Association of Baseline Low-Density Lipoprotein Cholesterol and Percentage Low-Density Lipoprotein Cholesterol Reduction With Statins, Ezetimibe, and PCSK9 Inhibition.

Abstract:

Importance:Low-density lipoprotein cholesterol (LDL-C) is an important modifiable risk factor for atherosclerotic cardiovascular disease. It is unclear whether the percentage LDL-C lowering with pharmacotherapies differs on the basis of baseline LDL-C levels. Objective:To evaluate the association between baseline LDL-C levels and the percentage LDL-C reduction with a statin, ezetimibe, and a PCSK9 inhibitor. Design, Setting, and Participants:This secondary exploratory study analyzed data from 3 randomized placebo-controlled clinical trials (Aggrastat to Zocor-Thrombolysis in Myocardial Infarction 21 [A to Z-TIMI 21], Improved Reduction of Outcomes: Vytorin Efficacy International Trial [IMPROVE-IT], and Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk [FOURIER]) of lipid-lowering therapies (statin, ezetimibe, and a PCSK9 inhibitor) and included participants with atherosclerotic cardiovascular disease. Analyses took place form April to October 2020. Interventions:In A to Z-TIMI 21, 1:1 randomization to simvastatin, 40 mg, daily for 30 days followed by 80 mg daily thereafter vs placebo for 4 months followed by simvastatin, 20 mg, daily thereafter. In IMPROVE-IT, 1:1 randomization to ezetimibe, 10 mg, daily plus simvastatin, 40 mg, daily vs placebo plus simvastatin, 40 mg, daily. In FOURIER, 1:1 randomization to evolocumab, 140 mg, every 2 weeks or 420 mg monthly vs matching placebo. Main Outcomes and Measures:The percentage LDL-C reduction at either 1 month (A to Z-TIMI 21, IMPROVE-IT) or 3 months (FOURIER) as a function of baseline LDL-C level. Data were modeled using a generalized linear regression model. Results:A total of 3187 patients from A to Z-TIMI 21, 10 680 patients from IMPROVE-IT, and 25 847 patients from FOURIER were analyzed. There was a higher percentage reduction in LDL-C levels with evolocumab in patients with lower baseline LDL-C levels, ranging from 59.4% (95% CI, 59.1%-59.8%) in patients with a baseline LDL-C level of 130 mg/dL to 66.1% (95% CI, 65.6%-66.6%) in patients with a baseline LDL-C level of 70 mg/dL (P < .001). In contrast, across the same range of baseline LDL-C level, there was a more modest difference for simvastatin (44.6% [95% CI, 43.9%-45.2%] vs 47.8% [95% CI, 46.4%-49.2%]; P < .001) and minimal difference with ezetimibe (25.0% [95% CI, 23.3%-26.6%] vs 26.2% [95% CI, 24.2%-28.1%]; P = .007). Conclusions and Relevance:The percentage LDL-C reduction with statins, ezetimibe, and PCSK9 inhibition is not attenuated in patients starting with lower baseline LDL-C levels and is 6.6% greater for PCSK9 inhibition. These data are encouraging for the use of intensive LDL-C-lowering therapy even for patients with lower LDL-C levels.

journal_name

JAMA Cardiol

journal_title

JAMA cardiology

authors

Marcusa DP,Giugliano RP,Park JG,de Lemos JA,Cannon CP,Sabatine MS

doi

10.1001/jamacardio.2020.6184

subject

Has Abstract

pub_date

2020-11-13 00:00:00

eissn

2380-6583

issn

2380-6591

pii

2773088

pub_type

杂志文章
  • Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

    abstract:Importance:Transcatheter aortic valve replacement (TAVR) is an established alternative to surgery for patients with severe symptomatic aortic stenosis. Adjunctive antithrombotic therapy used to mitigate thrombotic risks in patients undergoing TAVR must be balanced against bleeding complications, since both are associat...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,评审

    doi:10.1001/jamacardio.2019.4367

    authors: Saito Y,Nazif T,Baumbach A,Tchétché D,Latib A,Kaple R,Forrest J,Prendergast B,Lansky A

    更新日期:2020-01-01 00:00:00

  • Feasibility, Process, and Outcomes of Cardiovascular Clinical Trial Data Sharing: A Reproduction Analysis of the SMART-AF Trial.

    abstract:Importance:Data sharing is as an expanding initiative for enhancing trust in the clinical research enterprise. Objective:To evaluate the feasibility, process, and outcomes of a reproduction analysis of the THERMOCOOL SMARTTOUCH Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation (SMART-AF) trial u...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.3808

    authors: Gay HC,Baldridge AS,Huffman MD

    更新日期:2017-12-01 00:00:00

  • Association of Changes in Medication Use and Adherence With Accountable Care Organization Exposure in Patients With Cardiovascular Disease or Diabetes.

    abstract:Importance:Many of the quality measures used to assess accountable care organization (ACO) performance in the Medicare Shared Savings Program (MSSP) focus on disease control and medication use among patients with cardiovascular disease and diabetes. To date, the association between participation in the MSSP by provider...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.2172

    authors: McWilliams JM,Najafzadeh M,Shrank WH,Polinski JM

    更新日期:2017-09-01 00:00:00

  • Outpatient Worsening Heart Failure as a Target for Therapy: A Review.

    abstract:Importance:Hospitalizations for worsening heart failure (WHF) represent an enormous public health and financial burden, with physicians, health systems, and payers placing increasing emphasis on hospitalization prevention. In addition, maximizing time out of the hospital is an important patient-centered outcome. In thi...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.5250

    authors: Greene SJ,Mentz RJ,Felker GM

    更新日期:2018-03-01 00:00:00

  • Sudden Cardiac Arrest Risk Assessment: Population Science and the Individual Risk Mandate.

    abstract:Importance:High-resolution stratification of risk of sudden cardiac arrest (SCA) in individual patients is a tool that is necessary for achieving effective and efficient application of data generated by population-based research. This concept is at the core of initiatives for merging cost effectiveness with maximized c...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,评审

    doi:10.1001/jamacardio.2017.0266

    authors: Myerburg RJ,Goldberger JJ

    更新日期:2017-06-01 00:00:00

  • Racial Differences in Atrial Fibrillation-Related Cardiovascular Disease and Mortality: The Atherosclerosis Risk in Communities (ARIC) Study.

    abstract:IMPORTANCE:The adverse outcomes associated with atrial fibrillation (AF) have been studied in predominantly white cohorts. Racial differences in outcomes associated with AF merit continued investigation. OBJECTIVE:To evaluate the race-specific associations of AF with stroke, heart failure, coronary heart disease (CHD)...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.1025

    authors: Magnani JW,Norby FL,Agarwal SK,Soliman EZ,Chen LY,Loehr LR,Alonso A

    更新日期:2016-07-01 00:00:00

  • Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.

    abstract:Importance:The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH. Objective:To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time from index HFH in the Vericiguat Gl...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2020.6455

    authors: Lam CSP,Giczewska A,Sliwa K,Edelmann F,Refsgaard J,Bocchi E,Ezekowitz JA,Hernandez AF,O'Connor CM,Roessig L,Patel MJ,Pieske B,Anstrom KJ,Armstrong PW,VICTORIA Study Group.

    更新日期:2020-11-13 00:00:00

  • The Burden of Cardiovascular Diseases Among US States, 1990-2016.

    abstract:Importance:Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective:To quantify and describe levels and tren...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2018.0385

    authors: Global Burden of Cardiovascular Diseases Collaboration.,Roth GA,Johnson CO,Abate KH,Abd-Allah F,Ahmed M,Alam K,Alam T,Alvis-Guzman N,Ansari H,Ärnlöv J,Atey TM,Awasthi A,Awoke T,Barac A,Bärnighausen T,Bedi N,Bennett D,

    更新日期:2018-05-01 00:00:00

  • Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the PARTNER Trial.

    abstract:Importance:Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. Objective:To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Design, Set...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamacardio.2017.3306

    authors: Douglas PS,Leon MB,Mack MJ,Svensson LG,Webb JG,Hahn RT,Pibarot P,Weissman NJ,Miller DC,Kapadia S,Herrmann HC,Kodali SK,Makkar RR,Thourani VH,Lerakis S,Lowry AM,Rajeswaran J,Finn MT,Alu MC,Smith CR,Blackstone EH,

    更新日期:2017-11-01 00:00:00

  • Differences in Management of Coronary Artery Disease in Patients With Medicare Advantage vs Traditional Fee-for-Service Medicare Among Cardiology Practices.

    abstract:Importance:One-third of Medicare beneficiaries are enrolled in Medicare Advantage (MA), Medicare's private plan option. Medicare Advantage incentivizes performance on evidence-based care, but limited information exists using reliable clinical data to determine whether this translates into better quality for patients wi...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.0007

    authors: Figueroa JF,Blumenthal DM,Feyman Y,Frakt AB,Turchin A,Doros G,Gao Q,Song Y,Joynt Maddox KE

    更新日期:2019-03-01 00:00:00

  • Understanding the Role of P Values and Hypothesis Tests in Clinical Research.

    abstract::P values and hypothesis testing methods are frequently misused in clinical research. Much of this misuse appears to be owing to the widespread, mistaken belief that they provide simple, reliable, and objective triage tools for separating the true and important from the untrue or unimportant. The primary focus in inter...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.3312

    authors: Mark DB,Lee KL,Harrell FE Jr

    更新日期:2016-12-01 00:00:00

  • Resuscitation Practices Associated With Survival After In-Hospital Cardiac Arrest: A Nationwide Survey.

    abstract:IMPORTANCE:Although survival of patients with in-hospital cardiac arrest varies markedly among hospitals, specific resuscitation practices that distinguish sites with higher cardiac arrest survival rates remain unknown. OBJECTIVE:To identify resuscitation practices associated with higher rates of in-hospital cardiac a...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.0073

    authors: Chan PS,Krein SL,Tang F,Iwashyna TJ,Harrod M,Kennedy M,Lehrich J,Kronick S,Nallamothu BK,American Heart Association's Get With the Guidelines–Resuscitation Investigators.

    更新日期:2016-05-01 00:00:00

  • Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study.

    abstract:Importance:The Open-Label Study of Long-term Evaluation Against LDL-C (OSLER-1) evaluated the durability of long-term efficacy and safety during long-term therapy with evolocumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9). Objective:To determine whether LDL-C level reductions ...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.0747

    authors: Koren MJ,Sabatine MS,Giugliano RP,Langslet G,Wiviott SD,Kassahun H,Ruzza A,Ma Y,Somaratne R,Raal FJ

    更新日期:2017-06-01 00:00:00

  • Trends in Utilization and Cost of Low-Density Lipoprotein Cholesterol-Lowering Therapies Among Medicare Beneficiaries: An Analysis From the Medicare Part D Database.

    abstract:Importance:Low-density lipoprotein cholesterol (LDL-C)-lowering therapies are a cornerstone of prevention in atherosclerotic cardiovascular disease. With the introduction of generic formulations and the release of new therapies, including proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, contemporary Me...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2020.3723

    authors: Sumarsono A,Lalani HS,Vaduganathan M,Navar AM,Fonarow GC,Das SR,Pandey A

    更新日期:2021-01-01 00:00:00

  • Assessing and Refining Myocardial Infarction Risk Estimation Among Patients With Human Immunodeficiency Virus: A Study by the Centers for AIDS Research Network of Integrated Clinical Systems.

    abstract:Importance:Persons with human immunodeficiency virus (HIV) that is treated with antiretroviral therapy have improved longevity but face an elevated risk of myocardial infarction (MI) due to common MI risk factors and HIV-specific factors. Despite these elevated MI rates, optimal methods to predict MI risks for HIV-infe...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2016.4494

    authors: Feinstein MJ,Nance RM,Drozd DR,Ning H,Delaney JA,Heckbert SR,Budoff MJ,Mathews WC,Kitahata MM,Saag MS,Eron JJ,Moore RD,Achenbach CJ,Lloyd-Jones DM,Crane HM

    更新日期:2017-02-01 00:00:00

  • Association of Depression With Mortality in Older Adults Undergoing Transcatheter or Surgical Aortic Valve Replacement.

    abstract:Importance:Depression is increasingly recognized as a risk factor for adverse outcomes in cardiovascular disease. However, little is known about depression in older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement. Objective:To determine the prevalence of depression and its associatio...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamacardio.2017.5064

    authors: Drudi LM,Ades M,Turkdogan S,Huynh C,Lauck S,Webb JG,Piazza N,Martucci G,Langlois Y,Perrault LP,Asgar AW,Labinaz M,Lamy A,Noiseux N,Peterson MD,Arora RC,Lindman BR,Bendayan M,Mancini R,Trnkus A,Kim DH,Popma JJ,

    更新日期:2018-03-01 00:00:00

  • Effects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure: Proposal of a Novel Mechanism of Action.

    abstract:Importance:Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducing the risk of the development or progression of heart failure. In a landmark trial called Empagliflozin, Cardiovascular Outcomes, and M...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.2275

    authors: Packer M,Anker SD,Butler J,Filippatos G,Zannad F

    更新日期:2017-09-01 00:00:00

  • Assessing Cardiovascular Risk to Guide Hypertension Diagnosis and Treatment.

    abstract:Importance:The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated the benefit of lowering systolic blood pressure (SBP) to 120 mm Hg, yet other trials, such as Heart Outcomes Prevention Evaluation-3 (HOPE-3), did not find consistent benefit. How to incorporate these results into the treatment of those wit...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.2861

    authors: Navar AM,Pencina MJ,Peterson ED

    更新日期:2016-11-01 00:00:00

  • Myocarditis in Duchenne Muscular Dystrophy After Changing Steroids.

    abstract:Importance:Cardiac dysfunction is a leading cause of morbidity and mortality in Duchenne muscular dystrophy (DMD). This case highlights the importance of steroids in treating cardiac complications of DMD and the dangers of discontinuing or switching between steroid classes. Objective:To recognize the presentation of a...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2018.2695

    authors: Abutaleb ARA,McNally EM,Khan SS,Anderson AS,Carr JC,Wilcox JE

    更新日期:2018-10-01 00:00:00

  • Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial.

    abstract:Importance:Limited evidence is available regarding the benefit and hazard of higher-intensity treatment to lower lipid levels among patients 75 years or older. As a result, guideline recommendations differ for this age group compared with younger patients. Objective:To determine the effect on outcomes and risks of com...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamacardio.2019.2306

    authors: Bach RG,Cannon CP,Giugliano RP,White JA,Lokhnygina Y,Bohula EA,Califf RM,Braunwald E,Blazing MA

    更新日期:2019-09-01 00:00:00

  • Use of Cardiac Resynchronization Therapy Defibrillator in US Hospitals.

    abstract:Importance:Cardiac resynchronization therapy (CRT) provides significant reduction in morbidity and mortality in select patients with left ventricular systolic dysfunction and specific parameters of electrocardiographic evidence of dyssynchrony. Relative to the 2012 American College of Cardiology/American Heart Associat...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.1755

    authors: Sandhu A,Bao H,Minges KE,Varosy PD,Borne RT,Zipse MM,Marzec L,Peterson P,Masoudi F,Bradley SM

    更新日期:2019-08-01 00:00:00

  • Diagnostic Accuracy of Computed Tomography-Derived Fractional Flow Reserve : A Systematic Review.

    abstract:Importance:Computed tomography-derived fractional flow reserve (FFR-CT) is a novel, noninvasive test for myocardial ischemia. Clinicians using FFR-CT must be able to interpret individual FFR-CT results to determine subsequent patient care. Objective:To provide clinicians a means of interpreting individual FFR-CT resul...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.1314

    authors: Cook CM,Petraco R,Shun-Shin MJ,Ahmad Y,Nijjer S,Al-Lamee R,Kikuta Y,Shiono Y,Mayet J,Francis DP,Sen S,Davies JE

    更新日期:2017-07-01 00:00:00

  • Enhanced American College of Cardiology/American Heart Association Strategy for Prevention of Sudden Cardiac Death in High-Risk Patients With Hypertrophic Cardiomyopathy.

    abstract:Importance:Strategies for reliable selection of high-risk patients with hypertrophic cardiomyopathy (HCM) for prevention of sudden cardiac death (SCD) with implantable cardioverter/defibrillators (ICDs) are incompletely resolved. Objective:To assess the reliability of SCD prediction methods leading to prophylactic ICD...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.1391

    authors: Maron MS,Rowin EJ,Wessler BS,Mooney PJ,Fatima A,Patel P,Koethe BC,Romashko M,Link MS,Maron BJ

    更新日期:2019-07-01 00:00:00

  • Association Between Circulating Baseline Proprotein Convertase Subtilisin Kexin Type 9 Levels and Efficacy of Evolocumab.

    abstract:Importance:Levels of proprotein convertase subtilisin kexin type 9 (PCSK9) vary markedly across the population and are influenced by genetic and nongenetic factors. Evolocumab is a fully human, monoclonal antibody against PCSK9 that reduces low-density lipoprotein cholesterol (LDL-C) levels by 55% to 75%. Whether the e...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2016.5395

    authors: Desai NR,Giugliano RP,Wasserman SM,Gibbs JP,Liu T,Scott R,Sabatine MS

    更新日期:2017-05-01 00:00:00

  • Current Demographic Status of Cardiologists in the United States.

    abstract:Importance:Increasing cardiology workforce diversity will expand the talent of the applicant pool and may reduce health care disparities. Objective:To assess US cardiology physician workforce demographics by sex and race/ethnicity in the context of the US population and the available pipelines of trainees. Design, Se...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.3247

    authors: Mehta LS,Fisher K,Rzeszut AK,Lipner R,Mitchell S,Dill M,Acosta D,Oetgen WJ,Douglas PS

    更新日期:2019-10-01 00:00:00

  • Association of Public Health Initiatives With Outcomes for Out-of-Hospital Cardiac Arrest at Home and in Public Locations.

    abstract:Importance:Little is known about the influence of comprehensive public health initiatives according to out-of-hospital cardiac arrest (OHCA) location, particularly at home, where resuscitation efforts and outcomes have historically been poor. Objective:To describe temporal trends in bystander cardiopulmonary resuscita...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.3471

    authors: Fordyce CB,Hansen CM,Kragholm K,Dupre ME,Jollis JG,Roettig ML,Becker LB,Hansen SM,Hinohara TT,Corbett CC,Monk L,Nelson RD,Pearson DA,Tyson C,van Diepen S,Anderson ML,McNally B,Granger CB

    更新日期:2017-11-01 00:00:00

  • Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study.

    abstract:Importance:With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection is associated with HF with reduc...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2017.0264

    authors: Freiberg MS,Chang CH,Skanderson M,Patterson OV,DuVall SL,Brandt CA,So-Armah KA,Vasan RS,Oursler KA,Gottdiener J,Gottlieb S,Leaf D,Rodriguez-Barradas M,Tracy RP,Gibert CL,Rimland D,Bedimo RJ,Brown ST,Goetz MB,Warner

    更新日期:2017-05-01 00:00:00

  • Association of Transient Endothelial Dysfunction Induced by Mental Stress With Major Adverse Cardiovascular Events in Men and Women With Coronary Artery Disease.

    abstract:Importance:Acute mental stress can result in transient endothelial dysfunction, but the prognostic relevance of this phenomenon is unknown. Objective:To determine the association between mental stress-induced impairment in endothelium-dependent relaxation as assessed by brachial artery flow-mediated vasodilation and a...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2019.3252

    authors: Lima BB,Hammadah M,Kim JH,Uphoff I,Shah A,Levantsevych O,Almuwaqqat Z,Moazzami K,Sullivan S,Ward L,Kutner M,Ko YA,Sheps DS,Bremner JD,Quyyumi AA,Vaccarino V

    更新日期:2019-10-01 00:00:00

  • Association of Maternal Prepregnancy Dyslipidemia With Adult Offspring Dyslipidemia in Excess of Anthropometric, Lifestyle, and Genetic Factors in the Framingham Heart Study.

    abstract:IMPORTANCE:Dyslipidemia in young adults in the United States during their childbearing years is common, and the consequences for the next generation are poorly understood. Further understanding of the harmful consequences of elevated low-density lipoprotein cholesterol (LDL-C) levels in young adults may help to inform ...

    journal_title:JAMA cardiology

    pub_type: 杂志文章

    doi:10.1001/jamacardio.2015.0304

    authors: Mendelson MM,Lyass A,O'Donnell CJ,D'Agostino RB Sr,Levy D

    更新日期:2016-04-01 00:00:00

  • Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis.

    abstract:Importance:Observational studies have reported an association between low serum vitamin D levels and elevated risk of cardiovascular disease (CVD) events, but such studies cannot prove causation because of possible unmeasured confounding. Objective:We conducted a meta-analysis of randomized clinical trials that tested...

    journal_title:JAMA cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamacardio.2019.1870

    authors: Barbarawi M,Kheiri B,Zayed Y,Barbarawi O,Dhillon H,Swaid B,Yelangi A,Sundus S,Bachuwa G,Alkotob ML,Manson JE

    更新日期:2019-08-01 00:00:00