Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

abstract：Importance:Transthyretin cardiac amyloidosis (also known as ATTR cardiac amyloidosis) is an increasingly recognized cause of heart failure with preserved ejection fraction. In single-center studies, technetium 99m pyrophosphate (Tc 99m PYP) cardiac imaging noninvasively detects ATTR cardiac amyloidosis, but the accurac...

journal_title：JAMA cardiology

authors： Castano A,Haq M,Narotsky DL,Goldsmith J,Weinberg RL,Morgenstern R,Pozniakoff T,Ruberg FL,Miller EJ,Berk JL,Dispenzieri A,Grogan M,Johnson G,Bokhari S,Maurer MS

更新日期：2016-11-01 00:00:00

abstract：Importance:Recent data support percutaneous revascularization as an alternative to coronary artery bypass grafting in unprotected left main (ULM) coronary lesions. However, the relevance of these trials to current practice is unclear, as patterns and outcomes of ULM percutaneous coronary intervention (PCI) in contempor...

journal_title：JAMA cardiology

authors： Valle JA,Tamez H,Abbott JD,Moussa ID,Messenger JC,Waldo SW,Kennedy KF,Masoudi FA,Yeh RW

更新日期：2019-02-01 00:00:00

abstract：Importance:Bioresorbable scaffolds were designed to provide clinical benefits after their complete bioresorption. Prior studies demonstrated early risks with the Absorb polymeric bioresorbable vascular scaffold (BVS). Whether this risk profile changes over time during the course of its bioresorption is unknown. Object...

journal_title：JAMA cardiology

authors： Stone GW,Kimura T,Gao R,Kereiakes DJ,Ellis SG,Onuma Y,Chevalier B,Simonton C,Dressler O,Crowley A,Ali ZA,Serruys PW

更新日期：2019-12-01 00:00:00

abstract：Importance:Computed tomography-derived fractional flow reserve (FFR-CT) is a novel, noninvasive test for myocardial ischemia. Clinicians using FFR-CT must be able to interpret individual FFR-CT results to determine subsequent patient care. Objective:To provide clinicians a means of interpreting individual FFR-CT resul...

journal_title：JAMA cardiology

authors： Cook CM,Petraco R,Shun-Shin MJ,Ahmad Y,Nijjer S,Al-Lamee R,Kikuta Y,Shiono Y,Mayet J,Francis DP,Sen S,Davies JE

更新日期：2017-07-01 00:00:00

abstract：Importance:Hospitalizations for worsening heart failure (WHF) represent an enormous public health and financial burden, with physicians, health systems, and payers placing increasing emphasis on hospitalization prevention. In addition, maximizing time out of the hospital is an important patient-centered outcome. In thi...

journal_title：JAMA cardiology

authors： Greene SJ,Mentz RJ,Felker GM

更新日期：2018-03-01 00:00:00

abstract：Importance:The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. Objective:To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Gl...

journal_title：JAMA cardiology

authors： Lam CSP,Giczewska A,Sliwa K,Edelmann F,Refsgaard J,Bocchi E,Ezekowitz JA,Hernandez AF,O'Connor CM,Roessig L,Patel MJ,Pieske B,Anstrom KJ,Armstrong PW,VICTORIA Study Group.

更新日期：2020-11-13 00:00:00

abstract：Importance:Long-term blood pressure (BP) variability has emerged as a reproducible measure that is associated with heart failure independent of systemic BP. Visit-to-visit BP variability may be associated with the risk of heart failure early in the life course and thus may be reflected in subclinical alterations in car...

journal_title：JAMA cardiology

authors： Nwabuo CC,Yano Y,Moreira HT,Appiah D,Vasconcellos HD,Aghaji QN,Viera A,Rana JS,Shah RV,Murthy VL,Allen NB,Schreiner PJ,Lloyd-Jones DM,Lima JAC

更新日期：2020-07-01 00:00:00

abstract：Importance:Racial differences are recognized in multiple cardiovascular parameters, including left ventricular hypertrophy and heart failure, which are 2 major manifestations of hypertrophic cardiomyopathy. The association of race with disease expression and outcomes among patients with hypertrophic cardiomyopathy is n...

journal_title：JAMA cardiology

authors： Eberly LA,Day SM,Ashley EA,Jacoby DL,Jefferies JL,Colan SD,Rossano JW,Semsarian C,Pereira AC,Olivotto I,Ingles J,Seidman CE,Channaoui N,Cirino AL,Han L,Ho CY,Lakdawala NK

更新日期：2020-01-01 00:00:00

abstract：Importance:Cardiac dysfunction is a leading cause of morbidity and mortality in Duchenne muscular dystrophy (DMD). This case highlights the importance of steroids in treating cardiac complications of DMD and the dangers of discontinuing or switching between steroid classes. Objective:To recognize the presentation of a...

journal_title：JAMA cardiology

authors： Abutaleb ARA,McNally EM,Khan SS,Anderson AS,Carr JC,Wilcox JE

更新日期：2018-10-01 00:00:00

abstract：Importance:Early menarche and early menopause are associated with increased risk of cardiovascular disease (CVD) in midlife, but little is known about the association between reproductive life span and the risk of CVD. Objective:To investigate the association between the length of reproductive life span and risk of in...

journal_title：JAMA cardiology

authors： Mishra SR,Chung HF,Waller M,Dobson AJ,Greenwood DC,Cade JE,Giles GG,Bruinsma F,Simonsen MK,Hardy R,Kuh D,Gold EB,Crawford SL,Derby CA,Matthews KA,Demakakos P,Lee JS,Mizunuma H,Hayashi K,Sievert LL,Brown DE,Sandi

更新日期：2020-09-16 00:00:00

abstract：Importance:Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery. Individuals with interleukin 6 receptor (IL6R) single-nucleotide polymorphisms (SNPs) who are not receiving IL6R blocking therapy have biomarker profiles...

journal_title：JAMA cardiology

authors： Cai T,Zhang Y,Ho YL,Link N,Sun J,Huang J,Cai TA,Damrauer S,Ahuja Y,Honerlaw J,Huang J,Costa L,Schubert P,Hong C,Gagnon D,Sun YV,Gaziano JM,Wilson P,Cho K,Tsao P,O'Donnell CJ,Liao KP,VA Million Veteran Program.

更新日期：2018-09-01 00:00:00

abstract：Importance:Improvements in symptoms, functional capacity, and quality of life are among the key goals of edge-to-edge transcatheter mitral valve repair (TMVR) for mitral regurgitation. Objective:To examine health status outcomes among patients undergoing TMVR in clinical practice and the factors associated with improv...

journal_title：JAMA cardiology

authors： Arnold SV,Li Z,Vemulapalli S,Baron SJ,Mack MJ,Kosinski AS,Reynolds MR,Hermiller JB,Rumsfeld JS,Cohen DJ

更新日期：2018-12-01 00:00:00

abstract：Importance:Quality of percutaneous coronary intervention (PCI) is commonly assessed by risk-adjusted mortality. However, this metric may result in procedural risk aversion, especially for high-risk patients. Objective:To determine correlation and reclassification between hospital-level disease-specific mortality and P...

journal_title：JAMA cardiology

authors： Nathan AS,Xiang Q,Wojdyla D,Khatana SAM,Dayoub EJ,Wadhera RK,Bhatt DL,Kolansky DM,Kirtane AJ,Rao SV,Yeh RW,Groeneveld PW,Wang TY,Giri J

更新日期：2020-07-01 00:00:00

abstract：IMPORTANCE:Dyslipidemia in young adults in the United States during their childbearing years is common, and the consequences for the next generation are poorly understood. Further understanding of the harmful consequences of elevated low-density lipoprotein cholesterol (LDL-C) levels in young adults may help to inform ...

journal_title：JAMA cardiology

authors： Mendelson MM,Lyass A,O'Donnell CJ,D'Agostino RB Sr,Levy D

更新日期：2016-04-01 00:00:00

abstract：Importance:Levels of proprotein convertase subtilisin kexin type 9 (PCSK9) vary markedly across the population and are influenced by genetic and nongenetic factors. Evolocumab is a fully human, monoclonal antibody against PCSK9 that reduces low-density lipoprotein cholesterol (LDL-C) levels by 55% to 75%. Whether the e...

journal_title：JAMA cardiology

authors： Desai NR,Giugliano RP,Wasserman SM,Gibbs JP,Liu T,Scott R,Sabatine MS

更新日期：2017-05-01 00:00:00

abstract：Importance:Determining blood pressure (BP) patterns in young adulthood that are associated with cardiovascular disease (CVD) events in later life may help to identify young adults who have an increased risk for CVD. Objective:To determine whether the long-term variability of BP across clinical visits and the rate of c...

journal_title：JAMA cardiology

authors： Yano Y,Reis JP,Lewis CE,Sidney S,Pletcher MJ,Bibbins-Domingo K,Navar AM,Peterson ED,Bancks MP,Kanegae H,Gidding SS,Muntner P,Lloyd-Jones DM

更新日期：2020-04-01 00:00:00

abstract：Importance:Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducing the risk of the development or progression of heart failure. In a landmark trial called Empagliflozin, Cardiovascular Outcomes, and M...

journal_title：JAMA cardiology

authors： Packer M,Anker SD,Butler J,Filippatos G,Zannad F

更新日期：2017-09-01 00:00:00

abstract：Importance:The Open-Label Study of Long-term Evaluation Against LDL-C (OSLER-1) evaluated the durability of long-term efficacy and safety during long-term therapy with evolocumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9). Objective:To determine whether LDL-C level reductions ...

journal_title：JAMA cardiology

authors： Koren MJ,Sabatine MS,Giugliano RP,Langslet G,Wiviott SD,Kassahun H,Ruzza A,Ma Y,Somaratne R,Raal FJ

更新日期：2017-06-01 00:00:00

abstract：Importance:Somatic mutations causing clonal expansion of hematopoietic cells (clonal hematopoiesis of indeterminate potential [CHIP]) are increased with age and associated with atherosclerosis and inflammation. Age and inflammation are the major risk factors for heart failure, yet the association of CHIP with heart fai...

journal_title：JAMA cardiology

authors： Dorsheimer L,Assmus B,Rasper T,Ortmann CA,Ecke A,Abou-El-Ardat K,Schmid T,Brüne B,Wagner S,Serve H,Hoffmann J,Seeger F,Dimmeler S,Zeiher AM,Rieger MA

更新日期：2019-01-01 00:00:00

abstract：Importance:Echocardiographic left ventricular global longitudinal strain (GLS) detects early subclinical ventricular dysfunction and can be used in patients receiving potentially cardiotoxic chemotherapy. A meta-analysis of the prognostic value of GLS for cancer therapy-related cardiac dysfunction (CTRCD) has not been ...

journal_title：JAMA cardiology

authors： Oikonomou EK,Kokkinidis DG,Kampaktsis PN,Amir EA,Marwick TH,Gupta D,Thavendiranathan P

更新日期：2019-10-01 00:00:00

abstract：Importance:Cardiac stress testing is often performed prior to noncardiac surgery, although trends in use of preoperative stress testing and the effect of testing on cardiovascular outcomes are currently unknown. Objective:To describe temporal trends and outcomes of preoperative cardiac stress testing from 2004 to 2017...

journal_title：JAMA cardiology

authors： Rubin DS,Hughey R,Gerlach RM,Ham SA,Ward RP,Nagele P

更新日期：2021-01-01 00:00:00

abstract：Importance:High-resolution stratification of risk of sudden cardiac arrest (SCA) in individual patients is a tool that is necessary for achieving effective and efficient application of data generated by population-based research. This concept is at the core of initiatives for merging cost effectiveness with maximized c...

journal_title：JAMA cardiology

authors： Myerburg RJ,Goldberger JJ

更新日期：2017-06-01 00:00:00

abstract：Importance:Volumetric measurements by transthoracic echocardiogram may better reflect left ventricular (LV) remodeling than conventional linear LV dimensions. However, the association of LV volumes with mortality in patients with chronic hemodynamically significant aortic regurgitation (AR) is unknown. Objective:To as...

journal_title：JAMA cardiology

authors： Yang LT,Anand V,Zambito EI,Pellikka PA,Scott CG,Thapa P,Padang R,Takeuchi M,Nishimura RA,Enriquez-Sarano M,Michelena HI

更新日期：2020-11-04 00:00:00

abstract：IMPORTANCE:Reduced rates of cardiac catheterization, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) are an unintended consequence of public reporting of cardiogenic shock outcomes in New York. OBJECTIVES:To evaluate whether the referral rates for cardiac catheterization, PCI, or CABG...

journal_title：JAMA cardiology

authors： Bangalore S,Guo Y,Xu J,Blecker S,Gupta N,Feit F,Hochman JS

更新日期：2016-09-01 00:00:00

abstract：Importance:If we assume that women and men exhibit variations of the same fundamental vascular physiology, then conventional analyses of subclinical measures would suggest that women catch up to men by midlife in the extent of potentially important vascular disease. Alternatively, under the assumption that vascular phy...

journal_title：JAMA cardiology

authors： Ji H,Kim A,Ebinger JE,Niiranen TJ,Claggett BL,Bairey Merz CN,Cheng S

更新日期：2020-03-01 00:00:00

abstract：Importance:It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective:To describe baseline characteristics of participants en...

journal_title：JAMA cardiology

authors： Hochman JS,Reynolds HR,Bangalore S,O'Brien SM,Alexander KP,Senior R,Boden WE,Stone GW,Goodman SG,Lopes RD,Lopez-Sendon J,White HD,Maggioni AP,Shaw LJ,Min JK,Picard MH,Berman DS,Chaitman BR,Mark DB,Spertus JA,Cyr D

更新日期：2019-03-01 00:00:00

abstract：Importance:With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection is associated with HF with reduc...

journal_title：JAMA cardiology

authors： Freiberg MS,Chang CH,Skanderson M,Patterson OV,DuVall SL,Brandt CA,So-Armah KA,Vasan RS,Oursler KA,Gottdiener J,Gottlieb S,Leaf D,Rodriguez-Barradas M,Tracy RP,Gibert CL,Rimland D,Bedimo RJ,Brown ST,Goetz MB,Warner

更新日期：2017-05-01 00:00:00

abstract：Importance:Physicians have been criticized for having an overly enthusiastic response to new device approvals, especially for novel technologies. However, to our knowledge, the rates of new product adoption and patterns of new device usage in clinical practice have not been well described. Objective:To characterize th...

journal_title：JAMA cardiology

authors： Chau KH,Kennedy KF,Messenger JC,Garratt KN,Maddox TM,Yeh RW,Kirtane AJ

更新日期：2019-06-01 00:00:00

abstract：Importance:Cardiac resynchronization therapy (CRT) provides significant reduction in morbidity and mortality in select patients with left ventricular systolic dysfunction and specific parameters of electrocardiographic evidence of dyssynchrony. Relative to the 2012 American College of Cardiology/American Heart Associat...

journal_title：JAMA cardiology

authors： Sandhu A,Bao H,Minges KE,Varosy PD,Borne RT,Zipse MM,Marzec L,Peterson P,Masoudi F,Bradley SM

更新日期：2019-08-01 00:00:00

abstract：Importance:In clinical trials, transcatheter aortic valve replacement (TAVR) has been shown to improve symptoms and quality of life. As this technology moves into general clinical practice, evaluation of the health status outcomes among unselected patients treated with TAVR is of critical importance. Objective:To exam...

journal_title：JAMA cardiology

authors： Arnold SV,Spertus JA,Vemulapalli S,Li Z,Matsouaka RA,Baron SJ,Vora AN,Mack MJ,Reynolds MR,Rumsfeld JS,Cohen DJ

更新日期：2017-04-01 00:00:00