Quantitative Evaluation of Atlas-based Attenuation Correction for Brain PET in an Integrated Time-of-Flight PET/MR Imaging System.

Abstract:

:Purpose To assess the patient-dependent accuracy of atlas-based attenuation correction (ATAC) for brain positron emission tomography (PET) in an integrated time-of-flight (TOF) PET/magnetic resonance (MR) imaging system. Materials and Methods Thirty recruited patients provided informed consent in this institutional review board-approved study. All patients underwent whole-body fluorodeoxyglucose PET/computed tomography (CT) followed by TOF PET/MR imaging. With use of TOF PET data, PET images were reconstructed with four different attenuation correction (AC) methods: PET with patient CT-based AC (CTAC), PET with ATAC (air and bone from an atlas), PET with ATACpatientBone (air and tissue from the atlas with patient bone), and PET with ATACboneless (air and tissue from the atlas without bone). For quantitative evaluation, PET mean activity concentration values were measured in 14 1-mL volumes of interest (VOIs) distributed throughout the brain and statistical significance was tested with a paired t test. Results The mean overall difference (±standard deviation) of PET with ATAC compared with PET with CTAC was -0.69 kBq/mL ± 0.60 (-4.0% ± 3.2) (P < .001). The results were patient dependent (range, -9.3% to 0.57%) and VOI dependent (range, -5.9 to -2.2). In addition, when bone was not included for AC, the overall difference of PET with ATACboneless (-9.4% ± 3.7) was significantly worse than that of PET with ATAC (-4.0% ± 3.2) (P < .001). Finally, when patient bone was used for AC instead of atlas bone, the overall difference of PET with ATACpatientBone (-1.5% ± 1.5) improved over that of PET with ATAC (-4.0% ± 3.2) (P < .001). Conclusion ATAC in PET/MR imaging achieves similar quantification accuracy to that from CTAC by means of atlas-based bone compensation. However, patient-specific anatomic differences from the atlas causes bone attenuation differences and misclassified sinuses, which result in patient-dependent performance variation of ATAC. © RSNA, 2017 Online supplemental material is available for this article.

journal_name

Radiology

journal_title

Radiology

authors

Yang J,Jian Y,Jenkins N,Behr SC,Hope TA,Larson PEZ,Vigneron D,Seo Y

doi

10.1148/radiol.2017161603

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

169-179

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

284

pub_type

杂志文章
  • Scanning slit chest radiography: a practical and efficient scatter control design.

    abstract:PURPOSE:To design a chest radiography unit that eliminates scatter. MATERIALS AND METHODS:A scanning slit radiography unit that also incorporates a conventional grid was designed. The scanning slit geometry defined a 10-mm-wide beam at the image receptor. RESULTS:With a typical heavy-duty radiographic tube, the propo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.190.2.8284410

    authors: Barnes GT,Wu X,Sanders PC

    更新日期:1994-02-01 00:00:00

  • Detection of choledocholithiasis: comparison of unenhanced helical CT and endoscopic retrograde cholangiopancreatography.

    abstract:PURPOSE:To compare unenhanced helical computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) in the detection of common bile duct calculi. MATERIALS AND METHODS:Within 13 months, 51 patients (aged 18-94 years) with clinically suspected choledocholithiasis underwent unenhanced helical CT imm...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.203.3.9169700

    authors: Neitlich JD,Topazian M,Smith RC,Gupta A,Burrell MI,Rosenfield AT

    更新日期:1997-06-01 00:00:00

  • Male breast carcinoma and gynecomastia: comparison of mammography with sonography.

    abstract::Both ultrasonography and x-ray mammography were performed on a male patient who had breast carcinoma. While the x-ray mammographic features were highly suggestive of malignancy, the sonographic findings were subtle. Because of the technical difficulties associated with x-ray mammography of the male breast, ultrasound ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.2.6622700

    authors: Jackson VP,Gilmor RL

    更新日期:1983-11-01 00:00:00

  • Unknown primary tumors: detection with dual-modality PET/CT--initial experience.

    abstract:PURPOSE:To retrospectively evaluate fused positron emission tomography (PET)/computed tomography (CT) in depicting the primary lesion in cancer of an unknown primary tumor, compared with PET, CT, and PET and CT side-by-side evaluation. MATERIALS AND METHODS:Institutional review board approval and informed consent were...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2341031554

    authors: Gutzeit A,Antoch G,Kühl H,Egelhof T,Fischer M,Hauth E,Goehde S,Bockisch A,Debatin J,Freudenberg L

    更新日期:2005-01-01 00:00:00

  • Holoprosencephaly in children: diffusion tensor MR imaging of white matter tracts of the brainstem--initial experience.

    abstract:PURPOSE:To evaluate the dimensions of specific white matter tracts in the brainstems (region of brain thought to be least affected) of children with holoprosencephaly by using diffusion tensor magnetic resonance (MR) imaging and to correlate these abnormalities with forebrain malformation severity and neurologic defici...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2233011197

    authors: Albayram S,Melhem ER,Mori S,Zinreich SJ,Barkovich AJ,Kinsman SL

    更新日期:2002-06-01 00:00:00

  • Periampullary tumors: high-spatial-resolution MR imaging and histopathologic findings in ampullary region specimens.

    abstract:PURPOSE:To prospectively determine the magnetic resonance (MR) signal intensity characteristics of structures of the ampullary region and to assess the potential use of MR imaging in evaluation of the extent of periampullary tumors in resected specimens. MATERIALS AND METHODS:Twenty-five specimens from the ampullary r...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2313030797

    authors: Sugita R,Furuta A,Ito K,Fujita N,Ichinohasama R,Takahashi S

    更新日期:2004-06-01 00:00:00

  • Telangiectatic focal nodular hyperplasia: US, CT, and MR imaging findings with histopathologic correlation in 13 cases.

    abstract:PURPOSE:To review the ultrasonographic (US), computed tomographic (CT), and magnetic resonance (MR) imaging findings in 13 patients with telangiectatic focal nodular hyperplasia (FNH) and to compare imaging features with histopathologic results from resected specimens. MATERIALS AND METHODS:US, helical multiphasic CT,...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2282020040

    authors: Attal P,Vilgrain V,Brancatelli G,Paradis V,Terris B,Belghiti J,Taouli B,Menu Y

    更新日期:2003-08-01 00:00:00

  • Clinical and radiographic manifestations of aortoesophageal fistulas.

    abstract::Aneurysms of the thoracic aorta simulated primary esophageal disease both clinically and radiographically in 5 patients. Four had an aortoesophageal fistula at the time of presentation; endoscopic biopsy of a presumed esophageal tumor precipitated hematemesis in the fifth patient. In retrospect, the fistulas were demo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.141.3.7302210

    authors: Baron RL,Koehler RE,Gutierrez FR,Forrest JV,Weyman PJ

    更新日期:1981-12-01 00:00:00

  • Ghost infantile vertebrae and hemipelves within adult skeleton from thorotrast administration in childhood.

    abstract::In 2 adults who had received thorotrast intravenously at ages 2 and 3 years, respectively, radiopaque outlines of their infantile vertebrae were seen in the adult vertebrae. Similar "ghosts" of the hemipelves were present in the pelvis of 1 patient. Autopsy findings and autoradiographs in 1 patient strongly suggest th...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/129.3.657

    authors: Teplick JG,Head GL,Kricun ME,Haskin ME

    更新日期:1978-12-01 00:00:00

  • Clinical Outcomes of Radiofrequency Ablation for Early Hypovascular HCC: A Multicenter Retrospective Study.

    abstract::Purpose To retrospectively evaluate the clinical outcomes of radiofrequency ablation (RFA) for early hypovascular hepatocellular carcinomas (HCCs) and to compare them with those of typical hypervascular HCCs. Materials and Methods This retrospective multicenter study received institutional review board approval, with ...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiol.2017162452

    authors: Lee DH,Lee JM,Kang TW,Rhim H,Kim SY,Shin YM,Seo JW,Choi MH,Lee KB

    更新日期:2018-01-01 00:00:00

  • Computer-aided detection in digital mammography: comparison of craniocaudal, mediolateral oblique, and mediolateral views.

    abstract:PURPOSE:To retrospectively compare the sensitivity of a computer-aided detection (CAD) system for depicting breast cancer in three digital mammographic views. MATERIALS AND METHODS:This study was conducted with institutional review board approval; informed consent was waived. A commercially available CAD system was ap...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2413051145

    authors: Kim SJ,Moon WK,Cho N,Cha JH,Kim SM,Im JG

    更新日期:2006-12-01 00:00:00

  • Percutaneous catheter drainage of deep neck infections guided by CT.

    abstract::We report success with CT guided percutaneous catheter drainage of deep neck abscesses. The cost efficacy and decreased morbidity of percutaneous catheter drainage has been proved in abdominal and retroperitoneal abscess management, and CT for diagnosis of deep neck infections is well established. The logical applicat...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.152.1.6729120

    authors: Cole DR,Bankoff M,Carter BL

    更新日期:1984-07-01 00:00:00

  • A modular computer system for the nuclear medicine/ultrasound laboratory.

    abstract::Computer-controlled graphic displays are a necessity in many nuclear medicine studies. The authors propose using a set-up consisting of three modules: (a) a display system based on television technology; (b) an instrument interface employing list mode and having a low information loss rate; and (c) flexible modular so...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/124.3.759

    authors: Noz ME,Schimpf JH,Maguire GQ Jr

    更新日期:1977-09-01 00:00:00

  • Breast microcalcifications after lumpectomy and radiation therapy.

    abstract::Ten of 152 (7%) consecutive breast cancer patients who underwent excisional biopsy and radiation therapy developed suspect microcalcifications at the biopsy site. All ten patients underwent reexcision. Seventeen other patients developed scattered, coarse, benign macrocalcifications that have remained stable as determi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.170.3.2492670

    authors: Rebner M,Pennes DR,Adler DD,Helvie MA,Lichter AS

    更新日期:1989-03-01 00:00:00

  • Diffuse panbronchiolitis: follow-up CT examination.

    abstract:PURPOSE:The authors reviewed serial computed tomographic (CT) scans obtained in 19 patients with diffuse panbronchiolitis (DPB) to evaluate changes in disease pattern over time. MATERIALS AND METHODS:Nineteen patients with DPB were entered into the study. After initial CT examination, 12 patients were randomly assigne...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1148/radiology.189.2.8210390

    authors: Akira M,Higashihara T,Sakatani M,Hara H

    更新日期:1993-11-01 00:00:00

  • Splenic vein thrombosis after splenectomy: frequency and role of imaging.

    abstract:PURPOSE:To assess the frequency of splenic vein thrombosis (SVT) after splenectomy and its consequences on patient treatment. MATERIALS AND METHODS:A group of 183 consecutive patients who underwent splenectomy were evaluated. Of these patients, 119 underwent postoperative ultrasound (US) or computed tomography. RESUL...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.190.1.8259430

    authors: Petit P,Bret PM,Atri M,Hreno A,Casola G,Gianfelice D

    更新日期:1994-01-01 00:00:00

  • Endoscopic ultrasonic evaluation of the prostate using a transrectal probe: prospective evaluation and acoustic characterization.

    abstract::Transrectal sonography of the normal prostate demonstrates a gland that has low-level homogeneous echoes. Benign and malignant prostatic disease causes disruption of this normal texture. A prospective study was performed to determine the ability of ultrasound to detect focal defects accurately. The specific histologic...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.1.6193560

    authors: Rifkin MD,Kurtz AB,Choi HY,Goldberg BB

    更新日期:1983-10-01 00:00:00

  • Cardiac CT angiography for the diagnosis of mitral valve prolapse: comparison with echocardiography1.

    abstract:PURPOSE:To evaluate the diagnostic performance of coronary computed tomographic (CT) angiography for the diagnosis of mitral valve prolapse (MVP). MATERIALS AND METHODS:The retrospective case-controlled multicenter study protocol was approved by the institutional review boards. The U.S. part of the study was HIPAA com...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiol.2541090393

    authors: Feuchtner GM,Alkadhi H,Karlo C,Sarwar A,Meier A,Dichtl W,Leschka S,Blankstein R,Gruenenfelder J,Stolzmann P,Cury RC

    更新日期:2010-02-01 00:00:00

  • Transcatheter fiberoptic laser coagulation of blood vessels.

    abstract::In ten rabbit ears the central auricular artery was percutaneously catheterized and subjected to doses of laser energy transmitted through a flexible optical fiber within the artery. Arterial occlusion was not produced in the initial three ears using energy levels less than 600 mW. Higher levels of laser energy, in th...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.142.3.7199750

    authors: O'Reilly GV,Colucci VM,Astorian DG,Schoene WC,Clarke RH,Hammerschlag SB

    更新日期:1982-03-01 00:00:00

  • PET evaluation of soft-tissue masses with fluorine-18 fluoro-2-deoxy-D-glucose.

    abstract::Positron emission tomography (PET) with fluorine-18 fluoro-2-deoxy-D-glucose (FDG) was performed in 19 patients referred for clinical evaluation of soft-tissue masses. These patients had 20 different lesions and had been evaluated previously with computed tomography (CT) and/or magnetic resonance (MR) imaging. The dia...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.182.1.1727280

    authors: Griffeth LK,Dehdashti F,McGuire AH,McGuire DJ,Perry DJ,Moerlein SM,Siegel BA

    更新日期:1992-01-01 00:00:00

  • Superior labral anterior posterior (SLAP) lesions of the glenoid labrum: reliability and accuracy of MR arthrography for diagnosis.

    abstract:PURPOSE:To determine the reliability and accuracy of magnetic resonance (MR) arthrography for the diagnosis of superior labral anterior posterior (SLAP) tears. MATERIALS AND METHODS:The MR arthrograms in 80 patients who underwent arthroscopy and MR arthrography during a 54-month period were retrospectively reviewed. M...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.218.1.r01ja44127

    authors: Jee WH,McCauley TR,Katz LD,Matheny JM,Ruwe PA,Daigneault JP

    更新日期:2001-01-01 00:00:00

  • Meniscal lesions of the knee joint: CT diagnosis.

    abstract::Computed tomography (CT) resulted in a diagnostic accuracy of 89.2% and 96.1% for medial and lateral meniscal lesions, respectively, in 109 patients who underwent surgery after a direct CT study of the knee joint for a clinically suspected meniscal lesion. The meniscal lesions were the only pathologic condition found ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.157.1.3839930

    authors: Passariello R,Trecco F,de Paulis F,Masciocchi C,Bonanni G,Zobel BB

    更新日期:1985-10-01 00:00:00

  • Ileal lymphatic metastases from cecal carcinoma.

    abstract::Involvement of the terminal ileum in cases of cecal carcinoma usually results from direct extension through the cecal wall and ileocecal valve. Extensive lymphatic metastasis from cecal carcinoma can result in deranged lymphatic flow and apparently cause metastatic involvement of the ileum and its mesentery in the abs...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.135.1.7360980

    authors: Moffat RE,Gourley WK

    更新日期:1980-04-01 00:00:00

  • Evaluation of heavily calcified vessels with coronary CT angiography: comparison of iterative and filtered back projection image reconstruction.

    abstract:PURPOSE:To prospectively compare traditional filtered back projection (FBP) and iterative image reconstruction for the evaluation of heavily calcified arteries with coronary computed tomography (CT) angiography. MATERIALS AND METHODS:The study had institutional review board approval and was HIPAA compliant. Written in...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11103574

    authors: Renker M,Nance JW Jr,Schoepf UJ,O'Brien TX,Zwerner PL,Meyer M,Kerl JM,Bauer RW,Fink C,Vogl TJ,Henzler T

    更新日期:2011-08-01 00:00:00

  • Case 241: Hemiparkinsonism- Hemiatrophy-SPECT with 99mTc TRODAT-1 and Muscle MR Imaging Abnormalities.

    abstract::History A 43-year-old right-handed man presented with a history of progressive mild left-sided weakness and slowness of movements. Symptoms began 4 years earlier, and the patient noticed a progressive decline in his daily routine due to gait difficulties in the past year. There was no history of head trauma, surgery, ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2017151717

    authors: Vale TC,de Lima Pinto FC,Pedroso JL,Alves Dos Reis M,Batista IR,Affonseca Bressan R,Magalhães Rivero RL,Mendonça RA,Barsottini OG

    更新日期:2017-05-01 00:00:00

  • A new photon scattering method for bone mineral density measurements.

    abstract::A new technique for the determination of bone mineral density, based on the detection of both coherently and Compton scattered photons in a narrow beam geometry, is described. Initial results show that this method delivers an accuracy of less than 2% when varying quantities of materials surround the measuring site. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/120.3.723

    authors: Puumalainen P,Uimarihuhta A,Olkkonen H

    更新日期:1976-09-01 00:00:00

  • Aortic dissection: magnetic resonance imaging.

    abstract::Fifteen patients with suspected or known aortic dissection were imaged with magnetic resonance (MR). Thirteen of these patients were eventually shown to have dissection. In most instances the diagnosis was established by aortography and/or computed tomography (CT) prior to the MR study. Surgical proof (6/13) and/or ao...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.155.2.3983390

    authors: Amparo EG,Higgins CB,Hricak H,Sollitto R

    更新日期:1985-05-01 00:00:00

  • Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT.

    abstract:PURPOSE:To retrospectively compare sensitivity and specificity of magnetic resonance (MR) imaging, three-dimensional (3D) MR spectroscopy, combined MR imaging and 3D MR spectroscopy, and carbon 11 (11C)-choline positron emission tomography (PET)/computed tomography (CT) for intraprostatic tumor sextant localization, wi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2443061063

    authors: Testa C,Schiavina R,Lodi R,Salizzoni E,Corti B,Farsad M,Kurhanewicz J,Manferrari F,Brunocilla E,Tonon C,Monetti N,Castellucci P,Fanti S,Coe M,Grigioni WF,Martorana G,Canini R,Barbiroli B

    更新日期:2007-09-01 00:00:00

  • Evaluation of focal defects on technetium-99m sulfur colloid scans with new hepatobiliary agents.

    abstract::In 3,600 patients evaluated with technetium-99m sulfur colloid for metastatic liver disease, 40 had equivocal scans due to a solitary defect in the interior margin of the right lobe. In these patients, the authors differentiated the gallbladder fossa from a metastatic focus using one of two new hepatobiliary agents: t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.136.2.7403530

    authors: Rao BK,Pastakia B,Lieberman LM

    更新日期:1980-08-01 00:00:00

  • Nuclear imaging, tomographic nuclear imaging, and gray scale ultrasound in the evaluation of the porta hepatis.

    abstract::Twenty-six patients with an eqivocal portal defect on conventional nuclear images were evaluated with a multiplane tomographic nuclear scanner and gray scale ultrasound. In most cases the correct determination (normal or abnormal) for an area of decreased uptake could be made from the multiplane tomographic scans. Whe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/122.3.773

    authors: Sample WF,Gray RK,Poe ND,Graham LS,Bennett LR

    更新日期:1977-03-01 00:00:00