve accuracy of identificatio...

journal_title：JAMA cardiology

authors： Blecker S,Katz SD,Horwitz LI,Kuperman G,Park H,Gold A,Sontag D

更新日期：2016-12-01 00:00:00

abstract：Importance:Low-density lipoprotein cholesterol (LDL-C)-lowering therapies are a cornerstone of prevention in atherosclerotic cardiovascular disease. With the introduction of generic formulations and the release of new therapies, including proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, contemporary Me...

journal_title：JAMA cardiology

authors： Sumarsono A,Lalani HS,Vaduganathan M,Navar AM,Fonarow GC,Das SR,Pandey A

更新日期：2021-01-01 00:00:00

abstract：Importance:In clinical trials, transcatheter aortic valve replacement (TAVR) has been shown to improve symptoms and quality of life. As this technology moves into general clinical practice, evaluation of the health status outcomes among unselected patients treated with TAVR is of critical importance. Objective:To exam...

journal_title：JAMA cardiology

authors： Arnold SV,Spertus JA,Vemulapalli S,Li Z,Matsouaka RA,Baron SJ,Vora AN,Mack MJ,Reynolds MR,Rumsfeld JS,Cohen DJ

更新日期：2017-04-01 00:00:00

abstract：Importance:After a period of rapid growth, use of cardiac stress testing has recently decreased among Medicare beneficiaries and in a large integrated health system. However, it is not known whether declines in cardiac stress testing are universal or are confined to certain populations. Objective:To determine trends i...

journal_title：JAMA cardiology

authors： Kini V,McCarthy FH,Dayoub E,Bradley SM,Masoudi FA,Ho PM,Groeneveld PW

更新日期：2016-12-01 00:00:00

abstract：Importance:Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective:To quantify and describe levels and tren...

journal_title：JAMA cardiology

authors： Global Burden of Cardiovascular Diseases Collaboration.,Roth GA,Johnson CO,Abate KH,Abd-Allah F,Ahmed M,Alam K,Alam T,Alvis-Guzman N,Ansari H,Ärnlöv J,Atey TM,Awasthi A,Awoke T,Barac A,Bärnighausen T,Bedi N,Bennett D,

更新日期：2018-05-01 00:00:00

abstract：Importance:Little is known about the influence of comprehensive public health initiatives according to out-of-hospital cardiac arrest (OHCA) location, particularly at home, where resuscitation efforts and outcomes have historically been poor. Objective:To describe temporal trends in bystander cardiopulmonary resuscita...

journal_title：JAMA cardiology

authors： Fordyce CB,Hansen CM,Kragholm K,Dupre ME,Jollis JG,Roettig ML,Becker LB,Hansen SM,Hinohara TT,Corbett CC,Monk L,Nelson RD,Pearson DA,Tyson C,van Diepen S,Anderson ML,McNally B,Granger CB

更新日期：2017-11-01 00:00:00

abstract：Importance:Persons with human immunodeficiency virus (HIV) that is treated with antiretroviral therapy have improved longevity but face an elevated risk of myocardial infarction (MI) due to common MI risk factors and HIV-specific factors. Despite these elevated MI rates, optimal methods to predict MI risks for HIV-infe...

journal_title：JAMA cardiology

authors： Feinstein MJ,Nance RM,Drozd DR,Ning H,Delaney JA,Heckbert SR,Budoff MJ,Mathews WC,Kitahata MM,Saag MS,Eron JJ,Moore RD,Achenbach CJ,Lloyd-Jones DM,Crane HM

更新日期：2017-02-01 00:00:00

abstract：Importance:Physicians have been criticized for having an overly enthusiastic response to new device approvals, especially for novel technologies. However, to our knowledge, the rates of new product adoption and patterns of new device usage in clinical practice have not been well described. Objective:To characterize th...

journal_title：JAMA cardiology

authors： Chau KH,Kennedy KF,Messenger JC,Garratt KN,Maddox TM,Yeh RW,Kirtane AJ

更新日期：2019-06-01 00:00:00

abstract：Importance:Somatic mutations causing clonal expansion of hematopoietic cells (clonal hematopoiesis of indeterminate potential [CHIP]) are increased with age and associated with atherosclerosis and inflammation. Age and inflammation are the major risk factors for heart failure, yet the association of CHIP with heart fai...

journal_title：JAMA cardiology

authors： Dorsheimer L,Assmus B,Rasper T,Ortmann CA,Ecke A,Abou-El-Ardat K,Schmid T,Brüne B,Wagner S,Serve H,Hoffmann J,Seeger F,Dimmeler S,Zeiher AM,Rieger MA

更新日期：2019-01-01 00:00:00

abstract：Importance:Depression is increasingly recognized as a risk factor for adverse outcomes in cardiovascular disease. However, little is known about depression in older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement. Objective:To determine the prevalence of depression and its associatio...

journal_title：JAMA cardiology

authors： Drudi LM,Ades M,Turkdogan S,Huynh C,Lauck S,Webb JG,Piazza N,Martucci G,Langlois Y,Perrault LP,Asgar AW,Labinaz M,Lamy A,Noiseux N,Peterson MD,Arora RC,Lindman BR,Bendayan M,Mancini R,Trnkus A,Kim DH,Popma JJ,

更新日期：2018-03-01 00:00:00

abstract：Importance:Cardiac dysfunction is a leading cause of morbidity and mortality in Duchenne muscular dystrophy (DMD). This case highlights the importance of steroids in treating cardiac complications of DMD and the dangers of discontinuing or switching between steroid classes. Objective:To recognize the presentation of a...

journal_title：JAMA cardiology

authors： Abutaleb ARA,McNally EM,Khan SS,Anderson AS,Carr JC,Wilcox JE

更新日期：2018-10-01 00:00:00

abstract：Importance:Limited evidence is available regarding the benefit and hazard of higher-intensity treatment to lower lipid levels among patients 75 years or older. As a result, guideline recommendations differ for this age group compared with younger patients. Objective:To determine the effect on outcomes and risks of com...

journal_title：JAMA cardiology

authors： Bach RG,Cannon CP,Giugliano RP,White JA,Lokhnygina Y,Bohula EA,Califf RM,Braunwald E,Blazing MA

更新日期：2019-09-01 00:00:00

abstract：Importance:Despite considerable improvements in heart failure care, mortality rates among patients in high-income countries have changed little since the early 2000s. Understanding the reasons underlying these trends may provide valuable clues for developing more targeted therapies and public health strategies. Object...

journal_title：JAMA cardiology

authors： Conrad N,Judge A,Canoy D,Tran J,Pinho-Gomes AC,Millett ERC,Salimi-Khorshidi G,Cleland JG,McMurray JJV,Rahimi K

更新日期：2019-11-01 00:00:00

abstract：Importance:Cardiac stress testing is often performed prior to noncardiac surgery, although trends in use of preoperative stress testing and the effect of testing on cardiovascular outcomes are currently unknown. Objective:To describe temporal trends and outcomes of preoperative cardiac stress testing from 2004 to 2017...

journal_title：JAMA cardiology

authors： Rubin DS,Hughey R,Gerlach RM,Ham SA,Ward RP,Nagele P

更新日期：2021-01-01 00:00:00

abstract：Importance:Women are at higher risk of drug-induced torsade de pointes (TdP) than men. Androgens are protective. Influence of oral contraception on drug-induced TdP and QT prolongation is controversial. Objective:To determine if the extent of sotalol-induced corrected QT (QTc) prolongation and specific T-wave morpholo...

journal_title：JAMA cardiology

authors： Salem JE,Dureau P,Bachelot A,Germain M,Voiriot P,Lebourgeois B,Trégouët DA,Hulot JS,Funck-Brentano C

更新日期：2018-09-01 00:00:00

abstract：Importance:Myocardial replacement fibrosis has been reported to occur in one-third of patients with mitral valve prolapse (MVP) and significant mitral regurgitation (MR). However, it remains unknown whether there are detectable changes in myocardial metabolism suggestive of inflammation or ischemia that accompany the d...

journal_title：JAMA cardiology

authors： Miller MA,Adams DH,Pandis D,Robson PM,Pawale A,Pyzik R,Liao SL,El-Eshmawi A,Boateng P,Garg J,Waterford S,Weiner MM,Dukkipati SR,Reddy VY,Fayad ZA,Trivieri MG

更新日期：2020-09-01 00:00:00

abstract：IMPORTANCE:Reduced rates of cardiac catheterization, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) are an unintended consequence of public reporting of cardiogenic shock outcomes in New York. OBJECTIVES:To evaluate whether the referral rates for cardiac catheterization, PCI, or CABG...

journal_title：JAMA cardiology

authors： Bangalore S,Guo Y,Xu J,Blecker S,Gupta N,Feit F,Hochman JS

更新日期：2016-09-01 00:00:00

abstract：Importance:Transthyretin cardiac amyloidosis (also known as ATTR cardiac amyloidosis) is an increasingly recognized cause of heart failure with preserved ejection fraction. In single-center studies, technetium 99m pyrophosphate (Tc 99m PYP) cardiac imaging noninvasively detects ATTR cardiac amyloidosis, but the accurac...

journal_title：JAMA cardiology

authors： Castano A,Haq M,Narotsky DL,Goldsmith J,Weinberg RL,Morgenstern R,Pozniakoff T,Ruberg FL,Miller EJ,Berk JL,Dispenzieri A,Grogan M,Johnson G,Bokhari S,Maurer MS

更新日期：2016-11-01 00:00:00

abstract：Importance:Cardiac resynchronization therapy (CRT) provides significant reduction in morbidity and mortality in select patients with left ventricular systolic dysfunction and specific parameters of electrocardiographic evidence of dyssynchrony. Relative to the 2012 American College of Cardiology/American Heart Associat...

journal_title：JAMA cardiology

authors： Sandhu A,Bao H,Minges KE,Varosy PD,Borne RT,Zipse MM,Marzec L,Peterson P,Masoudi F,Bradley SM

更新日期：2019-08-01 00:00:00

abstract：Importance:There are major gaps in use of guideline-directed medical therapy (GDMT) for patients with heart failure (HF). Patient-reported data outlining patient goals and preferences associated with GDMT are not available. Objective:To survey patients with chronic HF to better understand their experiences and percept...

journal_title：JAMA cardiology

authors： Samsky MD,Lin L,Greene SJ,Lippmann SJ,Peterson PN,Heidenreich PA,Laskey WK,Yancy CW,Greiner MA,Hardy NC,Kavati A,Park S,Mentz RJ,Fonarow GC,O'Brien EC

更新日期：2020-03-01 00:00:00

abstract：Importance:Hospitalizations for worsening heart failure (WHF) represent an enormous public health and financial burden, with physicians, health systems, and payers placing increasing emphasis on hospitalization prevention. In addition, maximizing time out of the hospital is an important patient-centered outcome. In thi...

journal_title：JAMA cardiology

authors： Greene SJ,Mentz RJ,Felker GM

更新日期：2018-03-01 00:00:00

abstract：Importance:The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. Objective:To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Gl...

journal_title：JAMA cardiology

authors： Lam CSP,Giczewska A,Sliwa K,Edelmann F,Refsgaard J,Bocchi E,Ezekowitz JA,Hernandez AF,O'Connor CM,Roessig L,Patel MJ,Pieske B,Anstrom KJ,Armstrong PW,VICTORIA Study Group.

更新日期：2020-11-13 00:00:00

abstract：Importance:Low-density lipoprotein cholesterol (LDL-C) is an important modifiable risk factor for atherosclerotic cardiovascular disease. It is unclear whether the percentage LDL-C lowering with pharmacotherapies differs on the basis of baseline LDL-C levels. Objective:To evaluate the association between baseline LDL-...

journal_title：JAMA cardiology

authors： Marcusa DP,Giugliano RP,Park JG,de Lemos JA,Cannon CP,Sabatine MS

更新日期：2020-11-13 00:00:00

abstract：Importance:Observational studies have reported an association between low serum vitamin D levels and elevated risk of cardiovascular disease (CVD) events, but such studies cannot prove causation because of possible unmeasured confounding. Objective:We conducted a meta-analysis of randomized clinical trials that tested...

journal_title：JAMA cardiology

authors： Barbarawi M,Kheiri B,Zayed Y,Barbarawi O,Dhillon H,Swaid B,Yelangi A,Sundus S,Bachuwa G,Alkotob ML,Manson JE

更新日期：2019-08-01 00:00:00

abstract：Importance:Strategies for reliable selection of high-risk patients with hypertrophic cardiomyopathy (HCM) for prevention of sudden cardiac death (SCD) with implantable cardioverter/defibrillators (ICDs) are incompletely resolved. Objective:To assess the reliability of SCD prediction methods leading to prophylactic ICD...

journal_title：JAMA cardiology

authors： Maron MS,Rowin EJ,Wessler BS,Mooney PJ,Fatima A,Patel P,Koethe BC,Romashko M,Link MS,Maron BJ

更新日期：2019-07-01 00:00:00

abstract：Importance:The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated the benefit of lowering systolic blood pressure (SBP) to 120 mm Hg, yet other trials, such as Heart Outcomes Prevention Evaluation-3 (HOPE-3), did not find consistent benefit. How to incorporate these results into the treatment of those wit...

journal_title：JAMA cardiology

authors： Navar AM,Pencina MJ,Peterson ED

更新日期：2016-11-01 00:00:00

abstract：Importance:It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective:To describe baseline characteristics of participants en...

journal_title：JAMA cardiology

authors： Hochman JS,Reynolds HR,Bangalore S,O'Brien SM,Alexander KP,Senior R,Boden WE,Stone GW,Goodman SG,Lopes RD,Lopez-Sendon J,White HD,Maggioni AP,Shaw LJ,Min JK,Picard MH,Berman DS,Chaitman BR,Mark DB,Spertus JA,Cyr D

更新日期：2019-03-01 00:00:00

abstract：Importance:Many of the quality measures used to assess accountable care organization (ACO) performance in the Medicare Shared Savings Program (MSSP) focus on disease control and medication use among patients with cardiovascular disease and diabetes. To date, the association between participation in the MSSP by provider...

journal_title：JAMA cardiology

authors： McWilliams JM,Najafzadeh M,Shrank WH,Polinski JM

更新日期：2017-09-01 00:00:00

abstract：Importance:If we assume that women and men exhibit variations of the same fundamental vascular physiology, then conventional analyses of subclinical measures would suggest that women catch up to men by midlife in the extent of potentially important vascular disease. Alternatively, under the assumption that vascular phy...

journal_title：JAMA cardiology

authors： Ji H,Kim A,Ebinger JE,Niiranen TJ,Claggett BL,Bairey Merz CN,Cheng S

更新日期：2020-03-01 00:00:00