Sudden Cardiac Arrest Risk Assessment: Population Science and the Individual Risk Mandate.

abstract：Importance:After a period of rapid growth, use of cardiac stress testing has recently decreased among Medicare beneficiaries and in a large integrated health system. However, it is not known whether declines in cardiac stress testing are universal or are confined to certain populations. Objective:To determine trends i...

journal_title：JAMA cardiology

authors： Kini V,McCarthy FH,Dayoub E,Bradley SM,Masoudi FA,Ho PM,Groeneveld PW

更新日期：2016-12-01 00:00:00

abstract：Importance:Transcatheter aortic valve replacement (TAVR) is an established alternative to surgery for patients with severe symptomatic aortic stenosis. Adjunctive antithrombotic therapy used to mitigate thrombotic risks in patients undergoing TAVR must be balanced against bleeding complications, since both are associat...

journal_title：JAMA cardiology

authors： Saito Y,Nazif T,Baumbach A,Tchétché D,Latib A,Kaple R,Forrest J,Prendergast B,Lansky A

更新日期：2020-01-01 00:00:00

abstract：Importance:Cohort studies have reported increased incidence of cardiovascular disease (CVD) among individuals with low vitamin D status. To date, randomized clinical trials of vitamin D supplementation have not found an effect, possibly because of using too low a dose of vitamin D. Objective:To examine whether monthly...

journal_title：JAMA cardiology

authors： Scragg R,Stewart AW,Waayer D,Lawes CMM,Toop L,Sluyter J,Murphy J,Khaw KT,Camargo CA Jr

更新日期：2017-06-01 00:00:00

abstract：Importance:Accurate, real-time case identification is needed to target interventions to improve quality and outcomes for hospitalized patients with heart failure. Problem lists may be useful for case identification but are often inaccurate or incomplete. Machine-learning approaches may improve accuracy of identificatio...

journal_title：JAMA cardiology

authors： Blecker S,Katz SD,Horwitz LI,Kuperman G,Park H,Gold A,Sontag D

更新日期：2016-12-01 00:00:00

abstract：IMPORTANCE:Dyslipidemia in young adults in the United States during their childbearing years is common, and the consequences for the next generation are poorly understood. Further understanding of the harmful consequences of elevated low-density lipoprotein cholesterol (LDL-C) levels in young adults may help to inform ...

journal_title：JAMA cardiology

authors： Mendelson MM,Lyass A,O'Donnell CJ,D'Agostino RB Sr,Levy D

更新日期：2016-04-01 00:00:00

abstract：Importance:The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated the benefit of lowering systolic blood pressure (SBP) to 120 mm Hg, yet other trials, such as Heart Outcomes Prevention Evaluation-3 (HOPE-3), did not find consistent benefit. How to incorporate these results into the treatment of those wit...

journal_title：JAMA cardiology

authors： Navar AM,Pencina MJ,Peterson ED

更新日期：2016-11-01 00:00:00

abstract：Importance:Early menarche and early menopause are associated with increased risk of cardiovascular disease (CVD) in midlife, but little is known about the association between reproductive life span and the risk of CVD. Objective:To investigate the association between the length of reproductive life span and risk of in...

journal_title：JAMA cardiology

authors： Mishra SR,Chung HF,Waller M,Dobson AJ,Greenwood DC,Cade JE,Giles GG,Bruinsma F,Simonsen MK,Hardy R,Kuh D,Gold EB,Crawford SL,Derby CA,Matthews KA,Demakakos P,Lee JS,Mizunuma H,Hayashi K,Sievert LL,Brown DE,Sandi

更新日期：2020-09-16 00:00:00

abstract：Importance:One-third of Medicare beneficiaries are enrolled in Medicare Advantage (MA), Medicare's private plan option. Medicare Advantage incentivizes performance on evidence-based care, but limited information exists using reliable clinical data to determine whether this translates into better quality for patients wi...

journal_title：JAMA cardiology

authors： Figueroa JF,Blumenthal DM,Feyman Y,Frakt AB,Turchin A,Doros G,Gao Q,Song Y,Joynt Maddox KE

更新日期：2019-03-01 00:00:00

abstract：Importance:Women are at higher risk of drug-induced torsade de pointes (TdP) than men. Androgens are protective. Influence of oral contraception on drug-induced TdP and QT prolongation is controversial. Objective:To determine if the extent of sotalol-induced corrected QT (QTc) prolongation and specific T-wave morpholo...

journal_title：JAMA cardiology

authors： Salem JE,Dureau P,Bachelot A,Germain M,Voiriot P,Lebourgeois B,Trégouët DA,Hulot JS,Funck-Brentano C

更新日期：2018-09-01 00:00:00

abstract：Importance:If we assume that women and men exhibit variations of the same fundamental vascular physiology, then conventional analyses of subclinical measures would suggest that women catch up to men by midlife in the extent of potentially important vascular disease. Alternatively, under the assumption that vascular phy...

journal_title：JAMA cardiology

authors： Ji H,Kim A,Ebinger JE,Niiranen TJ,Claggett BL,Bairey Merz CN,Cheng S

更新日期：2020-03-01 00:00:00

abstract：Importance:Sustained reductions in low-density lipoprotein cholesterol (LDL-C) with lipid-lowering therapies that require frequent dosing are reliant on patient adherence, and poor adherence is associated with worse clinical outcomes. Objective:To determine whether inclisiran, a small interfering RNA, reduces mean LDL...

journal_title：JAMA cardiology

authors： Ray KK,Stoekenbroek RM,Kallend D,Nishikido T,Leiter LA,Landmesser U,Wright RS,Wijngaard PLJ,Kastelein JJP

更新日期：2019-11-01 00:00:00

abstract：Importance:Acute mental stress can result in transient endothelial dysfunction, but the prognostic relevance of this phenomenon is unknown. Objective:To determine the association between mental stress-induced impairment in endothelium-dependent relaxation as assessed by brachial artery flow-mediated vasodilation and a...

journal_title：JAMA cardiology

authors： Lima BB,Hammadah M,Kim JH,Uphoff I,Shah A,Levantsevych O,Almuwaqqat Z,Moazzami K,Sullivan S,Ward L,Kutner M,Ko YA,Sheps DS,Bremner JD,Quyyumi AA,Vaccarino V

更新日期：2019-10-01 00:00:00

abstract：Importance:As many as 10% of women experience natural menopause by the age of 45 years. If confirmed, an increased risk of cardiovascular disease (CVD) and all-cause mortality associated with premature and early-onset menopause could be an important factor affecting risk of disease and mortality among middle-aged and o...

journal_title：JAMA cardiology

authors： Muka T,Oliver-Williams C,Kunutsor S,Laven JS,Fauser BC,Chowdhury R,Kavousi M,Franco OH

更新日期：2016-10-01 00:00:00

abstract：Importance:Low-density lipoprotein cholesterol (LDL-C)-lowering therapies are a cornerstone of prevention in atherosclerotic cardiovascular disease. With the introduction of generic formulations and the release of new therapies, including proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, contemporary Me...

journal_title：JAMA cardiology

authors： Sumarsono A,Lalani HS,Vaduganathan M,Navar AM,Fonarow GC,Das SR,Pandey A

更新日期：2021-01-01 00:00:00

abstract：Importance:Many of the quality measures used to assess accountable care organization (ACO) performance in the Medicare Shared Savings Program (MSSP) focus on disease control and medication use among patients with cardiovascular disease and diabetes. To date, the association between participation in the MSSP by provider...

journal_title：JAMA cardiology

authors： McWilliams JM,Najafzadeh M,Shrank WH,Polinski JM

更新日期：2017-09-01 00:00:00

abstract：Importance:Levels of proprotein convertase subtilisin kexin type 9 (PCSK9) vary markedly across the population and are influenced by genetic and nongenetic factors. Evolocumab is a fully human, monoclonal antibody against PCSK9 that reduces low-density lipoprotein cholesterol (LDL-C) levels by 55% to 75%. Whether the e...

journal_title：JAMA cardiology

authors： Desai NR,Giugliano RP,Wasserman SM,Gibbs JP,Liu T,Scott R,Sabatine MS

更新日期：2017-05-01 00:00:00

abstract：Importance:Bioresorbable scaffolds were designed to provide clinical benefits after their complete bioresorption. Prior studies demonstrated early risks with the Absorb polymeric bioresorbable vascular scaffold (BVS). Whether this risk profile changes over time during the course of its bioresorption is unknown. Object...

journal_title：JAMA cardiology

authors： Stone GW,Kimura T,Gao R,Kereiakes DJ,Ellis SG,Onuma Y,Chevalier B,Simonton C,Dressler O,Crowley A,Ali ZA,Serruys PW

更新日期：2019-12-01 00:00:00

abstract：IMPORTANCE:The adverse outcomes associated with atrial fibrillation (AF) have been studied in predominantly white cohorts. Racial differences in outcomes associated with AF merit continued investigation. OBJECTIVE:To evaluate the race-specific associations of AF with stroke, heart failure, coronary heart disease (CHD)...

journal_title：JAMA cardiology

authors： Magnani JW,Norby FL,Agarwal SK,Soliman EZ,Chen LY,Loehr LR,Alonso A

更新日期：2016-07-01 00:00:00

abstract：Importance:Cardiac dysfunction is a leading cause of morbidity and mortality in Duchenne muscular dystrophy (DMD). This case highlights the importance of steroids in treating cardiac complications of DMD and the dangers of discontinuing or switching between steroid classes. Objective:To recognize the presentation of a...

journal_title：JAMA cardiology

authors： Abutaleb ARA,McNally EM,Khan SS,Anderson AS,Carr JC,Wilcox JE

更新日期：2018-10-01 00:00:00

abstract：Importance:The Open-Label Study of Long-term Evaluation Against LDL-C (OSLER-1) evaluated the durability of long-term efficacy and safety during long-term therapy with evolocumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9). Objective:To determine whether LDL-C level reductions ...

journal_title：JAMA cardiology

authors： Koren MJ,Sabatine MS,Giugliano RP,Langslet G,Wiviott SD,Kassahun H,Ruzza A,Ma Y,Somaratne R,Raal FJ

更新日期：2017-06-01 00:00:00

abstract：Importance:Data sharing is as an expanding initiative for enhancing trust in the clinical research enterprise. Objective:To evaluate the feasibility, process, and outcomes of a reproduction analysis of the THERMOCOOL SMARTTOUCH Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation (SMART-AF) trial u...

journal_title：JAMA cardiology

authors： Gay HC,Baldridge AS,Huffman MD

更新日期：2017-12-01 00:00:00

abstract：Importance:Improvements in symptoms, functional capacity, and quality of life are among the key goals of edge-to-edge transcatheter mitral valve repair (TMVR) for mitral regurgitation. Objective:To examine health status outcomes among patients undergoing TMVR in clinical practice and the factors associated with improv...

journal_title：JAMA cardiology

authors： Arnold SV,Li Z,Vemulapalli S,Baron SJ,Mack MJ,Kosinski AS,Reynolds MR,Hermiller JB,Rumsfeld JS,Cohen DJ

更新日期：2018-12-01 00:00:00

abstract：Importance:Despite considerable improvements in heart failure care, mortality rates among patients in high-income countries have changed little since the early 2000s. Understanding the reasons underlying these trends may provide valuable clues for developing more targeted therapies and public health strategies. Object...

journal_title：JAMA cardiology

authors： Conrad N,Judge A,Canoy D,Tran J,Pinho-Gomes AC,Millett ERC,Salimi-Khorshidi G,Cleland JG,McMurray JJV,Rahimi K

更新日期：2019-11-01 00:00:00

abstract：Importance:Long-term blood pressure (BP) variability has emerged as a reproducible measure that is associated with heart failure independent of systemic BP. Visit-to-visit BP variability may be associated with the risk of heart failure early in the life course and thus may be reflected in subclinical alterations in car...

journal_title：JAMA cardiology

authors： Nwabuo CC,Yano Y,Moreira HT,Appiah D,Vasconcellos HD,Aghaji QN,Viera A,Rana JS,Shah RV,Murthy VL,Allen NB,Schreiner PJ,Lloyd-Jones DM,Lima JAC

更新日期：2020-07-01 00:00:00

abstract：Importance:Quality of percutaneous coronary intervention (PCI) is commonly assessed by risk-adjusted mortality. However, this metric may result in procedural risk aversion, especially for high-risk patients. Objective:To determine correlation and reclassification between hospital-level disease-specific mortality and P...

journal_title：JAMA cardiology

authors： Nathan AS,Xiang Q,Wojdyla D,Khatana SAM,Dayoub EJ,Wadhera RK,Bhatt DL,Kolansky DM,Kirtane AJ,Rao SV,Yeh RW,Groeneveld PW,Wang TY,Giri J

更新日期：2020-07-01 00:00:00

abstract：Importance:The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. Objective:To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Gl...

journal_title：JAMA cardiology

authors： Lam CSP,Giczewska A,Sliwa K,Edelmann F,Refsgaard J,Bocchi E,Ezekowitz JA,Hernandez AF,O'Connor CM,Roessig L,Patel MJ,Pieske B,Anstrom KJ,Armstrong PW,VICTORIA Study Group.

更新日期：2020-11-13 00:00:00

abstract：Importance:Increasing cardiology workforce diversity will expand the talent of the applicant pool and may reduce health care disparities. Objective:To assess US cardiology physician workforce demographics by sex and race/ethnicity in the context of the US population and the available pipelines of trainees. Design, Se...

journal_title：JAMA cardiology

authors： Mehta LS,Fisher K,Rzeszut AK,Lipner R,Mitchell S,Dill M,Acosta D,Oetgen WJ,Douglas PS

更新日期：2019-10-01 00:00:00

abstract：Importance:Limited evidence is available regarding the benefit and hazard of higher-intensity treatment to lower lipid levels among patients 75 years or older. As a result, guideline recommendations differ for this age group compared with younger patients. Objective:To determine the effect on outcomes and risks of com...

journal_title：JAMA cardiology

authors： Bach RG,Cannon CP,Giugliano RP,White JA,Lokhnygina Y,Bohula EA,Califf RM,Braunwald E,Blazing MA

更新日期：2019-09-01 00:00:00

abstract：Importance:Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery. Individuals with interleukin 6 receptor (IL6R) single-nucleotide polymorphisms (SNPs) who are not receiving IL6R blocking therapy have biomarker profiles...

journal_title：JAMA cardiology

authors： Cai T,Zhang Y,Ho YL,Link N,Sun J,Huang J,Cai TA,Damrauer S,Ahuja Y,Honerlaw J,Huang J,Costa L,Schubert P,Hong C,Gagnon D,Sun YV,Gaziano JM,Wilson P,Cho K,Tsao P,O'Donnell CJ,Liao KP,VA Million Veteran Program.

更新日期：2018-09-01 00:00:00

abstract：Importance:Myocardial replacement fibrosis has been reported to occur in one-third of patients with mitral valve prolapse (MVP) and significant mitral regurgitation (MR). However, it remains unknown whether there are detectable changes in myocardial metabolism suggestive of inflammation or ischemia that accompany the d...

journal_title：JAMA cardiology

authors： Miller MA,Adams DH,Pandis D,Robson PM,Pawale A,Pyzik R,Liao SL,El-Eshmawi A,Boateng P,Garg J,Waterford S,Weiner MM,Dukkipati SR,Reddy VY,Fayad ZA,Trivieri MG

更新日期：2020-09-01 00:00:00