Cardiac Stress Test Trends Among US Patients Younger Than 65 Years, 2005-2012.

Abstract:

Importance:After a period of rapid growth, use of cardiac stress testing has recently decreased among Medicare beneficiaries and in a large integrated health system. However, it is not known whether declines in cardiac stress testing are universal or are confined to certain populations. Objective:To determine trends in rates of cardiac stress testing among a large and diverse cohort of commercially insured patients. Design, Setting, and Participants:A serial cross-sectional study with time trends was conducted using administrative claims from all members aged 25 to 64 years belonging to a large, national managed care company from January 1, 2005, to December 31, 2012. Linear trends in rates were determined using negative binomial regression models with procedure count as the dependent variable, calendar quarter as the key independent variable, and the size of the population as a logged offset term. Data analysis was performed from January 1, 2005, to December 31, 2012. Main Outcomes and Measures:Age- and sex-adjusted rates of cardiac stress tests per calendar quarter (reported as number of tests per 100 000 person-years). Results:A total of 2 085 591 cardiac stress tests were performed among 32 921 838 persons (mean [SD] age, 43.2 [10.9] years; 16 625 528 women [50.5%] and 16 296 310 [49.5%] men; 7 604 945 nonwhite [23.1%]). There was a 3.0% increase in rates of cardiac stress testing from 2005 (3486 tests; 95% CI, 3458-3514) to 2012 (3589 tests; 95% CI, 3559-3619; P = .01 for linear trend). Use of nuclear single-photon emission computed tomography decreased by 14.9% from 2005 (1907 tests; 95% CI, 1888-1926) to 2012 (1623 tests; 95% CI, 1603-1643; P = .03). Use of stress echocardiography increased by 27.8% from 2005 (709 tests; 95% CI, 697-721) to 2012 (906 tests; 95% CI, 894 to 920; P < .001). Use of exercise electrocardiography increased by 12.5% from 2005 (861 tests; 95% CI, 847-873) to 2012 (969 tests; 95% CI, 953-985; P < .001). Use of other stress testing modalities increased 65.5% from 2006 (55 tests; 95% CI, 51-59) to 2012 (91 tests; 95% CI, 87-95; P < .001). For individuals aged 25 to 34 years, rates of cardiac stress testing increased 59.1% from 2005 (543 tests; 95% CI, 532-554) to 2012 (864 tests; 95% CI, 852-876; P < .001). For individuals aged 55 to 64 years, rates of cardiac stress testing decreased by 12.3% from 2005 (7894 tests; 95% CI, 7820-7968) to 2012 (6923 tests; 95% CI, 6853-6993; P < .001). Conclusions and Relevance:In contrast to declines in the use of cardiac stress testing in some health care systems, we observed a small increase in its use among a nationally representative cohort of commercially insured patients. Our findings suggest that observed trends in the use of cardiac stress testing may have been driven more by unique characteristics of populations and health systems than national efforts to reduce the overuse of testing.

journal_name

JAMA Cardiol

journal_title

JAMA cardiology

authors

Kini V,McCarthy FH,Dayoub E,Bradley SM,Masoudi FA,Ho PM,Groeneveld PW

doi

10.1001/jamacardio.2016.3153

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1038-1042

issue

9

eissn

2380-6583

issn

2380-6591

pii

2583458

journal_volume

1

pub_type

杂志文章
  • Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the PARTNER Trial.

    abstract:Importance:Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective:To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Set...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamacardio.2017.3306

    authors: Douglas PS,Leon MB,Mack MJ,Svensson LG,Webb JG,Hahn RT,Pibarot P,Weissman NJ,Miller DC,Kapadia S,Herrmann HC,Kodali SK,Makkar RR,Thourani VH,Lerakis S,Lowry AM,Rajeswaran J,Finn MT,Alu MC,Smith CR,Blackstone EH,

    更新日期:2017-11-01 00:00:00

  • Association of Echocardiographic Left Ventricular End-Systolic Volume and Volume-Derived Ejection Fraction With Outcome in Asymptomatic Chronic Aortic Regurgitation.

    abstract:Importance:Volumetric measurements by transthoracic echocardiogram may better reflect left ventricular (LV) remodeling than conventional linear LV dimensions. However, the association of LV volumes with mortality in patients with chronic hemodynamically significant aortic regurgitation (AR) is unknown. Objective:To as...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2020.5268

    authors: Yang LT,Anand V,Zambito EI,Pellikka PA,Scott CG,Thapa P,Padang R,Takeuchi M,Nishimura RA,Enriquez-Sarano M,Michelena HI

    更新日期:2020-11-04 00:00:00

  • Uptake of Drug-Eluting Bioresorbable Vascular Scaffolds in Clinical Practice: An NCDR Registry to Practice Project.

    abstract:Importance:Physicians have been criticized for having an overly enthusiastic response to new device approvals, especially for novel technologies. However, to our knowledge, the rates of new product adoption and patterns of new device usage in clinical practice have not been well described. Objective:To characterize th...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.0388

    authors: Chau KH,Kennedy KF,Messenger JC,Garratt KN,Maddox TM,Yeh RW,Kirtane AJ

    更新日期:2019-06-01 00:00:00

  • Trends in Utilization and Cost of Low-Density Lipoprotein Cholesterol-Lowering Therapies Among Medicare Beneficiaries: An Analysis From the Medicare Part D Database.

    abstract:Importance:Low-density lipoprotein cholesterol (LDL-C)-lowering therapies are a cornerstone of prevention in atherosclerotic cardiovascular disease. With the introduction of generic formulations and the release of new therapies, including proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, contemporary Me...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2020.3723

    authors: Sumarsono A,Lalani HS,Vaduganathan M,Navar AM,Fonarow GC,Das SR,Pandey A

    更新日期:2021-01-01 00:00:00

  • Hybrid Positron Emission Tomography/Magnetic Resonance Imaging in Arrhythmic Mitral Valve Prolapse.

    abstract:Importance:Myocardial replacement fibrosis has been reported to occur in one-third of patients with mitral valve prolapse (MVP) and significant mitral regurgitation (MR). However, it remains unknown whether there are detectable changes in myocardial metabolism suggestive of inflammation or ischemia that accompany the d...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2020.1555

    authors: Miller MA,Adams DH,Pandis D,Robson PM,Pawale A,Pyzik R,Liao SL,El-Eshmawi A,Boateng P,Garg J,Waterford S,Weiner MM,Dukkipati SR,Reddy VY,Fayad ZA,Trivieri MG

    更新日期:2020-09-01 00:00:00

  • Quality-of-Life Outcomes After Transcatheter Aortic Valve Replacement in an Unselected Population: A Report From the STS/ACC Transcatheter Valve Therapy Registry.

    abstract:Importance:In clinical trials, transcatheter aortic valve replacement (TAVR) has been shown to improve symptoms and quality of life. As this technology moves into general clinical practice, evaluation of the health status outcomes among unselected patients treated with TAVR is of critical importance. Objective:To exam...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2016.5302

    authors: Arnold SV,Spertus JA,Vemulapalli S,Li Z,Matsouaka RA,Baron SJ,Vora AN,Mack MJ,Reynolds MR,Rumsfeld JS,Cohen DJ

    更新日期:2017-04-01 00:00:00

  • Prognostic Implications of Biomarker Assessments in Patients With Type 2 Diabetes at High Cardiovascular Risk: A Secondary Analysis of a Randomized Clinical Trial.

    abstract:Importance:Cardiac biomarkers provide insights into pathophysiologic processes and offer an attractive strategy for the assessment of cardiovascular risk. Objective:To assess the incremental prognostic value of biomarkers that reflect different pathophysiologic processes in patients with type 2 diabetes. Design, Sett...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.3030

    authors: Scirica BM,Bhatt DL,Braunwald E,Raz I,Cavender MA,Im K,Mosenzon O,Udell JA,Hirshberg B,Pollack PS,Steg PG,Jarolim P,Morrow DA

    更新日期:2016-12-01 00:00:00

  • Enhanced American College of Cardiology/American Heart Association Strategy for Prevention of Sudden Cardiac Death in High-Risk Patients With Hypertrophic Cardiomyopathy.

    abstract:Importance:Strategies for reliable selection of high-risk patients with hypertrophic cardiomyopathy (HCM) for prevention of sudden cardiac death (SCD) with implantable cardioverter/defibrillators (ICDs) are incompletely resolved. Objective:To assess the reliability of SCD prediction methods leading to prophylactic ICD...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.1391

    authors: Maron MS,Rowin EJ,Wessler BS,Mooney PJ,Fatima A,Patel P,Koethe BC,Romashko M,Link MS,Maron BJ

    更新日期:2019-07-01 00:00:00

  • Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study.

    abstract:Importance:With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection is associated with HF with reduc...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.0264

    authors: Freiberg MS,Chang CH,Skanderson M,Patterson OV,DuVall SL,Brandt CA,So-Armah KA,Vasan RS,Oursler KA,Gottdiener J,Gottlieb S,Leaf D,Rodriguez-Barradas M,Tracy RP,Gibert CL,Rimland D,Bedimo RJ,Brown ST,Goetz MB,Warner

    更新日期:2017-05-01 00:00:00

  • Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis.

    abstract:Importance:Transthyretin cardiac amyloidosis (also known as ATTR cardiac amyloidosis) is an increasingly recognized cause of heart failure with preserved ejection fraction. In single-center studies, technetium 99m pyrophosphate (Tc 99m PYP) cardiac imaging noninvasively detects ATTR cardiac amyloidosis, but the accurac...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2016.2839

    authors: Castano A,Haq M,Narotsky DL,Goldsmith J,Weinberg RL,Morgenstern R,Pozniakoff T,Ruberg FL,Miller EJ,Berk JL,Dispenzieri A,Grogan M,Johnson G,Bokhari S,Maurer MS

    更新日期:2016-11-01 00:00:00

  • Association of Transcatheter Mitral Valve Repair With Quality of Life Outcomes at 30 Days and 1 Year: Analysis of the Transcatheter Valve Therapy Registry.

    abstract:Importance:Improvements in symptoms, functional capacity, and quality of life are among the key goals of edge-to-edge transcatheter mitral valve repair (TMVR) for mitral regurgitation. Objective:To examine health status outcomes among patients undergoing TMVR in clinical practice and the factors associated with improv...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2018.3359

    authors: Arnold SV,Li Z,Vemulapalli S,Baron SJ,Mack MJ,Kosinski AS,Reynolds MR,Hermiller JB,Rumsfeld JS,Cohen DJ

    更新日期:2018-12-01 00:00:00

  • Sudden Cardiac Arrest Risk Assessment: Population Science and the Individual Risk Mandate.

    abstract:Importance:High-resolution stratification of risk of sudden cardiac arrest (SCA) in individual patients is a tool that is necessary for achieving effective and efficient application of data generated by population-based research. This concept is at the core of initiatives for merging cost effectiveness with maximized c...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,评审

    doi:10.1001/jamacardio.2017.0266

    authors: Myerburg RJ,Goldberger JJ

    更新日期:2017-06-01 00:00:00

  • The Burden of Cardiovascular Diseases Among US States, 1990-2016.

    abstract:Importance:Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective:To quantify and describe levels and tren...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2018.0385

    authors: Global Burden of Cardiovascular Diseases Collaboration.,Roth GA,Johnson CO,Abate KH,Abd-Allah F,Ahmed M,Alam K,Alam T,Alvis-Guzman N,Ansari H,Ärnlöv J,Atey TM,Awasthi A,Awoke T,Barac A,Bärnighausen T,Bedi N,Bennett D,

    更新日期:2018-05-01 00:00:00

  • Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life.

    abstract:Importance:Long-term blood pressure (BP) variability has emerged as a reproducible measure that is associated with heart failure independent of systemic BP. Visit-to-visit BP variability may be associated with the risk of heart failure early in the life course and thus may be reflected in subclinical alterations in car...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2020.0799

    authors: Nwabuo CC,Yano Y,Moreira HT,Appiah D,Vasconcellos HD,Aghaji QN,Viera A,Rana JS,Shah RV,Murthy VL,Allen NB,Schreiner PJ,Lloyd-Jones DM,Lima JAC

    更新日期:2020-07-01 00:00:00

  • Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women.

    abstract:Importance:Women are at higher risk of drug-induced torsade de pointes (TdP) than men. Androgens are protective. Influence of oral contraception on drug-induced TdP and QT prolongation is controversial. Objective:To determine if the extent of sotalol-induced corrected QT (QTc) prolongation and specific T-wave morpholo...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2018.2251

    authors: Salem JE,Dureau P,Bachelot A,Germain M,Voiriot P,Lebourgeois B,Trégouët DA,Hulot JS,Funck-Brentano C

    更新日期:2018-09-01 00:00:00

  • Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

    abstract:Importance:Transcatheter aortic valve replacement (TAVR) is an established alternative to surgery for patients with severe symptomatic aortic stenosis. Adjunctive antithrombotic therapy used to mitigate thrombotic risks in patients undergoing TAVR must be balanced against bleeding complications, since both are associat...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,评审

    doi:10.1001/jamacardio.2019.4367

    authors: Saito Y,Nazif T,Baumbach A,Tchétché D,Latib A,Kaple R,Forrest J,Prendergast B,Lansky A

    更新日期:2020-01-01 00:00:00

  • Contemporary Use and Trends in Unprotected Left Main Coronary Artery Percutaneous Coronary Intervention in the United States: An Analysis of the National Cardiovascular Data Registry Research to Practice Initiative.

    abstract:Importance:Recent data support percutaneous revascularization as an alternative to coronary artery bypass grafting in unprotected left main (ULM) coronary lesions. However, the relevance of these trials to current practice is unclear, as patterns and outcomes of ULM percutaneous coronary intervention (PCI) in contempor...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2018.4376

    authors: Valle JA,Tamez H,Abbott JD,Moussa ID,Messenger JC,Waldo SW,Kennedy KF,Masoudi FA,Yeh RW

    更新日期:2019-02-01 00:00:00

  • Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis.

    abstract:Importance:Observational studies have reported an association between low serum vitamin D levels and elevated risk of cardiovascular disease (CVD) events, but such studies cannot prove causation because of possible unmeasured confounding. Objective:We conducted a meta-analysis of randomized clinical trials that tested...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamacardio.2019.1870

    authors: Barbarawi M,Kheiri B,Zayed Y,Barbarawi O,Dhillon H,Swaid B,Yelangi A,Sundus S,Bachuwa G,Alkotob ML,Manson JE

    更新日期:2019-08-01 00:00:00

  • Patient Perceptions and Familiarity With Medical Therapy for Heart Failure.

    abstract:Importance:There are major gaps in use of guideline-directed medical therapy (GDMT) for patients with heart failure (HF). Patient-reported data outlining patient goals and preferences associated with GDMT are not available. Objective:To survey patients with chronic HF to better understand their experiences and percept...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.4987

    authors: Samsky MD,Lin L,Greene SJ,Lippmann SJ,Peterson PN,Heidenreich PA,Laskey WK,Yancy CW,Greiner MA,Hardy NC,Kavati A,Park S,Mentz RJ,Fonarow GC,O'Brien EC

    更新日期:2020-03-01 00:00:00

  • Temporal Trends and Patterns in Mortality After Incident Heart Failure: A Longitudinal Analysis of 86 000 Individuals.

    abstract:Importance:Despite considerable improvements in heart failure care, mortality rates among patients in high-income countries have changed little since the early 2000s. Understanding the reasons underlying these trends may provide valuable clues for developing more targeted therapies and public health strategies. Object...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.3593

    authors: Conrad N,Judge A,Canoy D,Tran J,Pinho-Gomes AC,Millett ERC,Salimi-Khorshidi G,Cleland JG,McMurray JJV,Rahimi K

    更新日期:2019-11-01 00:00:00

  • Outcomes of Care for Ischemic Heart Disease and Chronic Heart Failure in the Veterans Health Administration.

    abstract:Importance:The Department of Veterans Affairs (VA) operates a nationwide system of hospitals and hospital-affiliated clinics, providing health care to more than 2 million veterans with cardiovascular disease. While data permitting hospital comparisons of the outcomes of acute cardiovascular care (eg, myocardial infarct...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2018.1115

    authors: Groeneveld PW,Medvedeva EL,Walker L,Segal AG,Richardson DM,Epstein AJ

    更新日期:2018-07-01 00:00:00

  • Assessing Cardiovascular Risk to Guide Hypertension Diagnosis and Treatment.

    abstract:Importance:The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated the benefit of lowering systolic blood pressure (SBP) to 120 mm Hg, yet other trials, such as Heart Outcomes Prevention Evaluation-3 (HOPE-3), did not find consistent benefit. How to incorporate these results into the treatment of those wit...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.2861

    authors: Navar AM,Pencina MJ,Peterson ED

    更新日期:2016-11-01 00:00:00

  • Performance of Hospitals When Assessing Disease-Based Mortality Compared With Procedural Mortality for Patients With Acute Myocardial Infarction.

    abstract:Importance:Quality of percutaneous coronary intervention (PCI) is commonly assessed by risk-adjusted mortality. However, this metric may result in procedural risk aversion, especially for high-risk patients. Objective:To determine correlation and reclassification between hospital-level disease-specific mortality and P...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2020.0753

    authors: Nathan AS,Xiang Q,Wojdyla D,Khatana SAM,Dayoub EJ,Wadhera RK,Bhatt DL,Kolansky DM,Kirtane AJ,Rao SV,Yeh RW,Groeneveld PW,Wang TY,Giri J

    更新日期:2020-07-01 00:00:00

  • Differences in Management of Coronary Artery Disease in Patients With Medicare Advantage vs Traditional Fee-for-Service Medicare Among Cardiology Practices.

    abstract:Importance:One-third of Medicare beneficiaries are enrolled in Medicare Advantage (MA), Medicare's private plan option. Medicare Advantage incentivizes performance on evidence-based care, but limited information exists using reliable clinical data to determine whether this translates into better quality for patients wi...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.0007

    authors: Figueroa JF,Blumenthal DM,Feyman Y,Frakt AB,Turchin A,Doros G,Gao Q,Song Y,Joynt Maddox KE

    更新日期:2019-03-01 00:00:00

  • Association of Changes in Medication Use and Adherence With Accountable Care Organization Exposure in Patients With Cardiovascular Disease or Diabetes.

    abstract:Importance:Many of the quality measures used to assess accountable care organization (ACO) performance in the Medicare Shared Savings Program (MSSP) focus on disease control and medication use among patients with cardiovascular disease and diabetes. To date, the association between participation in the MSSP by provider...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.2172

    authors: McWilliams JM,Najafzadeh M,Shrank WH,Polinski JM

    更新日期:2017-09-01 00:00:00

  • Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.

    abstract:Importance:Somatic mutations causing clonal expansion of hematopoietic cells (clonal hematopoiesis of indeterminate potential [CHIP]) are increased with age and associated with atherosclerosis and inflammation. Age and inflammation are the major risk factors for heart failure, yet the association of CHIP with heart fai...

    journal_title:JAMA cardiology

    pub_type: 临床试验,杂志文章

    doi:10.1001/jamacardio.2018.3965

    authors: Dorsheimer L,Assmus B,Rasper T,Ortmann CA,Ecke A,Abou-El-Ardat K,Schmid T,Brüne B,Wagner S,Serve H,Hoffmann J,Seeger F,Dimmeler S,Zeiher AM,Rieger MA

    更新日期:2019-01-01 00:00:00

  • Racial Differences in Atrial Fibrillation-Related Cardiovascular Disease and Mortality: The Atherosclerosis Risk in Communities (ARIC) Study.

    abstract:IMPORTANCE:The adverse outcomes associated with atrial fibrillation (AF) have been studied in predominantly white cohorts. Racial differences in outcomes associated with AF merit continued investigation. OBJECTIVE:To evaluate the race-specific associations of AF with stroke, heart failure, coronary heart disease (CHD)...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.1025

    authors: Magnani JW,Norby FL,Agarwal SK,Soliman EZ,Chen LY,Loehr LR,Alonso A

    更新日期:2016-07-01 00:00:00

  • Association Between Reproductive Life Span and Incident Nonfatal Cardiovascular Disease: A Pooled Analysis of Individual Patient Data From 12 Studies.

    abstract:Importance:Early menarche and early menopause are associated with increased risk of cardiovascular disease (CVD) in midlife, but little is known about the association between reproductive life span and the risk of CVD. Objective:To investigate the association between the length of reproductive life span and risk of in...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2020.4105

    authors: Mishra SR,Chung HF,Waller M,Dobson AJ,Greenwood DC,Cade JE,Giles GG,Bruinsma F,Simonsen MK,Hardy R,Kuh D,Gold EB,Crawford SL,Derby CA,Matthews KA,Demakakos P,Lee JS,Mizunuma H,Hayashi K,Sievert LL,Brown DE,Sandi

    更新日期:2020-09-16 00:00:00

  • Resuscitation Practices Associated With Survival After In-Hospital Cardiac Arrest: A Nationwide Survey.

    abstract:IMPORTANCE:Although survival of patients with in-hospital cardiac arrest varies markedly among hospitals, specific resuscitation practices that distinguish sites with higher cardiac arrest survival rates remain unknown. OBJECTIVE:To identify resuscitation practices associated with higher rates of in-hospital cardiac a...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.0073

    authors: Chan PS,Krein SL,Tang F,Iwashyna TJ,Harrod M,Kennedy M,Lehrich J,Kronick S,Nallamothu BK,American Heart Association's Get With the Guidelines–Resuscitation Investigators.

    更新日期:2016-05-01 00:00:00

  • Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial.

    abstract:Importance:Sustained reductions in low-density lipoprotein cholesterol (LDL-C) with lipid-lowering therapies that require frequent dosing are reliant on patient adherence, and poor adherence is associated with worse clinical outcomes. Objective:To determine whether inclisiran, a small interfering RNA, reduces mean LDL...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamacardio.2019.3502

    authors: Ray KK,Stoekenbroek RM,Kallend D,Nishikido T,Leiter LA,Landmesser U,Wright RS,Wijngaard PLJ,Kastelein JJP

    更新日期:2019-11-01 00:00:00