当前位置： SCI文献检索 > BIOORGANIC CHEMISTRY期刊下所有文献 > Graft copolymerization of acrylamide on chitosan-co-chitin and its application for immobilization of Aspergillus sp. RL2Ct cutinase.

Graft copolymerization of acrylamide on chitosan-co-chitin and its application for immobilization of Aspergillus sp. RL2Ct cutinase.

Abstract：

:The synthesis of chitosan (Chs) and chitin (Chi) copolymer and grafting of acrylamide (AAm) onto the synthesized copolymer have been carried out by chemical methods. The grafted copolymer was characterized by FTIR, SEM and XRD. The extracellular cutinase of Aspergillus sp. RL2Ct (E.C. 3.1.1.3) was purified to 4.46 fold with 16.1% yield using acetone precipitation and DEAE sepharose ion exchange chromatography. It was immobilized by adsorption on the grafted copolymer. The immobilized enzyme was found to be more stable then the free enzyme and has a good binding efficiency (78.8%) with the grafted copolymer. The kinetic parameters KM and Vmax for free and immobilized cutinase were found to be 0.55mM and 1410μmolmin-1mg-1 protein, 2.99mM and 996μmolmin-1mg-1 protein, respectively. The immobilized cutinase was recycled 64 times without considerable loss of activity. The matrix (Chs-co-Chi-g-poly(AAm)) prepared and cutinase immobilized on the matrix have potential applications in enzyme immobilization and organic synthesis respectively.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Kumari V,Kumar S,Kaur I,Bhalla TC

doi

10.1016/j.bioorg.2016.11.006

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

34-43

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(16)30236-X

journal_volume

70

pub_type

杂志文章

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